ZFIN ID: ZDB-PUB-110119-24
Characterization of the laminin gene family and evolution in zebrafish
Sztal, T., Berger, S., Currie, P.D., and Hall, T.E.
Date: 2011
Source: Developmental dynamics : an official publication of the American Association of Anatomists   240(2): 422-431 (Journal)
Registered Authors: Berger, Silke, Currie, Peter D., Hall, Thomas, Sztal, Tamar Esther
Keywords: laminin, zebrafish, muscle, in situ hybridization
MeSH Terms:
  • Animals
  • Biological Evolution*
  • Gene Expression Regulation, Developmental*
  • Humans
  • In Situ Hybridization
  • Laminin/classification
  • Laminin/genetics*
  • Laminin/metabolism
  • Multigene Family*
  • Phylogeny
  • Protein Isoforms/classification
  • Protein Isoforms/genetics*
  • Protein Isoforms/metabolism
  • Synteny
  • Tissue Distribution
  • Zebrafish/anatomy & histology
  • Zebrafish/embryology*
  • Zebrafish/genetics*
PubMed: 21246659 Full text @ Dev. Dyn.
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ABSTRACT
Laminins are essential components of all basement membranes and are fundamental to tissue development and homeostasis. Humans possess at least 16 different heterotrimeric laminin complexes formed through different combinations of alpha, beta, and gamma chains. Individual chains appear to exhibit unique expression patterns, leading to the notion that overlap between expression domains governs the constitution of complexes found within particular tissues. However, the spatial and temporal expression of laminin genes has not been comprehensively analyzed in any vertebrate model to date. Here, we describe the tissue-specific expression patterns of all laminin genes in the zebrafish, throughout embryonic development and into the "post-juvenile" period, which is representative of the adult body form. In addition, we present phylogenetic and microsynteny analyses, which demonstrate that the majority of our zebrafish sequences are orthologous to human laminin genes. Together, these data represent a fundamental resource for the study of vertebrate laminins.
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