ZFIN ID: ZDB-PUB-110523-1
Zebrafish lipid metabolism: from mediating early patterning to the metabolism of dietary fat and cholesterol
Anderson, J.L., Carten, J.D., and Farber, S.A.
Date: 2011
Source: Methods in cell biology   101: 111-141 (Chapter)
Registered Authors: Anderson, Jennifer, Carten, Juliana, Farber, Steven
Keywords: cholesterol, dietary fat, dyslipidemia, early patterning, lipid metabolism, lipid signaling
MeSH Terms:
  • Animals
  • Cholesterol/metabolism*
  • Dietary Fats/metabolism*
  • Humans
  • Lipid Metabolism/physiology*
  • Zebrafish/metabolism*
PubMed: 21550441 Full text @ Meth. Cell. Biol.
Lipids serve essential functions in cells as signaling molecules, membrane components, and sources of energy. Defects in lipid metabolism are implicated in a number of pandemic human diseases, including diabetes, obesity, and hypercholesterolemia. Many aspects of how fatty acids and cholesterol are absorbed and processed by intestinal cells remain unclear and present a hurdle to developing approaches for disease prevention and treatment. Numerous studies have shown that the zebrafish is an excellent model for vertebrate lipid metabolism. In this chapter, we review studies that employ zebrafish to better understand lipid signaling and metabolism.