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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-020116-3
Sagasti, Alvaro
Email: sagasti@mcdb.ucla.edu
URL: http://www.mcdb.ucla.edu/Research/Sagasti/
Affiliation: Sagasti lab
Address: Department of MCD Biology UCLA Life Science Building 4226 P.O. Box 951606 Los Angeles, CA 90095-1606 USA
Country: United States
Phone: 310-206-6147
Fax: 310-206-3987
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Rasmussen, J.P., Vo, N.T., Sagasti, A. (2018) Fish Scales Dictate the Pattern of Adult Skin Innervation and Vascularization. Developmental Cell. 46(3):344-359.e4
Madigan, C.A., Cambier, C.J., Kelly-Scumpia, K.M., Scumpia, P.O., Cheng, T.Y., Zailaa, J., Bloom, B.R., Moody, D.B., Smale, S.T., Sagasti, A., Modlin, R.L., Ramakrishnan, L. (2017) A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy. Cell. 170:973-985.e10
Rasmussen, J.P., Sagasti, A. (2017) Learning to swim, again: Axon regeneration in fish. Experimental neurology. 287(Pt 3):318-330
Lulla, A., Barnhill, L., Bitan, G., Ivanova, M.I., Nguyen, B., O'Donnell, K., Stahl, M.C., Yamashiro, C., Klärner, F.G., Schrader, T., Sagasti, A., Bronstein, J.M. (2016) Neurotoxicity of the Parkinson's Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos. Environmental health perspectives. 124(11):1766-1775
Vargas, M.E., Yamagishi, Y., Tessier-Lavigne, M., Sagasti, A. (2015) Live Imaging of Calcium Dynamics during Axon Degeneration Reveals Two Functionally Distinct Phases of Calcium Influx. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:15026-38
Rasmussen, J.P., Sack, G.S., Martin, S.M., Sagasti, A. (2015) Vertebrate epidermal cells are broad-specificity phagocytes that clear sensory axon debris. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:559-70
Julien, D.P., Sagasti, A. (2014) Synaptic Specificity: When the Neighbors Are Away, Sensory Axons Turn Promiscuous. Current biology : CB. 24:R1168-R1170
Chun, R.F., Blatter, E., Elliott, S., Fitz-Gibbon, S., Rieger, S., Sagasti, A., Adams, J.S., Hewison, M. (2014) Cloning of a functional 25-hydroxyvitamin D-1α-hydroxylase in zebrafish (Danio rerio). Cell biochemistry and function. 32(8):675-82
O'Donnell, K.C., Lulla, A., Stahl, M.C., Wheat, N.D., Bronstein, J.M., Sagasti, A. (2014) Axon degeneration and PGC-1alpha-mediated protection in a zebrafish model of alpha-synuclein toxicity. Disease models & mechanisms. 7:571-82
O'Donnell, K.C., Vargas, M.E., and Sagasti, A. (2013) WldS and PGC-1alpha Regulate Mitochondrial Transport and Oxidation State after Axonal Injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(37):14778-14790
Palanca, A.M., Lee, S.L., Yee, L.E., Joe-Wong, C., Trinh, L.A., Hiroyasu, E., Husain, M., Fraser, S.E., Pellegrini, M., and Sagasti, A. (2013) New transgenic reporters identify somatosensory neuron subtypes in larval zebrafish. Developmental Neurobiology. 73(2):152-167
Palanca, A.M., and Sagasti, A. (2013) Optogenetic Activation of Zebrafish Somatosensory Neurons using ChEF-tdTomato. Journal of visualized experiments : JoVE. (71):e50184
Fitzmaurice, A.G., Rhodes, S.L., Lulla, A., Murphy, N.P., Lam, H.A., O'Donnell, K.C., Barnhill, L., Casida, J.E., Cockburn, M., Sagasti, A., Stahl, M.C., Maidment, N.T., Ritz, B., and Bronstein, J.M. (2013) Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. 110(2):636-641
Issa, F.A., Mock, A.F., Sagasti, A., and Papazian, D.M. (2012) Spinocerebellar ataxia type 13 mutation associated with disease onset in infancy disrupts axonal pathfinding during neuronal development. Disease models & mechanisms. 5(6):921-929
Villegas, R., Martin, S.M., O'Donnell, K., Carrillo, S., Sagasti, A., and Allende, M.L. (2012) Dynamics of degeneration and regeneration in developing zebrafish peripheral axons reveals a requirement for extrinsic cell types. Neural Development. 7(1):19
Wang, F., Wolfson, S.N., Gharib, A., and Sagasti, A. (2012) LAR Receptor Tyrosine Phosphatases and HSPGs Guide Peripheral Sensory Axons to the Skin. Current biology : CB. 22(5):373-382
O'Brien, G.S., Rieger, S., Wang, F., Smolen, G.A., Gonzalez, R.E., Buchanan, J., and Sagasti, A. (2012) Coordinate development of skin cells and cutaneous sensory axons in zebrafish. The Journal of comparative neurology. 520(4):816-31
Rieger, S., Wang, F., and Sagasti, A. (2011) Time-lapse imaging of neural development: Zebrafish lead the way into the fourth dimension. Genesis (New York, N.Y. : 2000). 49(7):534-45
Rieger, S., and Sagasti, A. (2011) Hydrogen peroxide promotes injury-induced peripheral sensory axon regeneration in the zebrafish skin. PLoS Biology. 9(5):e1000621
Issa, F.A., O'Brien, G., Kettunen, P., Sagasti, A., Glanzman, D.L., Papazian, D.M. (2011) Neural circuit activity in freely behaving zebrafish (Danio rerio). The Journal of experimental biology. 213(Pt 6):1028-1038
Martin, S.M., O'Brien, G.S., Portera-Cailliau, C., and Sagasti, A. (2010) Wallerian degeneration of zebrafish trigeminal axons in the skin is required for regeneration and developmental pruning. Development (Cambridge, England). 137(23):3985-3994
O'Brien, G.S., Martin, S.M., Söllner, C., Wright, G.J., Becker, C.G., Portera-Cailliau, C., and Sagasti, A. (2009) Developmentally Regulated Impediments to Skin Reinnervation by Injured Peripheral Sensory Axon Terminals. Current biology : CB. 19(24):2086-2090
Sagasti, A., O'Brien, G.S., Rieger, S., Martin, S.M., Cavanaugh, A.M., and Portera-Cailliau, C. (2009) Two-photon axotomy and time-lapse confocal imaging in live zebrafish embryos. Journal of visualized experiments : JoVE. (24)
Merchant, S.S., and Sagasti, A. (2006) Precious metal economy. Cell Metabolism. 4(2):99-101
Sagasti, A., Guido, M.R., Raible, D.W., and Schier, A.F. (2005) Repulsive interactions shape the morphologies and functional arrangement of zebrafish peripheral sensory arbors. Current biology : CB. 15(9):804-814

