|ZFIN ID: ZDB-PUB-090914-38|
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N-CoR is required for patterning the anterior-posterior axis of zebrafish hindbrain by actively repressing retinoid signaling
Xu, F., Li, K., Tian, M., Hu, P., Song, W., Chen, J., Gao, X., and Zhao, Q.
|Source:||Mechanisms of Development 126(10): 771-780 (Journal)|
|Registered Authors:||Hu, Ping, Song, Wei, Xu, Fang, Zhao, Qingshun|
|Keywords:||Zebrafish, N-CoR, Retinoid signaling, Hindbrain, Anterior-posterior axis, Rhombomere, Cyp26A1, Aldh1a2, Hox|
|PubMed:||19735730 Full text @ Mech. Dev.|
Xu, F., Li, K., Tian, M., Hu, P., Song, W., Chen, J., Gao, X., and Zhao, Q. (2009) N-CoR is required for patterning the anterior-posterior axis of zebrafish hindbrain by actively repressing retinoid signaling. Mechanisms of Development. 126(10):771-780.
ABSTRACTActive repression of gene expression mediated by unliganded nuclear receptors plays crucial roles in early development of vertebrate. N-CoR (nuclear receptor co-repressor) is the first identified co-repressor that can repress retinoic acid (RA) inducible gene transcription in the absence of RA. Previously, N-CoR was reported to be required for late-stage organogenesis in mouse but whether N-CoR can affect RA-responsive early embryonic patterning is unknown. In this study, we report molecular cloning of zebrafish orthologue of N-CoR and its wide distribution pattern during zebrafish early development. Knocking down n-cor elevates endogenous RA signaling in zebrafish embryos and posteriorizes the neural ectoderm. Overexpressing or knocking down n-cor in zebrafish embryos alters the length of hindbrain in a manner similar to decreasing or increasing RA signaling in embryos respectively. Taken together, our results demonstrate that N-CoR is essential for early hindbrain patterning by actively repressing retinoid signaling.