ZFIN Person: Ellett, Felix

ZFIN ID: ZDB-PERS-060425-1

Ellett, Felix

Email:	fellett@mgh.harvard.edu
URL:	https://www.linkedin.com/in/felix-ellett-693274b9
Affiliation:
Address:	Massachusetts General Hospital BioMEMS Resource Center Room 1407, Building 114, 16th Street Charlestown, MA. 02129 USA
Country:
Phone:	+1 6177243209
Fax:
ORCID ID:	0000-0003-4941-4346

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Da Silveira Cavalcante, L., Lopera Higuita, M., González-Rosa, J.M., Marques, B., To, S., Pendexter, C.A., Cronin, S.E.J., Gopinathan, K., de Vries, R.J., Ellett, F., Uygun, K., Langenau, D.M., Toner, M., Tessier, S.N. (2024) Erratum to "Zebrafish as a high throughput model for organ preservation and transplantation research". FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 38:e23335e23335

Da Silveira Cavalcante, L., Lopera Higuita, M., González-Rosa, J.M., Marques, B., To, S., Pendexter, C.A., Cronin, S.E.J., Gopinathan, K., de Vries, R.J., Ellett, F., Uygun, K., Langenau, D.M., Toner, M., Tessier, S.N. (2023) Zebrafish as a high throughput model for organ preservation and transplantation research. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e23187e23187

Ellett, F., Kacamak, N.I., Alvarez, C.R., Oliveira, E.H.S., Hasturk, H., Paster, B.J., Kantarci, A., Irimia, D. (2023) Fusobacterium nucleatum dissemination by neutrophils. Journal of oral microbiology. 15:22170672217067

Sipka, T., Peroceschi, R., Hassan-Abdi, R., Groß, M., Ellett, F., Begon-Pescia, C., Gonzalez, C., Lutfalla, G., Nguyen-Chi, M. (2021) Damage-Induced Calcium Signaling and Reactive Oxygen Species Mediate Macrophage Activation in Zebrafish. Frontiers in immunology. 12:636585

Plant, T., Eamsamarng, S., Sanchez-Garcia, M.A., Reyes, L., Renshaw, S.A., Coelho, P., Mirchandani, A.S., Morgan, J.M., Ellett, F.E., Morrison, T., Humphries, D., Watts, E.R., Murphy, F., Raffo-Iraolagoitia, X.L., Zhang, A., Cash, J.L., Loynes, C., Elks, P.M., Van Eeden, F., Carlin, L.M., Furley, A.J.W., Whyte, M.K.B., Walmsley, S.R. (2020) Semaphorin 3F signaling actively retains neutrophils at sites of inflammation. The Journal of Clinical Investigation. 130(6):3221-3237

Pazhakh, V., Ellett, F., Croker, B.A., O'Donnell, J.A., Pase, L., Schulze, K.E., Greulich, R.S., Gupta, A., Reyes-Aldasoro, C.C., Andrianopoulos, A., Lieschke, G.J. (2019) β-glucan-dependent shuttling of conidia from neutrophils to macrophages occurs during fungal infection establishment. PLoS Biology. 17:e3000113

Tsai, T.Y., Collins, S.R., Chan, C.K., Hadjitheodorou, A., Lam, P.Y., Lou, S.S., Yang, H.W., Jorgensen, J., Ellett, F., Irimia, D., Davidson, M.W., Fischer, R.S., Huttenlocher, A., Meyer, T., Ferrell, J.E., Theriot, J.A. (2019) Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization. Developmental Cell. 49:189-205.e6

Jones, C.N., Ellett, F., Robertson, A.L., Forrest, K.M., Judice, K., Balkovec, J.M., Springer, M., Markmann, J.F., Vyas, J.M., Warren, H.S., Irimia, D. (2019) Bifunctional Small Molecules Enhance Neutrophil Activities Against Aspergillus fumigatus in vivo and in vitro. Frontiers in immunology. 10:644

Loynes, C.A., Lee, J.A., Robertson, A.L., Steel, M.J., Ellett, F., Feng, Y., Levy, B.D., Whyte, M.K.B., Renshaw, S.A. (2018) PGE₂ production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo.. Science advances. 4:eaar8320

Ellett, F., Pazhakh, V., Pase, L., Benard, E.L., Weerasinghe, H., Azabdaftari, D., Alasmari, S., Andrianopoulos, A., Lieschke, G.J. (2018) Macrophages protect Talaromyces marneffei conidia from myeloperoxidase-dependent neutrophil fungicidal activity during infection establishment in vivo. PLoS pathogens. 14:e1007063

Ellett, F., Irimia, D. (2017) Microstructured Devices for Optimized Microinjection and Imaging of Zebrafish Larvae. Journal of visualized experiments : JoVE. (130)

Ellett, F., Irimia, D. (2017) Microstructured Surface Arrays for Injection of Zebrafish Larvae. Zebrafish. 14(2):140-145

Bhuiyan, M.S., Ellett, F., Murray, G.L., Kostoulias, X., Cerqueira, G.M., Schulze, K.E., Mahamad Maifiah, M.H., Li, J., Creek, D.J., Lieschke, G.J., Peleg, A.Y. (2016) Acinetobacter baumannii phenylacetic acid metabolism influences infection outcome through a direct effect on neutrophil chemotaxis. Proceedings of the National Academy of Sciences of the United States of America. 113(34):9599-604

