PUBLICATION

White adipose tissue development in zebrafish is regulated by both developmental time and fish size

Authors
Imrie, D., and Sadler, K.C.
ID
ZDB-PUB-101011-51
Date
2010
Source
Developmental dynamics : an official publication of the American Association of Anatomists   239(11): 3013-3023 (Journal)
Registered Authors
Sadler Edepli, Kirsten C.
Keywords
adipocyte, post-embryonic development, larvae, fat, histology
MeSH Terms
  • Adipocytes/cytology
  • Adipose Tissue, White/cytology*
  • Adipose Tissue, White/embryology
  • Animals
  • Body Size/genetics
  • Body Size/physiology
  • Gene Expression Regulation, Developmental/genetics
  • Gene Expression Regulation, Developmental/physiology
  • In Situ Hybridization
  • Polymerase Chain Reaction
  • Zebrafish
PubMed
20925116 Full text @ Dev. Dyn.
Abstract
Adipocytes are heterogeneous. Whether their differences are attributed to anatomical location or to different developmental origins is unknown. We investigated whether development of different white adipose tissue (WAT) depots in zebrafish occurs simultaneously or whether adipogenesis is influenced by the metabolic demands of growing fish. Like mammals, zebrafish adipocyte morphology is distinctive and adipocytes express cell-specific markers. All adults contain WAT in pancreatic, subcutaneous, visceral, esophageal, mandibular, cranial, and tail-fin depots. Unlike most zebrafish organs that form during embryogenesis, WAT was not found in embryos or young larvae. Instead, WAT was first identified in the pancreas on 12 days postfertilization (dpf), and then in visceral, subcutaneous, and cranial stores in older fish. All 30 dpf fish exceeding 10.6 mm standard length contained the adult repertoire of WAT depots. Pancreatic, esophageal, and subcutaneous WAT appearance correlated with size, not age, as found for other features appearing during postembryonic zebrafish development.
Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes