PUBLICATION
Chemokine signaling guides regional patterning of the first embryonic artery
- Authors
- Siekmann, A.F., Standley, C., Fogarty, K.E., Wolfe, S.A., and Lawson, N.D.
- ID
- ZDB-PUB-091023-4
- Date
- 2009
- Source
- Genes & Development 23(19): 2272-2277 (Journal)
- Registered Authors
- Lawson, Nathan, Siekmann, Arndt Friedrich, Wolfe, Scot A.
- Keywords
- Aorta, zebrafish, zinc finger nuclease, differentiation, patterning, chemokine
- MeSH Terms
-
- Signal Transduction*
- Receptors, CXCR4/deficiency
- Receptors, CXCR4/genetics
- Receptors, CXCR4/metabolism
- Zebrafish/embryology*
- Animals
- Gene Expression Regulation, Developmental
- Chemokines/physiology*
- Aorta/embryology*
- Endothelial Cells/cytology
- Body Patterning/physiology*
- PubMed
- 19797767 Full text @ Genes & Dev.
Citation
Siekmann, A.F., Standley, C., Fogarty, K.E., Wolfe, S.A., and Lawson, N.D. (2009) Chemokine signaling guides regional patterning of the first embryonic artery. Genes & Development. 23(19):2272-2277.
Abstract
The aorta traverses the body, yet little is known about how it is patterned in different anatomical locations. Here, we show that the aorta develops from genetically distinct endothelial cells originating from diverse locations within the embryo. Furthermore, chemokine (C-X-C motif) receptor 4a (cxcr4a) is restricted to endothelial cells derived from anterior mesoderm, and is required specifically for formation of the lateral aortae. Cxcl12b, a cxcr4a ligand, is expressed in endoderm underlying the lateral aortae, and loss of cxcl12b phenocopies cxcr4a deficiency. These studies reveal unexpected endothelial diversity within the aorta that is necessary to facilitate its regional patterning by local cues.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping