PUBLICATION

Evolution of genetic networks underlying the emergence of thymopoiesis in vertebrates

Authors
Bajoghli, B., Aghaallaei, N., Hess, I., Rode, I., Netuschil, N., Tay, B.H., Venkatesh, B., Yu, J.K., Kaltenbach, S.L., Holland, N.D., Diekhoff, D., Happe, C., Schorpp, M., and Boehm, T.
ID
ZDB-PUB-101018-34
Date
2009
Source
Cell   138(1): 186-197 (Journal)
Registered Authors
Aghaallaei, Narges, Bajoghli, Baubak, Boehm, Tom, Hess, Isabell, Schorpp, Michael, Venkatesh, Byrappa
Keywords
CELLIMMUNO, EVO_ECOL, DEVBIO
MeSH Terms
  • Animals
  • Biological Evolution*
  • Chemokines/genetics
  • Chemokines/immunology
  • Chordata, Nonvertebrate/genetics
  • Chordata, Nonvertebrate/immunology
  • Fishes/genetics
  • Fishes/immunology
  • Gene Regulatory Networks*
  • Humans
  • Lampreys/genetics
  • Lampreys/immunology
  • Lymphocytes/immunology
  • Molecular Sequence Data
  • Receptors, Chemokine/genetics
  • Receptors, Chemokine/immunology
  • Thymus Gland/immunology*
  • Vertebrates/genetics*
  • Vertebrates/immunology*
PubMed
19559469 Full text @ Cell
Abstract
About 500 million years ago, a new type of adaptive immune defense emerged in basal jawed vertebrates, accompanied by morphological innovations, including the thymus. Did these evolutionary novelties arise de novo or from elaboration of ancient genetic networks? We reconstructed the genetic changes underlying thymopoiesis by comparative genome and expression analyses in chordates and basal vertebrates. The derived models of genetic networks were experimentally verified in bony fishes. Ancestral networks defining circumscribed regions of the pharyngeal epithelium of jawless vertebrates expanded in cartilaginous fishes to incorporate novel genes, notably those encoding chemokines. Correspondingly, novel networks evolved in lymphocytes of jawed vertebrates to control the expression of additional chemokine receptors. These complementary changes enabled unprecedented Delta/Notch signaling between pharyngeal epithelium and lymphoid cells that was exploited for specification to the T cell lineage. Our results provide a framework elucidating the evolution of key features of the adaptive immune system in jawed vertebrates.
Genes / Markers
Figures
Figure Gallery
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Errata and Notes