Non-canonical Wnt signalling and regulation of gastrulation movements
- Tada, M., Concha, M.I., and Heisenberg, C.-P.
- Seminars in cell & developmental biology 13(3): 251-260 (Review)
- Registered Authors
- Concha, Miguel, Heisenberg, Carl-Philipp, Tada, Masazumi
- MeSH Terms
- Models, Biological
- Proto-Oncogene Proteins/metabolism*
- Signal Transduction*
- Wnt Proteins
- Xenopus Proteins
- Zebrafish Proteins*
- 12137734 Full text @ Sem. Cell Dev. Biol.
Tada, M., Concha, M.I., and Heisenberg, C.-P. (2002) Non-canonical Wnt signalling and regulation of gastrulation movements. Seminars in cell & developmental biology. 13(3):251-260.
Members of the Wnt family have been implicated in a variety of developmental processes including axis formation, patterning of the central nervous system and tissue morphogenesis. Recent studies have shown that a Wnt signalling pathway similar to that involved in the establishment of planar cell polarity in Drosophila regulates convergent extension movements during zebrafish and Xenopus gastrulation. This finding provides a good starting point to dissect the complex cell biology and genetic regulation of vertebrate gastrulation movements.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes