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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-960805-172
Farber, Steven
Email: farber@ciwemb.edu
URL: http://www.ciwemb.edu/labs/farber/index.php
Affiliation: Farber Lab
Address: Carnegie Institution Department of Embryology 3520 San Martin Drive Baltimore, MD 21218 USA
Country: United States
Phone: (410) 246-3072
Fax: (410) 243-6311
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Thierer, J.H., Ekker, S.C., Farber, S.A. (2019) The LipoGlo reporter system for sensitive and specific monitoring of atherogenic lipoproteins. Nature communications. 10:3426
Otis, J.P., Shen, M.C., Caldwell, B.A., Reyes Gaido, O.E., Farber, S.A. (2019) Dietary cholesterol and apolipoprotein A-I are trafficked in endosomes and lysosomes in the live zebrafish intestine. American journal of physiology. Gastrointestinal and liver physiology. 316(3):G350-G365
Sæle, Ø., Rød, K.E.L., Quinlivan, V.H., Li, S., Farber, S.A. (2018) A novel system to quantify intestinal lipid digestion and transport. Biochimica et biophysica acta. 1863(9):948-957
Anderson, J.L., Mulligan, T.S., Shen, M.C., Wang, H., Scahill, C.M., Tan, F.J., Du, S.J., Busch-Nentwich, E.M., Farber, S.A. (2017) mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense-mediated decay. PLoS Genetics. 13:e1007105
Quinlivan, V.H., Farber, S.A. (2017) Lipid Uptake, Metabolism, and Transport in the Larval Zebrafish. Frontiers in endocrinology. 8:319
O'Hare, E.A., Yang, R., Yerges-Armstrong, L., Sreenivasan, U., McFarland, R., Leitch, C.C., Wilson, M.H., Narina, S., Gorden, A., Ryan, K., Shuldiner, A.R., Farber, S.A., Wood, G.C., Still, C.D., Gerhard, G.S., Robishaw, J.D., Sztalryd, C., Zaghloul, N.A. (2017) TM6SF2 rs58542926 impacts lipid processing in liver and small intestine. Hepatology (Baltimore, Md.). 65(5):1526-1542
Quinlivan, V.H., Wilson, M.H., Ruzicka, J., Farber, S.A. (2017) An HPLC-CAD/Fluorescence Lipidomics Platform Using Fluorescent Fatty Acids as Metabolic Tracers. Journal of Lipid Research. 58(5):1008-1020
Otis, J.P., Shen, M.C., Quinlivan, V., Anderson, J.L., Farber, S.A. (2017) Intestinal epithelial cell Caveolin 1 regulates fatty acid and lipoprotein cholesterol plasma levels. Disease models & mechanisms. 10(3):283-295
Shuda, J.R., Butler, V.G., Vary, R., Farber, S.A. (2016) Project BioEYES: Accessible Student-Driven Science for K-12 Students and Teachers. PLoS Biology. 14:e2000520
Zeituni, E.M., Wilson, M.H., Zheng, X., Iglesias, P.A., Sepanski, M., Siddiqi, M.A., Anderson, J.L., Zheng, Y., Farber, S.A. (2016) Endoplasmic reticulum lipid flux influences enterocyte nuclear morphology and lipid-dependent transcriptional responses. The Journal of biological chemistry. 291(45):23804-23816
Otis, J.P., Farber, S.A. (2016) High-fat Feeding Paradigm for Larval Zebrafish: Feeding, Live Imaging, and Quantification of Food Intake. Journal of visualized experiments : JoVE. (116)
Zeituni, E.M., Farber, S.A. (2016) Studying Lipid Metabolism and Transport During Zebrafish Development. Methods in molecular biology (Clifton, N.J.). 1451:237-55
Anderson, J.L., Carten, J.D., Farber, S.A. (2016) Using fluorescent lipids in live zebrafish larvae: From imaging whole animal physiology to subcellular lipid trafficking. Methods in cell biology. 133:165-178
Walters, J.W., Anderson, J.L., Bittman, R., Pack, M., and Farber, S.A. (2015) Retraction: Visualization of Lipid Metabolism in the Zebrafish Intestine Reveals a Relationship between NPC1L1-Mediated Cholesterol Uptake and Dietary Fatty Acid. Chemistry & Biology. 22:1283
Otis, J.P., Zeituni, E.M., Thierer, J.H., Anderson, J.L., Brown, A.C., Boehm, E.D., Cerchione, D.M., Ceasrine, A.M., Avraham-Davidi, I., Tempelhof, H., Yaniv, K., Farber, S.A. (2015) Zebrafish as a model for apolipoprotein biology: Comprehensive expression analysis and a role for ApoA-IV in regulating food intake. Disease models & mechanisms. 8(3):295-309
Miyares, R.L., de Rezende, V.B., Farber, S.A. (2014) Zebrafish yolk lipid processing: a tractable tool for the study of vertebrate lipid transport and metabolism. Disease models & mechanisms. 7(7):915-27
