ZFIN Person: Elgar, Greg

ZFIN ID: ZDB-PERS-040810-18

Elgar, Greg

Email:	G.Elgar@qmul.ac.uk
URL:
Affiliation:	Elgar Lab - Fugu Comparative Genomics Group
Address:	Rosalind Franklin Centre for Genomics Research Wellcome Trust Genome Campus Hinxton Cambridge, CB10 1SB United Kingdom
Country:	United Kingdom
Phone:
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Pauls, S., Goode, D.K., Petrone, L., Oliveri, P., Elgar, G. (2015) Evolution of lineage-specific functions in ancient cis-regulatory modules. Open Biology. 5(11)

Anwar, S., Minhas, R., Ali, S., Lambert, N., Kawakami, Y., Elgar, G., Azam, S.S., Abbasi, A.A. (2015) Identification and functional characterization of novel transcriptional enhancers involved in regulating human GLI3 expression during early development. Development, growth & differentiation. 57(8):570-80

Grice, J., Noyvert, B., Doglio, L., Elgar, G. (2015) A Simple Predictive Enhancer Syntax for Hindbrain Patterning Is Conserved in Vertebrate Genomes. PLoS One. 10:e0130413

Minhas, R., Pauls, S., Ali, S., Doglio, L., Khan, M.R., Elgar, G., Abbasi, A.A. (2015) Cis-regulatory control of human GLI2 expression in the developing neural tube and limb bud. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(5):681-92

Chen, W.C., Pauls, S., Bacha, J., Elgar, G., Loose, M., Shimeld, S.M. (2014) Dissection of a Ciona regulatory element reveals complexity of cross-species enhancer activity. Developmental Biology. 390:261-72

Doglio, L., Goode, D.K., Pelleri, M.C., Pauls, S., Frabetti, F., Shimeld, S.M., Vavouri, T., and Elgar, G. (2013) Parallel evolution of chordate cis-regulatory code for development. PLoS Genetics. 9(11):e1003904

Pauls, S., Smith, S.F., and Elgar, G. (2012) Lens development depends on a pair of highly conserved Sox21 regulatory elements. Developmental Biology. 365(1):310-318

Parker, H.J., Piccinelli, P., Sauka-Spengler, T., Bronner, M., and Elgar, G. (2011) Ancient Pbx-Hox Signatures Define Hundreds of Vertebrate Developmental Enhancers. BMC Genomics. 12(1):637

Goode, D.K., Callaway, H.A., Cerda, G.A., Lewis, K.E., and Elgar, G. (2011) Minor change, major difference: divergent functions of highly conserved cis-regulatory elements subsequent to whole genome duplication events. Development (Cambridge, England). 138(5):879-884

Kenyon, E.J., McEwen, G.K., Callaway, H., and Elgar, G. (2011) Functional Analysis of Conserved Non-Coding Regions Around the Short Stature hox Gene (shox) in Whole Zebrafish Embryos. PLoS One. 6(6):e21498

McEwen, G.K., Goode, D.K., Parker, H.J., Woolfe, A., Callaway, H., and Elgar, G. (2009) Early evolution of conserved regulatory sequences associated with development in vertebrates. PLoS Genetics. 5(12):e1000762

Elgar, G., and Vavouri, T. (2008) Tuning in to the signals: noncoding sequence conservation in vertebrate genomes. Trends in genetics : TIG. 24(7):344-352

Ikeda, D., Ono, Y., Snell, P., Edwards, Y.J., Elgar, G., and Watabe, S. (2007) Divergent evolution of the myosin heavy chain gene family in fish and tetrapods: evidence from comparative genomic analysis. Physiological Genomics. 32(1):1-15

Woolfe, A., Goode, D.K., Cooke, J., Callaway, H., Smith, S., Snell, P., McEwen, G.K., and Elgar, G. (2007) CONDOR: a database resource of developmentally associated conserved non-coding elements. BMC Developmental Biology. 7(1):100

Paparidis, Z., Abbasi, A.A., Malik, S., Goode, D.K., Callaway, H., Elgar, G., Degraaff, E., Lopez-Rios, J., Zeller, R., and Grzeschik, K.H. (2007) Ultraconserved non-coding sequence element controls a subset of spatiotemporal GLI3 expression. Development, growth & differentiation. 49(6):543-553

Abbasi, A.A., Paparidis, Z., Malik, S., Goode, D.K., Callaway, H., Elgar, G., and Grzeschik, K.H. (2007) Human GLI3 Intragenic Conserved Non-Coding Sequences Are Tissue-Specific Enhancers. PLoS One. 2(1):e366

Woolfe, A., and Elgar, G. (2007) Comparative genomics using Fugu reveals insights into regulatory subfunctionalization. Genome biology. 8(4):R53

Elgar, G. (2006) Different words, same meaning: understanding the languages of the genome. Trends in genetics : TIG. 22(12):639-641

McEwen, G.K., Woolfe, A., Goode, D., Vavouri, T., Callaway, H., and Elgar, G. (2006) Ancient duplicated conserved noncoding elements in vertebrates: a genomic and functional analysis. Genome research. 16(4):451-465

Goode, D.K., Snell, P., Smith, S.F., Cooke, J.E., and Elgar, G. (2005) Highly conserved regulatory elements around the SHH gene may contribute to the maintenance of conserved synteny across human chromosome 7q36.3. Genomics. 86(2):172-181

Kopeika, J., Zhang, T., Rawson, D.M., and Elgar, G. (2005) Effect of cryopreservation on mitochondrial DNA of zebrafish (Danio rerio) blastomere cells. Mutation research. 570(1):49-61

Woolfe, A., Goodson, M., Goode, D.K., Snell, P., McEwen, G.K., Vavouri, T., Smith, S.F., North, P., Callaway, H., Kelly, K., Walter, K., Abnizova, I., Gilks, W., Edwards, Y.J., Cooke, J.E., and Elgar, G. (2005) Highly conserved non-coding sequences are associated with vertebrate development. PLoS Biology. 3(1):e7

Miles, C.G., Rankin, L., Smith, S.I., Niksic, M., Elgar, G., and Hastie, N.D. (2003) Faithful expression of a tagged Fugu WT1 protein from a genomic transgene in zebrafish: efficient splicing of pufferfish genes in zebrafish but not mice. Nucleic acids research. 31(11):2795-2802

Sambrook, J.G., Russell, R., Umrania, Y., Edwards, Y.J., Campbell, R.D., Elgar, G., and Clark, M.S. (2002) Fugu orthologues of human major histocompatibility complex genes: a genome survey. Immunogenetics. 54(6):367-380

Smith, S.F., Snell, P., Gruetzner, F., Bench, A.J., Haaf, T., Metcalfe, J.A., Green, A.R., and Elgar, G. (2002) Analyses of the extent of shared synteny and conserved gene orders between the genome of Fugu rubripes and human 20q. Genome research. 12(5):776-784

Clark, M.S., Shaw, L., Kelly, A., Snell, P., and Elgar, G. (2001) Characterization of the MHC class I region of the Japanese pufferfish (Fugu rubripes). Immunogenetics. 52(3-4):174-185

NON-ZEBRAFISH PUBLICATIONS