NON-ZEBRAFISH PUBLICATIONS
Tanaka-Hino, M., Sagasti, A., Hisamoto, N., Kawasaki, M., Nakano, S., Ninomiya-Tsuji, J., Bargmann, C., and K. Matsumoto (2002). SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans. EMBO Rep. 3: 56-62.

Sagasti, A., Hisamoto, N., Hyodo, J., Tanaka-Hino, M., Matsumoto, K. and C.I. Bargmann (2001). The CaMKII UNC-43 activates the MAPKKK NSY-1 to execute a lateral signaling pathway that determines asymmetric olfactory neuron fates. Cell 105: 221-232.

Troemel, E.R.*, Sagasti, A.*, and C.I. Bargmann (1999). Lateral signaling mediated by axon contact and calcium entry regulates asymmetric odorant receptor expression in C. elegans. Cell 99: 387-398. *These authors contributed equally to this work.

Sagasti, A., Hobert, O., Troemel, E.R., Ruvkun, G., and C.I. Bargmann (1999). Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4. Genes & Development 13: 17941806.

Roayaie, K., Crump, J.G., Sagasti, A., and C.I. Bargmann (1998). The G-alpha protein ODR-3 mediates olfactory and nociceptive function and controls cilium morphogenesis in C. elegans olfactory neurons. Neuron 20: 55-67.