Ellett, F., Elks, P.M., Robertson, A.L., Ogryzko, N.V., Renshaw, S.A. (2015) Defining the phenotype of neutrophils following reverse migration in zebrafish. Journal of Leukocyte Biology. 98(6):975-81

Keatinge, M., Bui, H., Menke, A., Chen, Y.C., Sokol, A.M., Bai, Q., Ellett, F., Da Costa, M., Burke, D., Gegg, M., Trollope, L., Payne, T., McTighe, A., Mortiboys, H., de Jager, S., Nuthhall, H., Kuo, M.S., Fleming, A., Schapira, A.H., Renshaw, S.A., Highley, J.R., Chacinska, A., Panula, P., Burton, E.A., O'Neill, M.J., Bandmann, O. (2015) Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death. Human molecular genetics. 24(23):6640-52

Okuda, K.S., Misa, J.P., Oehlers, S.H., Hall, C.J., Ellett, F., Alasmari, S., Lieschke, G.J., Crosier, K.E., Crosier, P.S., Astin, J.W. (2015) A zebrafish model of inflammatory lymphangiogenesis. Biology Open. 4(10):1270-80

Pagán, A.J., Yang, C.T., Cameron, J., Swaim, L.E., Ellett, F., Lieschke, G.J., Ramakrishnan, L. (2015) Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment. Cell Host & Microbe. 18:15-26

Hall, C.J., Boyle, R.H., Astin, J.W., Flores, M.V., Oehlers, S.H., Sanderson, L.E., Ellett, F., Lieschke, G.J., Crosier, K.E., and Crosier, P.S. (2013) Immunoresponsive Gene 1 Augments Bactericidal Activity of Macrophage-Lineage Cells by Regulating β-Oxidation-Dependent Mitochondrial ROS Production. Cell Metabolism. 18(2):265-278

Palha, N., Guivel-Benhassine, F., Briolat, V., Lutfalla, G., Sourisseau, M., Ellett, F., Wang, C.H., Lieschke, G.J., Herbomel, P., Schwartz, O., and Levraud, J.P. (2013) Real-time whole-body visualization of chikungunya virus infection and host interferon response in zebrafish. PLoS pathogens. 9(9):e1003619

Svahn, A.J., Graeber, M.B., Ellett, F., Lieschke, G.J., Rinkwitz, S., Bennett, M.R., and Becker, T.S. (2013) Development of ramified microglia from early macrophages in the zebrafish optic tectum. Developmental Neurobiology. 73(1):60-71

Pase, L., Layton, J.E., Wittmann, C., Ellett, F., Nowell, C.J., Reyes-Aldasoro, C.C., Varma, S., Rogers, K.L., Hall, C.J., Keightley, M.C., Crosier, P.S., Grabher, C., Heath, J.K., Renshaw, S.A., and Lieschke, G.J. (2012) Neutrophil-Delivered Myeloperoxidase Dampens the Hydrogen Peroxide Burst after Tissue Wounding in Zebrafish. Current biology : CB. 22(19):1818-1824

Goldshmit, Y., Matteo, R., Sztal, T., Ellett, F., Frisca, F., Moreno, K., Crombie, D., Lieschke, G.J., Currie, P.D., Sabbadini, R.A., and Pebay, A. (2012) Blockage of Lysophosphatidic Acid Signaling Improves Spinal Cord Injury Outcomes. The American journal of pathology. 181(3):978-992

Benard, E.L., van der Sar, A.M., Ellett, F., Lieschke, G.J., Spaink, H.P., and Meijer, A.H. (2012) Infection of zebrafish embryos with intracellular bacterial pathogens. Journal of visualized experiments : JoVE. (61)

Dworkin, S., Darido, C., Georgy, S.R., Wilanowski, T., Srivastava, S., Ellett, F., Pase, L., Han, Y., Meng, A., Heath, J.K., Lieschke, G.J., and Jane, S.M. (2012) Midbrain-hindbrain boundary patterning and morphogenesis are regulated by diverse grainy head-like 2-dependent pathways. Development (Cambridge, England). 139(3):525-536

Ellett, F., and Lieschke, G.J. (2012) Computational quantification of fluorescent leukocyte numbers in zebrafish embryos. Methods in enzymology. 506:425-435

Fang, L., Green, S.R., Baek, J.S., Lee, S.H., Ellett, F., Deer, E., Lieschke, G.J., Witztum, J.L., Tsimikas, S., and Miller, Y.I. (2011) In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish. J. Clin. Invest.. 121(12):4861-9

Ellett, F., Pase, L., Hayman, J.W., Andrianopoulos, A., and Lieschke, G.J. (2011) mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish. Blood. 117(4):e49-e56

Ellett, F., and Lieschke, G.J. (2010) Zebrafish as a model for vertebrate hematopoiesis. Current opinion in pharmacology. 10(5):563--570

Ellett, F., Kile, B.T., and Lieschke, G.J. (2009) The role of the ETS factor erg in zebrafish vasculogenesis. Mechanisms of Development. 126(3-4):220-229

NON-ZEBRAFISH PUBLICATIONS