PUBLICATION
Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia
- Authors
- Grabher, C., von Boehmer, H., and Look, A.T.
- ID
- ZDB-PUB-091204-3
- Date
- 2006
- Source
- Nature reviews. Cancer 6(5): 347-359 (Review)
- Registered Authors
- Grabher, Clemens, Look, A. Thomas
- Keywords
- none
- MeSH Terms
-
- Gene Expression Regulation, Leukemic*
- Humans
- Leukemia-Lymphoma, Adult T-Cell/metabolism*
- Receptor, Notch1/genetics
- Receptor, Notch1/metabolism*
- Signal Transduction
- PubMed
- 16612405 Full text @ Nat. Rev. Cancer
Citation
Grabher, C., von Boehmer, H., and Look, A.T. (2006) Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nature reviews. Cancer. 6(5):347-359.
Abstract
The chromosomal translocation t(7;9) in human T-cell acute lymphoblastic leukaemia (T-ALL) results in deregulated expression of a truncated, activated form of Notch 1 (TAN1) under the control of the T-cell receptor-beta (TCRB) locus. Although TAN1 efficiently induces T-ALL in mouse models, t(7;9) is present in less than 1% of human T-ALL cases. The recent discovery of novel activating mutations in NOTCH1 in more than 50% of human T-ALL samples has made it clear that Notch 1 is far more important in human T-ALL pathogenesis than previously suspected.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping