|ZFIN ID: ZDB-PUB-030715-6|
NompC TRP channel required for vertebrate sensory hair cell mechanotransduction
Sidi, S., Friedrich, R.W., and Nicolson, T.
|Source:||Science (New York, N.Y.) 301(5629): 96-99 (Journal)|
|Registered Authors:||Friedrich, Rainer, Nicolson, Teresa, Sidi, Samuel|
|PubMed:||12805553 Full text @ Science|
Sidi, S., Friedrich, R.W., and Nicolson, T. (2003) NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. Science (New York, N.Y.). 301(5629):96-99.
ABSTRACTThe senses of hearing and balance in vertebrates rely on the sensory hair cells (HCs) of the inner ear. The central element of the HC's transduction apparatus is a mechanically gated ion channel of unknown identity. Here we report that the zebrafish ortholog of Drosophila no mechanoreceptor potential C (nompC), which encodes a transient receptor potential (TRP) channel, is critical for HC mechanotransduction. In zebrafish larvae, nompC is selectively expressed in sensory HCs. Morpholino-mediated removal of nompC function eliminated transduction-dependent endocytosis and electrical responses in HCs, resulting in larval deafness and imbalance. These observations indicate that nompC encodes a vertebrate HC mechanotransduction channel.