PUBLICATION
Small molecule screening in zebrafish: an in vivo approach to identifying new chemical tools and drug leads
- Authors
- Taylor, K.L., Grant, N.J., Temperley, N.D., and Patton, E.E.
- ID
- ZDB-PUB-100621-1
- Date
- 2010
- Source
- Cell communication and signaling : CCS 8: 11 (Review)
- Registered Authors
- Patton, E. Elizabeth
- Keywords
- none
- MeSH Terms
- none
- PubMed
- 20540792 Full text @ Cell Commun. Signal.
Citation
Taylor, K.L., Grant, N.J., Temperley, N.D., and Patton, E.E. (2010) Small molecule screening in zebrafish: an in vivo approach to identifying new chemical tools and drug leads. Cell communication and signaling : CCS. 8:11.
Abstract
In the past two decades, zebrafish genetic screens have identified a wealth of mutations that have been essential to the understanding of development and disease biology. More recently, chemical screens in zebrafish have identified small molecules that can modulate specific developmental and behavioural processes. Zebrafish are a unique vertebrate system in which t-o study chemical genetic systems, identify drug leads, and explore new applications for known drugs. Here, we discuss some of the advantages of using zebrafish in chemical biology, and describe some important and creative examples of small molecule screening, drug discovery and target identification.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping