ZFIN ID: ZDB-PUB-050518-11
Ray-Fin Fish Tetraploidization Gave Rise to Pufferfish Duplicates of NPY and PYY, but Zebrafish NPY Duplicate Was Lost
Sundström, G., Larsson, T.A., Brenner, S., Venkatesh, B., and Larhammar, D.
Date: 2005
Source: Annals of the New York Academy of Sciences   1040: 476-478 (Journal)
Registered Authors: Larhammar, Dan, Larsson, Tomas A., Sundström, Görel, Venkatesh, Byrappa
Keywords: NPY; PYY; PY; pufferfish; fugu; zebrafish; duplication; peptide
MeSH Terms:
  • Animals
  • Genes, Duplicate/genetics*
  • Humans
  • Neuropeptide Y/genetics*
  • Peptide YY/genetics*
  • Polyploidy
  • Species Specificity
  • Takifugu/genetics*
  • Zebrafish/genetics*
PubMed: 15891094 Full text @ Ann N Y Acad Sci
We have used sequence information and gene location to identify NPY family genes in the pufferfish, Takifugu rubripes (fugu), and zebrafish. Fugu has two copies of NPY, presumably resulting from the ray-fin fish tetraploidization. Zebrafish has probably lost one of the copies. Both species have two copies of PYY, the second of which was previously named PY. The two fugu NPY genes are predominantly expressed in brain. The two PYY genes are expressed in a broad range of tissues including brain and gonads. Thus, the NPY system appears to be more complex in teleosts than in tetrapods.