Miyares, R.L., Stein, C., Renisch, B., Anderson, J.L., Hammerschmidt, M., and Farber, S.A. (2013) Long-Chain Acyl-CoA Synthetase 4A Regulates Smad Activity and Dorsoventral Patterning in the Zebrafish Embryo. Developmental Cell. 27(6):635-647
Sadler, K.C., Rawls, J.F., and Farber, S.A. (2013) Getting the inside tract: new frontiers in zebrafish digestive system biology. Zebrafish. 10(2):129-131
Otis, J.P., and Farber, S.A. (2013) Imaging vertebrate digestive function and lipid metabolism in vivo.. Drug Discovery Today: Disease Models. 10(1):e11-e16
Semova, I., Carten, J.D., Stombaugh, J., Mackey, L.C., Knight, R., Farber, S.A., and Rawls, J.F. (2012) Microbiota regulate intestinal absorption and metabolism of Fatty acids in the zebrafish. Cell Host & Microbe. 12(3):277-288
Walters, J.W., Anderson, J.L., Bittman, R., Pack, M., and Farber, S.A. (2012) RETRACTED: Visualization of lipid metabolism in the zebrafish intestine reveals a relationship between NPC1L1-mediated cholesterol uptake and dietary fatty acid. Chemistry & Biology. 19:913-925
Avraham-Davidi, I., Ely, Y., Pham, V.N., Castranova, D., Grunspan, M., Malkinson, G., Gibbs-Bar, L., Mayseless, O., Allmog, G., Lo, B., Warren, C.M., Chen, T.T., Ungos, J., Kidd, K., Shaw, K., Rogachev, I., Wan, W., Murphy, P.M., Farber, S.A., Carmel, L., Shelness, G.S., Iruela-Arispe, M.L., Weinstein, B.M., and Yaniv, K. (2012) ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1. Nature medicine. 18(6):967-973
Delous, M., Yin, C., Shin, D., Ninov, N., Debrito Carten, J., Pan, L., Ma, T.P., Farber, S.A., Moens, C.B., and Stainier, D.Y. (2012) sox9b Is a Key Regulator of Pancreaticobiliary Ductal System Development. PLoS Genetics. 8(6):e1002754
Carten, J.D., Bradford, M.K., and Farber, S. (2011) Visualizing digestive organ morphology and function using differential fatty acid metabolism in live zebrafish. Developmental Biology. 360(2):276-85
Anderson, J.L., Carten, J.D., and Farber, S.A. (2011) Zebrafish lipid metabolism: from mediating early patterning to the metabolism of dietary fat and cholesterol. Methods in cell biology. 101:111-141
Anderson, J.L., Macurak, M.L., Halpern, M.E., and Farber, S.A. (2010) A Versatile Aquatics Facility Inventory System with Real-Time Barcode Scan Entry. Zebrafish. 7(3):281-287
Clifton, J.D., Lucumi, E., Myers, M.C., Napper, A., Hama, K., Farber, S.A., Smith, A.B. 3rd, Huryn, D.M., Diamond, S.L., and Pack, M. (2010) Identification of novel inhibitors of dietary lipid absorption using zebrafish. PLoS One. 5(8):e12386
Mulligan, T., Blaser, H., Raz, E., and Farber, S.A. (2010) Prenylation-deficient G protein gamma subunits disrupt GPCR signaling in the zebrafish. Cellular Signalling. 22(2):221-233
Carten, J.D., and Farber, S.A. (2009) A new model system swims into focus: using the zebrafish to visualize intestinal metabolism in vivo. Clinical lipidology. 4(4):501
Hama, K., Provost, E., Baranowski, T.C., Rubinstein, A.L., Anderson, J.L., Leach, S.D., and Farber, S.A. (2009) In vivo imaging of zebrafish digestive organ function using multiple quenched fluorescent reporters. American journal of physiology. Gastrointestinal and liver physiology. 296(2):G445-G453
Barresi, M.J., Farber, S.A., Hutson, L.D., Hyde, D.R., Liang, J.O., and Morris, J.K. (2008) Zebrafish in the Classroom. Zebrafish. 5(3):205-208
Ouyang, M., Garnett, A.T., Han, T.M., Hama, K., Lee, A., Deng, Y., Lee, N., Liu, H.Y., Amacher, S.L., Farber, S.A., and Ho, S.Y. (2008) A web based resource characterizing the zebrafish developmental profile of over 16,000 transcripts. Gene expression patterns : GEP. 8(3):171-180
Robu, M.E., Larson, J.D., Nasevicius, A., Beiraghi, S., Brenner, C., Farber, S.A., and Ekker, S.C. (2007) p53 activation by knockdown technologies. PLoS Genetics. 3(5):e78
Pickart, M.A., Klee, E.W., Nielsen, A.L., Sivasubbu, S., Mendenhall, E.M., Bill B.R., Chen, E., Eckfeldt, C.E., Knowlton, M., Robu, M.E., Larson, J.D., Deng, Y., Schimmenti, L.A., Ellis, L.B., Verfaillie, C.M., Hammerschmidt, M., Farber, S.A., and Ekker, S.C. (2006) Genome-wide reverse genetics framework to identify novel functions of the vertebrate secretome. PLoS One. 1(1):e104
