ZFIN ID: ZDB-PERS-960805-319
Larhammar, Dan
Email: dan.larhammar@neuro.uu.se
URL: http://www.neuro.uu.se/research/research-groups/dan-larhammar/
Affiliation: Larhammar Lab
Address: Department of Neuroscience Unit of Pharmacology Uppsala University Box 593 Uppsala, SE-75124 Sweden
Country: Sweden
Phone: 46-18-4714173
ORCID ID: 0000-0002-6736-0663

Professor of molecular cell biology at Uppsala University since 1994.
For CV and complete list of publications, see http://www.anst.uu.se/dla05000/

Research interests:
- Evolution of vertebrate genes involved in learning and long-term memory, with special focus on zebrafish.
- Evolution of vertebrate genes involved in vision, with special focus on zebrafish.
- Evolution of gene families in vertebrates, particularly neuronal and endocrine gene families such as peptide genes, receptor genes, ion channels, etc.

Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
Landin, J., Hovey, D., Xu, B., Lagman, D., Zettergren, A., Larhammar, D., Kettunen, P., Westberg, L. (2020) Oxytocin Receptors Regulate Social Preference in Zebrafish. Scientific Reports. 10:5435
Abalo, X.M., Lagman, D., Heras, G., Del Pozo, A., Eggert, J., Larhammar, D. (2019) Circadian regulation of phosphodiesterase 6 genes in zebrafish differs between cones and rods: Implications for photopic and scotopic vision. Vision Research. 166:43-51
Pedersen, J.E., Bergqvist, C.A., Larhammar, D. (2019) Evolution of vertebrate nicotinic acetylcholine receptors. BMC Evolutionary Biology. 19:38
Pedersen, J.E., Bergqvist, C.A., Larhammar, D. (2018) Evolution of the Muscarinic Acetylcholine Receptors in Vertebrates. eNeuro. 5(5):
Cardoso, J.C., Bergqvist, C.A., Felix, R.C., Larhammar, D. (2016) Corticotropin-releasing hormone family evolution: five ancestral genes remain in some lineages. Journal of molecular endocrinology. 57(1):73-86
Lagman, D., Franzén, I.E., Eggert, J., Larhammar, D., Abalo, X.M. (2016) Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity. BMC Evolutionary Biology. 16:124
Lagman, D., Callado-Pérez, A., Franzén, I.E., Larhammar, D., Abalo, X.M. (2015) Transducin Duplicates in the Zebrafish Retina and Pineal Complex: Differential Specialisation after the Teleost Tetraploidisation. PLoS One. 10:e0121330
Larhammar, D., Xu, B., and Bergqvist, C.A. (2014) Unexpected multiplicity of QRFP receptors in early vertebrate evolution. Frontiers in neuroscience. 8:337
Lagman, D., Ocampo Daza, D., Widmark, J., Abalo, X.M., Sundström, G., and Larhammar, D. (2013) The vertebrate ancestral repertoire of visual opsins, transducin alpha subunits and oxytocin/vasopressin receptors was established by duplication of their shared genomic region in the two rounds of early vertebrate genome duplications. BMC Evolutionary Biology. 13:238
Sundström, G., Larsson, T.A., Xu, B., Heldin, J., and Larhammar, D. (2013) Interactions of zebrafish peptide YYb with the neuropeptide Y-family receptors Y4, Y7, Y8a, and Y8b. Frontiers in neuroscience. 7:29
Larhammar, D., and Bergqvist, C.A. (2013) Ancient Grandeur of the Vertebrate Neuropeptide Y System Shown by the Coelacanth Latimeria chalumnae. Frontiers in neuroscience. 7:27
Lagman, D., Sundström, G., Daza, D.O., Abalo, X.M., and Larhammar, D. (2012) Expansion of transducin subunit gene families in early vertebrate tetraploidizations. Genomics. 100(4):203-211
Daza, D.O., Lewicka, M., and Larhammar, D. (2012) The oxytocin/vasopressin receptor family has at least five members in the gnathostome lineage, inclucing two distinct V2 subtypes. General and comparative endocrinology. 175(1):135-143
Hultqvist, G., Daza, D.O., Larhammar, D., and Kilimann, M.W. (2012) Evolution of the vertebrate paralemmin gene family: ancient origin of gene duplicates suggests distinct functions. PLoS One. 7(7):e41850
Fällmar, H., Sundström, G., Lundell, I., Mohell, N., and Larhammar, D. (2011) Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 160(4):166-73
Daza, D.O., Sundström, G., Bergqvist, C.A., Duan, C., and Larhammar, D. (2011) Evolution of the insulin-like growth factor binding protein (IGFBP) family. Endocrinology. 152(6):2278-2289
Sundström, G., Dreborg, S., and Larhammar, D. (2010) Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. PLoS One. 5(5):e10512
Ocampo Daza, D., Sundström, G., Larsson, T.A., and Larhammar, D. (2009) Evolution of the growth hormone-prolactin-somatolactin system in relation to vertebrate tetraploidizations. Annals of the New York Academy of Sciences. 1163:491-493
Larsson, T.A., Tay, B.H., Sundström, G., Fredriksson, R., Brenner, S., Larhammar, D., and Venkatesh, B. (2009) Neuropeptide Y-family peptides and receptors in the elephant shark, Callorhinchus milii confirm gene duplications before the gnathostome radiation. Genomics. 93(3):254-260
Dreborg, S., Sundström, G., Larsson, T.A., and Larhammar, D. (2008) Evolution of vertebrate opioid receptors. Proceedings of the National Academy of Sciences of the United States of America. 105(40):15487-15492
Sundstrom, G., Larsson, T.A., and Larhammar, D. (2008) Phylogenetic and chromosomal analyses of multiple gene families syntenic with vertebrate Hox clusters. BMC Evolutionary Biology. 8(1):254
Salaneck, E., Larsson, T.A., Larson, E.T., and Larhammar, D. (2008) Birth and death of neuropeptide Y receptor genes in relation to the teleost fish tetraploidization. Gene. 409(1-2):61-71
Sundström, G., Larsson, T.A., Brenner, S., Venkatesh, B., and Larhammar, D. (2008) Evolution of the neuropeptide Y family: New genes by chromosome duplications in early vertebrates and in teleost fishes. General and comparative endocrinology. 155(3):705-716
Larsson, T.A., Larson, E.T., Fredriksson, R., Conlon, J.M., and Larhammar, D. (2006) Characterization of NPY receptor subtypes Y2 and Y7 in rainbow trout Oncorhynchus mykiss. Peptides. 27(6):1320-1327
Bromee, T., Venkatesh, B., Brenner, S., Postlethwait, J.H., Yan, Y.L., and Larhammar, D. (2006) Uneven evolutionary rates of bradykinin B1 and B2 receptors in vertebrate lineages. Gene. 373:100-108
Fredriksson, R., Sjodin, P., Larson, E.T., Conlon, J.M., and Larhammar, D. (2006) Cloning and characterization of a zebrafish Y2 receptor. Regulatory peptides. 133(1-3):32-40
Conlon, J.M., and Larhammar, D. (2005) The evolution of neuroendocrine peptides. General and comparative endocrinology. 142(1-2):53-9
Mathieu, M., Trombino, S., Argenton, F., Larhammar, D., and Vallarino, M. (2005) Developmental Expression of NPY/PYY Receptors zYb and zYc in Zebrafish. Annals of the New York Academy of Sciences. 1040:399-401
Bromée, T., Conlon, J.M., and Larhammar, D. (2005) Bradykinin Receptors in the Zebrafish (Danio rerio). Annals of the New York Academy of Sciences. 1040:246-248
Larsson, T.A., Olsson, F., Sundström, G., Brenner, S., Venkatesh, B., and Larhammar, D. (2005) Pufferfish and Zebrafish Have Five Distinct NPY Receptor Subtypes, but Have Lost Appetite Receptors Y1 and Y5. Annals of the New York Academy of Sciences. 1040:375-377
Salaneck, E., Larson, E.T., Larsson, T.A., and Larhammar, D. (2005) Effects of a teleost tetraploidization on neuropeptide y receptor gene repertoire in ray-finned fishes. Annals of the New York Academy of Sciences. 1040:457-459
Sundström, G., Larsson, T.A., Brenner, S., Venkatesh, B., and Larhammar, D. (2005) Ray-Fin Fish Tetraploidization Gave Rise to Pufferfish Duplicates of NPY and PYY, but Zebrafish NPY Duplicate Was Lost. Annals of the New York Academy of Sciences. 1040:476-478
Bromee, T., Kukkonen, J.P., Andersson, P., Conlon, J.M., and Larhammar, D. (2005) Pharmacological characterization of ligand-receptor interactions at the zebrafish bradykinin receptor. British journal of pharmacology. 144(1):11-16
Larhammar, D., and Salaneck, E. (2004) Molecular evolution of NPY receptor subtypes. Neuropeptides. 38(4):141-151
Ruuskanen, J., Xhaard, H., Marjamäki, A., Salaneck, E., Salminen, T., Yan, Y.-L., Postlethwait, J.H., Johnson, M.S., Larhammar, D., and Scheinin, M. (2004) Identification of duplicated fourth {alpha}2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish. Mol. Biol. Evol.. 10:14-28
Fredriksson, R., Larson E.T., Yan, Y.-L., Postlethwait, J.H., and Larhammar, D. (2004) Novel neuropeptide Y Y2-like receptor subtype in zebrafish and frogs supports early vertebrate chromosome duplications. Journal of molecular evolution. 58(1):106-114
Larson, E.T., Fredriksson, R., Johansson, S.R.T., and Larhammar, D. (2003) Cloning, pharmacology, and distribution of the neuropeptide Y-receptor Yb in rainbow trout. Peptides. 24(3):385-395
