PUBLICATION

The role of the ETS factor erg in zebrafish vasculogenesis

Authors
Ellett, F., Kile, B.T., and Lieschke, G.J.
ID
ZDB-PUB-081203-7
Date
2009
Source
Mechanisms of Development   126(3-4): 220-229 (Journal)
Registered Authors
Ellett, Felix, Lieschke, Graham J.
Keywords
none
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Blood Vessels/cytology
  • Blood Vessels/embryology*
  • Blood Vessels/metabolism
  • Body Patterning
  • Cell Proliferation
  • Conserved Sequence
  • Ether-A-Go-Go Potassium Channels/chemistry
  • Ether-A-Go-Go Potassium Channels/genetics
  • Ether-A-Go-Go Potassium Channels/metabolism*
  • Gene Expression Regulation, Developmental
  • Mesoderm/cytology
  • Mesoderm/metabolism
  • Models, Biological
  • Molecular Sequence Data
  • Morphogenesis*
  • Phylogeny
  • Proto-Oncogene Proteins c-ets/chemistry
  • Proto-Oncogene Proteins c-ets/genetics
  • Proto-Oncogene Proteins c-ets/metabolism*
  • Sequence Analysis, Protein
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish Proteins/chemistry
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
PubMed
19027849 Full text @ Mech. Dev.
Abstract
Erg, a member of the ETS family of transcription factors, has been implicated by previous studies in endothelial and haematopoietic development. Deregulation of the human ERG locus is associated with acute myeloid leukaemia, prostate cancer and Ewing's sarcoma. To better understand the role of Erg during early development, we utilised the zebrafish as a model amenable to descriptive and functional studies in vivo. Zebrafish have a single erg gene that is expressed in mesoderm and its vascular derivatives during angioblast migration, vasculogenesis and early angiogenesis. Mutant and morphant expression analyses placed erg in a genetic pathway downstream of cloche, tal1/scl and etsrp during early angioblast migration. Furthermore, a combination of gain-of-function and loss-of-function studies suggested a redundant yet specific role for erg in both angioblast specification/proliferation and early angiogenesis, and a synergistic interaction with the critical ETS factor etsrp.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes