|ZFIN ID: ZDB-PUB-050404-7|
Enhancer sequence conservation between vertebrates is favoured in developmental regulator genes
Plessy, C., Dickmeis, T., Chalmel, F., and Strähle, U.
|Source:||Trends in genetics : TIG 21(4): 207-210 (Journal)|
|Registered Authors:||Dickmeis, Thomas, Plessy, Charles, Strähle, Uwe|
|PubMed:||15797614 Full text @ Trends Genet.|
Plessy, C., Dickmeis, T., Chalmel, F., and Strähle, U. (2005) Enhancer sequence conservation between vertebrates is favoured in developmental regulator genes. Trends in genetics : TIG. 21(4):207-210.
ABSTRACTSequence conservation has been used to find genes and to pinpoint functional non-coding sequences such as transcriptional regulatory elements. In this article, we analysed the conservation of 104 experimentally validated murine enhancer sequences between the mouse and zebrafish genomes. Surprisingly, only 10.5% of the mouse enhancers have homologues in zebrafish. All of the genes with conserved cis-elements have regulatory functions during embryonic development, perhaps reflecting substantial structural constraints on the integration of spatio-temporal signalling cues during the formation of the vertebrate body.
- Genes / Markers (7)