Enhancer sequence conservation between vertebrates is favoured in developmental regulator genes
- Plessy, C., Dickmeis, T., Chalmel, F., and Strähle, U.
- Trends in genetics : TIG 21(4): 207-210 (Journal)
- Registered Authors
- Dickmeis, Thomas, Plessy, Charles, Strähle, Uwe
- MeSH Terms
- Databases, Nucleic Acid*
- Enhancer Elements, Genetic*
- Genes, Regulator/genetics*
- 15797614 Full text @ Trends Genet.
Plessy, C., Dickmeis, T., Chalmel, F., and Strähle, U. (2005) Enhancer sequence conservation between vertebrates is favoured in developmental regulator genes. Trends in genetics : TIG. 21(4):207-210.
Sequence conservation has been used to find genes and to pinpoint functional non-coding sequences such as transcriptional regulatory elements. In this article, we analysed the conservation of 104 experimentally validated murine enhancer sequences between the mouse and zebrafish genomes. Surprisingly, only 10.5% of the mouse enhancers have homologues in zebrafish. All of the genes with conserved cis-elements have regulatory functions during embryonic development, perhaps reflecting substantial structural constraints on the integration of spatio-temporal signalling cues during the formation of the vertebrate body.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes