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ZFIN ID: ZDB-PUB-090616-2
The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axis
Tucker, J.A., Mintzer, K.A., and Mullins, M.C.
Date: 2008
Source: Developmental Cell   14(1): 108-119 (Journal)
Registered Authors: Mintzer, Keith A., Mullins, Mary C.
Keywords: DEVBIO
MeSH Terms:
  • Animals
  • Body Patterning/genetics
  • Body Patterning/physiology*
  • Bone Morphogenetic Proteins/genetics
  • Bone Morphogenetic Proteins/physiology*
  • Brain/embryology
  • Chick Embryo/physiology
  • Chickens
  • Embryo, Nonmammalian/physiology
  • Embryonic Development
  • In Situ Hybridization
  • Models, Biological
  • Phenotype
  • Signal Transduction
  • Vertebrates/embryology*
PubMed: 18194657 Full text @ Dev. Cell
Patterning of the vertebrate anteroposterior (AP) axis proceeds temporally from anterior to posterior. How dorsoventral (DV) axial patterning relates to AP temporal patterning is unknown. We examined the temporal activity of BMP signaling in patterning ventrolateral cell fates along the AP axis, using transgenes that rapidly turn "off" or "on" BMP signaling. We show that BMP signaling patterns rostral DV cell fates at the onset of gastrulation, whereas progressively more caudal DV cell fates are patterned at progressively later intervals during gastrulation. Increased BMP signal duration is not required to pattern more caudal DV cell fates; rather, distinct temporal intervals of signaling are required. This progressive action is regulated downstream of, or in parallel to, BMP signal transduction at the level of Smad1/5 phosphorylation. We propose that a temporal cue regulates a cell's competence to respond to BMP signaling, allowing the acquisition of a cell's DV and AP identity simultaneously.