PUBLICATION
Precious metal economy
- Authors
- Merchant, S.S., and Sagasti, A.
- ID
- ZDB-PUB-060816-8
- Date
- 2006
- Source
- Cell Metabolism 4(2): 99-101 (Journal)
- Registered Authors
- Sagasti, Alvaro
- Keywords
- none
- MeSH Terms
-
- Animals
- Zebrafish
- Disease Models, Animal
- Menkes Kinky Hair Syndrome/etiology
- Menkes Kinky Hair Syndrome/genetics*
- Menkes Kinky Hair Syndrome/metabolism*
- Humans
- Copper/metabolism*
- PubMed
- 16890535 Full text @ Cell Metab.
Citation
Merchant, S.S., and Sagasti, A. (2006) Precious metal economy. Cell Metabolism. 4(2):99-101.
Abstract
The zebrafish is emerging as a system of choice for modeling human disease. In this issue of Cell Metabolism, describe a model for Menkes disease, a genetic disorder in copper utilization. Using genetic and chemical screens, the authors highlight the impact of maternal nutrition on embryo development. The work reveals a hierarchy of temporal and dosage-dependent phenotypes for copper nutrition.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping