PUBLICATION
Chapter 11 - Monitoring sleep and arousal in zebrafish
- Authors
- Rihel, J., Prober, D.A., and Schier, A.F.
- ID
- ZDB-PUB-101201-33
- Date
- 2010
- Source
- Methods in cell biology 100: 281-294 (Chapter)
- Registered Authors
- Prober, David, Rihel, Jason, Schier, Alexander
- Keywords
- none
- MeSH Terms
-
- Arousal*
- Sleep*
- Zebrafish/embryology
- Zebrafish/genetics
- Zebrafish/physiology*
- Animals
- PubMed
- 21111222 Full text @ Meth. Cell. Biol.
Citation
Rihel, J., Prober, D.A., and Schier, A.F. (2010) Chapter 11 - Monitoring sleep and arousal in zebrafish. Methods in cell biology. 100:281-294.
Abstract
Zebrafish has emerged in the past 5 years as a model for the study of sleep and wake behaviors. Experimental evidence has shown that periods of behavioral quiescence in zebrafish larvae and adults are sleep-like states, as these rest bouts are regulated by the circadian cycle, are associated with decreases in arousal, and are increased following rest deprivation. Furthermore, zebrafish share with mammals a hypocretin/orexin system that promotes wakefulness, and drugs that alter mammalian sleep have similar effects on zebrafish rest. In this chapter, we review the zebrafish sleep literature and describe a long-term, high-throughput monitoring system for observing sleep and wake behaviors in larval zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping