PUBLICATION
Tuning in to the signals: noncoding sequence conservation in vertebrate genomes
- Authors
- Elgar, G., and Vavouri, T.
- ID
- ZDB-PUB-080610-5
- Date
- 2008
- Source
- Trends in genetics : TIG 24(7): 344-352 (Review)
- Registered Authors
- Elgar, Greg
- Keywords
- none
- MeSH Terms
-
- Animals
- Computational Biology
- Conserved Sequence*
- DNA, Intergenic/genetics*
- Genome/genetics*
- Humans
- Invertebrates/genetics
- Vertebrates/genetics*
- PubMed
- 18514361 Full text @ Trends Genet.
Citation
Elgar, G., and Vavouri, T. (2008) Tuning in to the signals: noncoding sequence conservation in vertebrate genomes. Trends in genetics : TIG. 24(7):344-352.
Abstract
Aligning and comparing genomic sequences enables the identification of conserved sequence signatures and can enrich for coding and noncoding functional regions. In vertebrates, the comparison of human and rodent genomes and the comparison of evolutionarily distant genomes, such as human and pufferfish, have identified specific sets of 'ultraconserved' sequence elements associated with the control of early development. However, is this just the tip of a 'conservation iceberg' or do these sequences represent a specific class of regulatory element? Studies on the zebrafish phox2b gene region and the ENCODE project suggest that many regulatory elements are not highly conserved, posing intriguing questions about the relationship between noncoding sequence conservation and function and the evolution of regulatory sequences.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping