PUBLICATION
Enhanced hyperplasia in muscles of transgenic zebrafish expressing Follistatin1
- Authors
- Li, X., Nie, F., Yin, Z., and He, J.
- ID
- ZDB-PUB-110221-9
- Date
- 2011
- Source
- Science China. Life sciences 54(2): 159-165 (Journal)
- Registered Authors
- He, Jiangyan, Li, Xi, Yin, Zhan
- Keywords
- Follistatin1, myostatin, muscle growth, transgenic, zebrafish
- MeSH Terms
-
- Myosin Light Chains/genetics
- Myosin Light Chains/metabolism
- Animals, Genetically Modified/anatomy & histology*
- Animals, Genetically Modified/metabolism*
- Hyperplasia
- Zebrafish*/anatomy & histology
- Zebrafish*/genetics
- Zebrafish*/metabolism
- Muscle, Skeletal/cytology
- Muscle, Skeletal/pathology*
- Muscle, Skeletal/physiology*
- Animals
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- Follistatin/genetics
- Follistatin/metabolism*
- In Situ Hybridization
- Cardiac Myosins/genetics
- Cardiac Myosins/metabolism
- Mice
- PubMed
- 21318486 Full text @ Sci. China Ser. C-Life Sci.
Citation
Li, X., Nie, F., Yin, Z., and He, J. (2011) Enhanced hyperplasia in muscles of transgenic zebrafish expressing Follistatin1. Science China. Life sciences. 54(2):159-165.
Abstract
Myostatin is a member of the transforming growth factor-β (TGF-β) super-family and functions as a negative regulator of muscle growth. Binding of the specific receptor, Activin receptor IIB (Act RIIB), with myostatin or other related TGF-β members, could be inhibited by the activin-binding protein follistatin (Fst) in mammals. Overexpressing Fst in mouse skeletal muscle leads to muscle hypertrophy and hyperplasia. To determine if Fst has similar roles in fish, we generated transgenic zebrafish expressing high levels of zebrafish Fst1 using the promoter of the zebrafish skeletal muscle-specific gene, myosin, light polypeptide 2, skeletal muscle (Mylz2). Independent transgenic zebrafish lines exhibited elevated expression levels of myogenic regulatory genes MyoD and Pax7 in muscle cells. Adult Fst1 overexpressing transgenic zebrafish exhibited a slight body weight increase. The high level of Fst1 expression dramatically increased myofiber numbers in skeletal muscle, without significantly changing the fiber size. Our findings suggest that Fst1 overexpression can promote zebrafish muscle growth by enhancing myofiber hyperplasia.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping