ZFIN ID: ZDB-PUB-090319-10
ccbe1 is required for embryonic lymphangiogenesis and venous sprouting
Hogan, B.M., Bos, F.L., Bussmann, J., Witte, M., Chi, N.C., Duckers, H.J., and Schulte-Merker, S.
Date: 2009
Source: Nature Genetics   41(4): 396-398 (Journal)
Registered Authors: Bos, Frank, Bussmann, Jeroen, Hogan, Ben M., Schulte-Merker, Stefan, Witte, Merlijn
Keywords: none
MeSH Terms:
  • Amino Acid Substitution
  • Animals
  • Binding Sites
  • Calcium/metabolism
  • Cell Division
  • Cell Movement
  • Embryo, Nonmammalian/physiology
  • Embryonic Development
  • Epidermal Growth Factor/genetics*
  • Humans
  • Lymphangiogenesis/genetics*
  • Lymphatic Vessels/cytology
  • Lymphatic Vessels/embryology
  • Lymphatic Vessels/physiology*
  • Models, Animal
  • Mutation*
  • Vascular Endothelial Growth Factor C/genetics
  • Zebrafish
PubMed: 19287381 Full text @ Nat. Genet.
Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.