|ZFIN ID: ZDB-PUB-110408-3|
Tissue regeneration after injury in adult zebrafish: The regenerative potential of the caudal fin
Shao, J., Chen, D., Ye, Q., Cui, J., Li, Y., and Li, L..
|Source:||Developmental dynamics : an official publication of the American Association of Anatomists 240(5): 1271-1277 (Journal)|
|Registered Authors:||Li, Lei, Li, Yuhao|
|Keywords:||zebrafish; regeneration potential; caudal fin, marker gene expression|
|PubMed:||21412938 Full text @ Dev. Dyn.|
Shao, J., Chen, D., Ye, Q., Cui, J., Li, Y., and Li, L.. (2011) Tissue regeneration after injury in adult zebrafish: The regenerative potential of the caudal fin. Developmental dynamics : an official publication of the American Association of Anatomists. 240(5):1271-1277.
ABSTRACTThe zebrafish has the potential to regenerate many of its tissues. In this study, we examined caudal fin regeneration in zebrafish that received repeated injuries (fin amputation) at different ages. In zebrafish that received repeated injuries, the potential for caudal fin regeneration, such as tissue growth and the expression of regeneration marker genes (msxb, fgf20a, bmp2b), did not decline in comparison to zebrafish that received only one amputation surgery. The process of initial fin regeneration (e.g., tissue outgrowth and the expression of regeneration marker genes at 7 days post-amputation) did not seem to correlate with age. However, slight differences in fin outgrowth were observed between young and old animals when examined in the late regeneration stages (e.g., 20 and 30 days post-amputation). Together, the data suggest that zebrafish has unlimited regenerative potential in the injured caudal fin. Developmental Dynamics, 2011.
- Genes / Markers (3)