PUBLICATION
Identification of starmaker-like in medaka as a putative target gene of Pax2 in the otic vesicle
- Authors
- Bajoghli, B., Ramialison, M., Aghaallaei, N., Czerny, T., and Wittbrodt, J.
- ID
- ZDB-PUB-091005-9
- Date
- 2009
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 238(11): 2860-2866 (Journal)
- Registered Authors
- Aghaallaei, Narges, Bajoghli, Baubak
- Keywords
- Starmaker, otic vesicle, otoliths, medaka, zebrafish, Dspp
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Embryo, Nonmammalian/cytology
- Embryo, Nonmammalian/embryology*
- Embryo, Nonmammalian/metabolism
- Fish Proteins/genetics
- Fish Proteins/metabolism*
- Molecular Sequence Data
- Oryzias/embryology*
- Oryzias/genetics
- Oryzias/metabolism
- Otolithic Membrane/cytology
- Otolithic Membrane/embryology*
- Otolithic Membrane/metabolism
- PAX2 Transcription Factor/genetics
- PAX2 Transcription Factor/metabolism*
- PubMed
- 19795520 Full text @ Dev. Dyn.
Citation
Bajoghli, B., Ramialison, M., Aghaallaei, N., Czerny, T., and Wittbrodt, J. (2009) Identification of starmaker-like in medaka as a putative target gene of Pax2 in the otic vesicle. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(11):2860-2866.
Abstract
Otoliths in bony fishes are involved in the function of the ear in the senses of balance and hearing. In a large-scale random in situ hybridization screen of genes expressed in the medaka developing ear, we identified starmaker-like (stm-l) gene, a novel homologue of zebrafish starmaker and human dentine sialo-phosphoprotein (dspp) gene. Despite the absence of sequence similarity between these genes, here we describe their similar genomic structure and expression patterns hinting for a conserved function. In medaka fry, stm-l is expressed in various organs such as otoliths, teeth, gills, and kidney. Additionally, our results provide evidence that stm-l is a putative downstream target gene of Pax2 transcription factor and Pax2 itself has a promoting function in otolith formation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping