ZFIN ID: ZDB-PUB-060213-3
Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish
Panagos, P.G., Dobrinski, K.P., Chen, X., Grant, A.W., Traver, D., Djeu, J.Y., Wei, S., and Yoder, J.A.
Date: 2006
Source: Immunogenetics   58(1): 31-40 (Journal)
Registered Authors: Dobrinski, Kim P., Grant, Amanda W., Traver, David, Yoder, Jeffrey A.
Keywords: C-type lectin, ITIM, Natural killer cells, Signaling motifs
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Cell Survival/physiology
  • Chromosomes*
  • Chromosomes, Artificial, Bacterial
  • Killer Cells, Natural/metabolism
  • Lectins, C-Type/chemistry
  • Lectins, C-Type/genetics*
  • Lectins, C-Type/metabolism
  • Lectins, C-Type/physiology
  • Lymphocytes/metabolism*
  • Models, Molecular
  • Molecular Sequence Data
  • Myeloid Cells/metabolism*
  • Phylogeny
  • Zebrafish/genetics*
  • Zebrafish/immunology
  • Zebrafish/metabolism
  • Zebrafish Proteins/genetics*
  • Zebrafish Proteins/metabolism*
PubMed: 16467987 Full text @ Immunogenetics
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ABSTRACT
The identification of C-type lectin (Group V) natural killer (NK) cell receptors in bony fish has remained elusive. Analyses of the Fugu rubripes genome database failed to identify Group V C-type lectin domains (Zelensky and Gready, BMC Genomics 5:51, 2004) suggesting that bony fish, in general, may lack such receptors. Numerous Group II C-type lectin receptors, which are structurally similar to Group V (NK) receptors, have been characterized in bony fish. By searching the zebrafish genome database we have identified a multi-gene family of Group II immune-related, lectin-like receptors (illrs) whose members possess inhibiting and/or activating signaling motifs typical of Group V NK receptors. Illr genes are differentially expressed in the myeloid and lymphoid lineages, suggesting that they may play important roles in the immune functions of multiple hematopoietic cell lineages.
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