Ho, S.Y., Lorent, K., Pack, M., and Farber, S.A. (2006) Zebrafish fat-free is required for intestinal lipid absorption and Golgi apparatus structure. Cell Metabolism. 3(4):289-300
Ghiselli, G., and Farber, S.A. (2005) D-glucuronyl C5-epimerase acts in dorso-ventral axis formation in zebrafish. BMC Developmental Biology. 5:19
Duffy, K.T., McAleer, M.F., Davidson, W.R., Kari, L., Kari, C., Liu, C.G., Farber, S.A., Cheng, K.C., Mest, J.R., Wickstrom, E., Dicker, A.P., and Rodeck, U. (2005) Coordinate control of cell cycle regulatory genes in zebrafish development tested by cyclin D1 knockdown with morpholino phosphorodiamidates and hydroxyprolyl-phosphono peptide nucleic acids. Nucleic acids research. 33(15):4914-4921
McAleer, M.F., Davidson, C., Davidson, W.R., Yentzer, B., Farber, S.A., Rodeck, U., and Dicker, A.P. (2005) Novel use of zebrafish as a vertebrate model to screen radiation protectors and sensitizers. International journal of radiation oncology, biology, physics. 61(1):10-13
Mulligan, T.S., and Farber, S.A. (2005) A "Block and Rescue" Pharmacogenetic Approach to Dissecting a Biochemical Pathway Controlling Germ Cell Migration. Zebrafish. 1(4):343-347
Wickstrom, E., Choob, M., Urtishak, K.A., Tian, X., Sternheim, N., Talbot, S., Archdeacon, J., Efimov, V.A., and Farber, S.A. (2004) Sequence specificity of alternating hydroyprolyl/phosphono peptide nucleic acids against zebrafish embryo mRNAs. Journal of drug targeting. 12(6):363-372
Guo, Y., Cheong, N., Zhang, Z., De Rose, R., Deng, Y., Farber, S.A., Fernandes-Alnemri, T., Alnemri, E.S. (2004) Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death. The Journal of biological chemistry. 279(23):24813-24825
Smart, E.J., De Rose, R.A., and Farber, S.A. (2004) Annexin 2-caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport. Proceedings of the National Academy of Sciences of the United States of America. 101(10):3450-3455
Thorpe, J.L., Doitsidou, M., Ho, S.-Y., Raz, E., and Farber, S.A. (2004) Germ Cell Migration in Zebrafish Is Dependent on HMGCoA Reductase Activity and Prenylation. Developmental Cell. 6:5-302
Ho, S.Y., Thorpe, J.L., Deng, Y., Santana, E., DeRose, R.A., and Farber, S.A. (2004) Lipid metabolism in zebrafish. The Zebrafish: Cellular and Developmental Biology,2nd Ed. Methods Cell Biol.. 76:87-108
Urtishak, K.A., Choob, M., Tian, X., Sternheim, N., Talbot, W.S., Wickstrom, E., and Farber, S.A. (2003) Targeted gene knockdown in zebrafish using negatively charged peptide nucleic acid mimics. Developmental dynamics : an official publication of the American Association of Anatomists. 228(3):405-413
Farber, S.A., De Rose, R.A., Olson, E.S., and Halpern, M.E. (2003) The zebrafish annexin gene family. Genome research. 13(6):1082-1096
Ho, S.Y., Pack, M., and Farber, S.A. (2003) Analysis of small molecule metabolism in zebrafish. Methods in enzymology. 364:408-426
Farber, S.A., Pack, M., Ho, S.Y., Johnson, I.D., Wagner, D.S., Dosch, R., Mullins, M.C., Hendrickson, H.S., Hendrickson, E.K., and Halpern, M.E. (2001) Genetic analysis of digestive physiology using fluorescent phospholipid reporters. Science (New York, N.Y.). 292(5520):1385-1388
Ho, S.Y., Pack, M., and Farber, S.A. (2001) Real-time imaging of lipid processing in wild type and mutant zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15(5):A1102
Hendrickson, H.S., Hendrickson, E.K., Johnson, I.D., and Farber, S.A. (1999) Intramolecularly quenched BODIPY-labeled phospholipid analogs in phospholipase A(2) and platelet-activating factor acetylhydrolase assays and in vivo fluorescence imaging. Analytical biochemistry. 276(1):27-35
Farber, S.A., Olson, E.S., Clark, J.D., and Halpern, M.E. (1999) Characterization of Ca2+-dependent phospholipase A2 activity during zebrafish embryogenesis. The Journal of biological chemistry. 274(27):19338-19346

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