|ZFIN ID: ZDB-PUB-101201-33|
Chapter 11 - Monitoring sleep and arousal in zebrafish
Rihel, J., Prober, D.A., and Schier, A.F.
|Source:||Methods in cell biology 100: 281-294 (Chapter)|
|Registered Authors:||Prober, David, Rihel, Jason, Schier, Alexander|
|PubMed:||21111222 Full text @ Meth. Cell. Biol.|
Rihel, J., Prober, D.A., and Schier, A.F. (2010) Chapter 11 - Monitoring sleep and arousal in zebrafish. Methods in cell biology. 100:281-294.
ABSTRACTZebrafish has emerged in the past 5 years as a model for the study of sleep and wake behaviors. Experimental evidence has shown that periods of behavioral quiescence in zebrafish larvae and adults are sleep-like states, as these rest bouts are regulated by the circadian cycle, are associated with decreases in arousal, and are increased following rest deprivation. Furthermore, zebrafish share with mammals a hypocretin/orexin system that promotes wakefulness, and drugs that alter mammalian sleep have similar effects on zebrafish rest. In this chapter, we review the zebrafish sleep literature and describe a long-term, high-throughput monitoring system for observing sleep and wake behaviors in larval zebrafish.
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