Ringholm, A., Fredriksson, R., Poliakova, N., Yan, Y.-L., Postlethwait, J.H., Larhammar, D., and Schiöth, H.B. (2002) One melanocortin 4 and two melanocortin 5 receptors from zebrafish show remarkable conservation in structure and pharmacology. Journal of neurochemistry. 82(1):6-18
Dunér, T., Conlon, J.M., Kukkonen, J.P., Akerman, K.E.O., Yan, Y.-L., Postlethwait, J.H., and Larhammar, D. (2002) Cloning, structural characterization and functional expression of a zebrafish bradykinin B2-related receptor. The Biochemical journal. 364(3):817-824
Salaneck, E., Fredriksson, R., Larson, E.T., Conlon, J.M., and Larhammar, D. (2001) A neuropeptide Y receptor Y1-subfamily gene from an agnathan, the European river lamprey. European journal of biochemistry. 268(23):6146-6154
Berglund, M.M., Lundell, I., Cabrele, C., Serradeil-Le Gal, C., Beck-Sickinger, A.G., and Larhammar, D. (2000) Binding properties of three neuropeptide Y receptor subtypes from zebrafish: comparison with mammalian Y1 receptors. Biochemical pharmacology. 60(12):1815-1822
Söderberg, C., Wraith, A., Ringvall, M., Yan, Y.-L., Postlethwait, J.H., Brodin, L., and Larhammar, D. (2000) Zebrafish genes for neuropeptide Y and peptide YY reveal origin by chromosome duplication from an ancestral gene linked to the homeobox cluster. Journal of neurochemistry. 75(3):908-918
Sharma, P., Arvidsson, A.K., Wraith, A., Beck-Sickinger, A.G., Jönsson-Rylander, A.C., Larhammar, D. (1999) Characterization of the cloned Atlantic cod neuropeptide Y-Yb receptor: peptide-binding requirements distinct from known mammalian Y receptors. General and comparative endocrinology. 115(3):422-428
Starbäck, P., Lundell, I., Fredriksson, R., Berglund, M.M., Yan, Y.-L., Wraith, A., Söderberg, C., Postlethwait, J.H., and Larhammar, D. (1999) Neuropeptide Y receptor subtype with unique properties cloned in the zebrafish: the zYa receptor. Mol. Brain Res.. 70(2):242-252
Risinger, C., Salaneck, E., Söderberg, C., Gates, M., Postlethwait, J.H., and Larhammar, D. (1998) Cloning of two loci for synapse protein Snap25 in zebrafish: Comparison of paralogous linkage groups suggests loss of one locus in the mammalian lineage. Journal of neuroscience research. 54(5):563-573
Arvidsson, A.K., Wraith, A., Jonsson-Rylander, A.C., and Larhammar, D. (1998) Cloning of a neuropeptide Y/peptide YY receptor from the Atlantic cod: the Yb receptor. Regulatory peptides. 76:39-43
Postlethwait, J.H, Yan, Y.-L., Gates, M.A., Horne, S., Amores, A., Brownlie, A., Donovan, A., Egan, E.S., Force, A., Gong, Z., Goutel, C., Fritz, A., Kelsh, R., Knapik, E., Liao, E., Paw, B., Ransom, D., Singer, A., Thomson, M., Abduljabbar, T.S., Yelick, P., Beier, D., Joly, J.-S., Larhammar, D., Rosa, F., Westerfield, M., Zon, L.I., Johnson, S.L., and Talbot, W.S. (1998) Vertebrate genome evolution and the zebrafish gene map. Nature Genetics. 18:345-349
Lundell, I., Ringvall, M., Starbäck, P., Salaneck, E., Berglund, M., and Larhammar, D. (1998) Cloning of neuropeptide Y receptors in zebrafish. Annals of the New York Academy of Sciences. 839:515-517
Ringvall, M., Berglund, M.M., and Larhammar, D. (1997) Multiplicity of neruopeptide Y receptors: cloning of a third distinct subtype in the zebrafish. Biochemical and Biophysical Research Communications. 241:749-755
Lundell, I., Berglund, M.M., Starbäck, P., Salaneck, E., Gehlert, D.R., and Larhammar, D. (1997) Cloning and characterization of a novel neuropeptide Y receptor subtype in the zebrafish. DNA and cell biology. 16(11):1357-1363
Larhammar, D., Berglund, M.M., and Lundell, I. (1997) Multiplicity of NPY receptors - an evolutionary perspective. Regulatory peptides. 71:209

Differential evolution of voltage-gated sodium channels in tetrapods and teleost fishes
Jenny Widmark; Gorel Sundstrom; Daniel Ocampo Daza; Dan Larhammar
Molecular Biology and Evolution 2010; doi: 10.1093/molbev/msq257

Cerdá-Reverter, J. M., Martínez-Rodríguez, G., Zanuy, S., Carrillo, M., and Larhammar, D. Molecular evolution of the neuropeptide Y (NPY) family of peptides: cloning of NPY-related peptides from the sea bass (Dicentrarchus labrax). Regul. Peptides 95, 25-34 (2000).

The emphasis of the following article is on teleost peptides:

Cerdá-Reverter J. M. and Larhammar, D. Neuropeptide Y family of peptides: structure, anatomical expression, function, and molecular evolution. Biochem. Cell Biol. 78, 371-392 (2000).