PUBLICATION

Molecular diversity of connexin and pannexin genes in the retina of the zebrafish Danio rerio

Authors
Zoidl, G., Kremer, M., Zoidl, C., Bunse, S., and Dermietzel, R.
ID
ZDB-PUB-080728-11
Date
2008
Source
Cell communication & adhesion   15(1): 169-183 (Journal)
Registered Authors
Zoidl, Georg
Keywords
connexin, gap junction, pannexin, retina, vision, zebrafish
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Cloning, Molecular
  • Connexins/genetics*
  • Connexins/metabolism
  • Conserved Sequence
  • Gap Junctions/metabolism
  • Genetic Variation*
  • Humans
  • Molecular Sequence Data
  • Protein Isoforms/genetics
  • Protein Isoforms/metabolism
  • Retina/metabolism*
  • Zebrafish/genetics*
  • Zebrafish/metabolism
PubMed
18649188 Full text @ Cell Commun. Adhes.
Abstract
Gap junctions are among the most widely distributed cell structures involved in cell-to-cell communication. Recently completed genome sequencing projects including species from all major phyla have demonstrated the existence of three distinct gene families, the connexins, pannexins, and innexins, as molecular building blocks of gap junctional communication. In the present study, the authors have addressed the molecular complexity of gap junction gene expression in the zebrafish retina, a remarkably complex sensory organ built by diverse neuronal subtypes. Using a combination of cDNA library and genomic DNA library screening and/or RACE technology, the authors have cloned, in addition to the four previously reported connexins, seven novel connexins and four pannexin transcripts resembling two pannexin genes. This result demonstrates the presence of two distinct gap junction type gene families and indicates a remarkable molecular and functional diversity of gap junction-mediated coupling in the fish retina.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes