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ZFIN ID: ZDB-PUB-050127-4
The zebrafish as a model of heart regeneration
Raya, A., Consiglio, A., Kawakami, Y., Rodriguez-Esteban, C., and Izpisúa Belmonte, J.C.
Date: 2004
Source: Cloning and stem cells   6(4): 345-351 (Review)
Registered Authors: Izpisúa Belmonte, Juan Carlos, Kawakami, Yasuhiko, Raya, Angel, Rodriguez-Esteban, Concepcion
Keywords: none
MeSH Terms:
  • Animals
  • Heart/physiology*
  • Models, Animal*
  • Regeneration/physiology*
  • Zebrafish/physiology*
PubMed: 15671662 Full text @ Cloning Stem Cells
Regeneration is a complex biological process by which animals can restore the shape, structure and function of body parts lost after injury, or after experimental amputation. Only a few species of vertebrates display the capacity to regenerate body parts during adulthood. In the case of the heart, newts display a remarkable ability to regenerate large portions of myocardium after amputation, although the mechanisms underlying this process have not been addressed. Recently, it has been shown that adult zebrafish can also regenerate their hearts, thus offering new possibilities for experimentally approaching this fascinating biological phenomenon. The first insights into heart regeneration gained by studying this model organism are reviewed here.