PUBLICATION

Divergence in regulation of the PEA3 family of ETS transcription factors

Authors
Roussigne, M., and Blader, P.
ID
ZDB-PUB-060315-1
Date
2006
Source
Gene expression patterns : GEP   6(8): 777-782 (Journal)
Registered Authors
Blader, Patrick, Roussigné, Myriam
Keywords
Zebrafish, PEA3 family, er81, FGF, Evolution
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Cloning, Molecular
  • Embryo, Nonmammalian
  • Fibroblast Growth Factors/metabolism
  • Gene Expression Regulation, Developmental
  • Molecular Sequence Data
  • Phylogeny
  • Proto-Oncogene Proteins c-ets/genetics
  • Proto-Oncogene Proteins c-ets/metabolism*
  • Sequence Homology, Amino Acid
  • Transcription Factors/metabolism*
  • Zebrafish/embryology
  • Zebrafish/genetics*
  • Zebrafish/metabolism*
  • Zebrafish Proteins/genetics
PubMed
16516559 Full text @ Gene Expr. Patterns
Abstract
Here, we report the cloning of a cDNA encoding zebrafish ER81, a member of the PEA3 family of Ets transcription factors. Strikingly, the spatial and temporal expression of er81 is significantly different from its Xenopus orthologue, XER81, whose expression is more reminiscent of the FGF dependant zebrafish PEA3 family members. In keeping with this observation, while pea3, erm and XER81 require FGF activity for their expression, er81 does not require FGF signalling. Our results suggest that, since the vertebrate specific expansion of the PEA3 subfamily of Ets transcription factors, the regulation of PEA3 genes has been independently modified during the evolution of different vertebrate lineages.
Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes