PUBLICATION
Divergence in regulation of the PEA3 family of ETS transcription factors
- Authors
- Roussigne, M., and Blader, P.
- ID
- ZDB-PUB-060315-1
- Date
- 2006
- Source
- Gene expression patterns : GEP 6(8): 777-782 (Journal)
- Registered Authors
- Blader, Patrick, Roussigné, Myriam
- Keywords
- Zebrafish, PEA3 family, er81, FGF, Evolution
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Cloning, Molecular
- Embryo, Nonmammalian
- Fibroblast Growth Factors/metabolism
- Gene Expression Regulation, Developmental
- Molecular Sequence Data
- Phylogeny
- Proto-Oncogene Proteins c-ets/genetics
- Proto-Oncogene Proteins c-ets/metabolism*
- Sequence Homology, Amino Acid
- Transcription Factors/metabolism*
- Zebrafish/embryology
- Zebrafish/genetics*
- Zebrafish/metabolism*
- Zebrafish Proteins/genetics
- PubMed
- 16516559 Full text @ Gene Expr. Patterns
Citation
Roussigne, M., and Blader, P. (2006) Divergence in regulation of the PEA3 family of ETS transcription factors. Gene expression patterns : GEP. 6(8):777-782.
Abstract
Here, we report the cloning of a cDNA encoding zebrafish ER81, a member of the PEA3 family of Ets transcription factors. Strikingly, the spatial and temporal expression of er81 is significantly different from its Xenopus orthologue, XER81, whose expression is more reminiscent of the FGF dependant zebrafish PEA3 family members. In keeping with this observation, while pea3, erm and XER81 require FGF activity for their expression, er81 does not require FGF signalling. Our results suggest that, since the vertebrate specific expansion of the PEA3 subfamily of Ets transcription factors, the regulation of PEA3 genes has been independently modified during the evolution of different vertebrate lineages.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping