ZFIN ID: ZDB-PUB-020807-4
Non-canonical Wnt signalling and regulation of gastrulation movements
Tada, M., Concha, M.I., and Heisenberg, C.-P.
Date: 2002
Source: Seminars in cell & developmental biology   13(3): 251-260 (Review)
Registered Authors: Concha, Miguel, Heisenberg, Carl-Philipp, Tada, Masazumi
Keywords: none
MeSH Terms:
  • Animals
  • Calcium/metabolism
  • Gastrula/physiology*
  • Glycoproteins/metabolism
  • Ligands
  • Models, Biological
  • Mutation
  • Phenotype
  • Proto-Oncogene Proteins/metabolism*
  • Signal Transduction*
  • Wnt Proteins
  • Xenopus/embryology*
  • Xenopus Proteins
  • Zebrafish/embryology*
  • Zebrafish Proteins*
PubMed: 12137734 Full text @ Sem. Cell Dev. Biol.
Members of the Wnt family have been implicated in a variety of developmental processes including axis formation, patterning of the central nervous system and tissue morphogenesis. Recent studies have shown that a Wnt signalling pathway similar to that involved in the establishment of planar cell polarity in Drosophila regulates convergent extension movements during zebrafish and Xenopus gastrulation. This finding provides a good starting point to dissect the complex cell biology and genetic regulation of vertebrate gastrulation movements.