ZFIN ID: ZDB-PUB-050404-7
Enhancer sequence conservation between vertebrates is favoured in developmental regulator genes
Plessy, C., Dickmeis, T., Chalmel, F., and Strähle, U.
Sequence conservation has been used to find genes and to pinpoint functional non-coding sequences such as transcriptional regulatory elements. In this article, we analysed the conservation of 104 experimentally validated murine enhancer sequences between the mouse and zebrafish genomes. Surprisingly, only 10.5% of the mouse enhancers have homologues in zebrafish. All of the genes with conserved cis-elements have regulatory functions during embryonic development, perhaps reflecting substantial structural constraints on the integration of spatio-temporal signalling cues during the formation of the vertebrate body.