ZFIN ID: ZDB-PUB-101201-33
Chapter 11 - Monitoring sleep and arousal in zebrafish
Rihel, J., Prober, D.A., and Schier, A.F.
Date: 2010
Source: Methods in cell biology   100: 281-294 (Chapter)
Registered Authors: Prober, David, Rihel, Jason, Schier, Alexander
Keywords: none
MeSH Terms:
  • Animals
  • Arousal*
  • Sleep*
  • Zebrafish/embryology
  • Zebrafish/genetics
  • Zebrafish/physiology*
PubMed: 21111222 Full text @ Meth. Cell. Biol.
Zebrafish has emerged in the past 5 years as a model for the study of sleep and wake behaviors. Experimental evidence has shown that periods of behavioral quiescence in zebrafish larvae and adults are sleep-like states, as these rest bouts are regulated by the circadian cycle, are associated with decreases in arousal, and are increased following rest deprivation. Furthermore, zebrafish share with mammals a hypocretin/orexin system that promotes wakefulness, and drugs that alter mammalian sleep have similar effects on zebrafish rest. In this chapter, we review the zebrafish sleep literature and describe a long-term, high-throughput monitoring system for observing sleep and wake behaviors in larval zebrafish.