ZFIN ID: ZDB-PUB-030116-2
Zebrafish gastrulation movements: bridging cell and developmental biology
Heisenberg, C.-P. and Tada, M.
Date: 2002
Source: Seminars in cell & developmental biology   13(6): 471-479 (Review)
Registered Authors: Heisenberg, Carl-Philipp, Tada, Masazumi
Keywords: gastrulation; convergent extension; cell polarity; zebrafish
MeSH Terms:
  • Animals
  • Cell Movement/genetics
  • Embryonic and Fetal Development/genetics*
  • Gastrula/cytology*
  • Mutation
  • Signal Transduction
  • Zebrafish/embryology*
  • Zebrafish/genetics
PubMed: 12468250 Full text @ Sem. Cell Dev. Biol.
During vertebrate gastrulation, large cellular rearrangements lead to the formation of the three germ layers, ectoderm, mesoderm and endoderm. Zebrafish offer many genetic and experimental advantages for studying vertebrate gastrulation movements. For instance, several mutants, including silberblick, knypek and trilobite, exhibit defects in morphogenesis during gastrulation. The identification of the genes mutated in these lines together with the analysis of the mutant phenotypes has provided new insights into the molecular and cellular mechanisms that underlie vertebrate gastrulation movements.