ZFIN ID: ZDB-PUB-050404-7
Enhancer sequence conservation between vertebrates is favoured in developmental regulator genes
Plessy, C., Dickmeis, T., Chalmel, F., and Strähle, U.
Date: 2005
Source: Trends in genetics : TIG 21(4): 207-210 (Journal)
Registered Authors: Dickmeis, Thomas, Plessy, Charles, Strähle, Uwe
Keywords: none
MeSH Terms: Animals; Databases, Nucleic Acid*; Enhancer Elements, Genetic*; Genes, Regulator/genetics*; Humans; Mice; Zebrafish/genetics*
PubMed: 15797614 Full text @ Trends Genet.
ABSTRACT
Sequence conservation has been used to find genes and to pinpoint functional non-coding sequences such as transcriptional regulatory elements. In this article, we analysed the conservation of 104 experimentally validated murine enhancer sequences between the mouse and zebrafish genomes. Surprisingly, only 10.5% of the mouse enhancers have homologues in zebrafish. All of the genes with conserved cis-elements have regulatory functions during embryonic development, perhaps reflecting substantial structural constraints on the integration of spatio-temporal signalling cues during the formation of the vertebrate body.
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