ZFIN ID: ZDB-PUB-030908-7
When Wnts antagonize Wnts
Weidinger, G. and Moon, R.T.
Date: 2003
Source: The Journal of cell biology   162(5): 753-756 (Review)
Registered Authors: Moon, Randall T., Weidinger, Gilbert
Keywords: none
MeSH Terms:
  • Animals
  • Cytoskeletal Proteins/metabolism
  • Mice
  • Morphogenesis/physiology
  • Proto-Oncogene Proteins/genetics
  • Proto-Oncogene Proteins/metabolism*
  • Signal Transduction/physiology*
  • Trans-Activators/metabolism
  • Wnt Proteins
  • Zebrafish/embryology
  • Zebrafish Proteins*
  • beta Catenin
PubMed: 12952929 Full text @ J. Cell Biol.
Secreted Wnt ligands appear to activate a variety of signaling pathways. Two papers in this issue now present genetic evidence that "noncanonical" Wnt signaling inhibits the "canonical" Wnt/beta-catenin pathway. Westfall et al. (2003a) show that zebrafish embryos lacking maternal Wnt-5 function are dorsalized due to ectopic activation of beta-catenin, whereas Topol et al. (2003) report that chondrogenesis in the distal mouse limb bud depends on inhibition of Wnt/beta-catenin signaling by a paralogue of Wnt-5. These studies present the first genetic confirmation of the previous hypothesis that vertebrate Wnt signaling pathways can act in an antagonistic manner.