Zebrafish myelopoiesis and blood cell development
- Hsu, K., Kanki, J.P., and Look, A.T.
- Current opinion in hematology 8(4): 245-251 (Review)
- Registered Authors
- Hsu, Karl, Kanki, John, Look, A. Thomas
- MeSH Terms
- Animals, Genetically Modified
- Antisense Elements (Genetics)
- Gene Expression Regulation, Developmental
- Hematologic Diseases/etiology
- Mutagenesis, Insertional
- Myeloid Progenitor Cells/physiology*
- Zebrafish/growth & development*
- 11561163 Full text @ Curr. Opin. Hematol.
Hsu, K., Kanki, J.P., and Look, A.T. (2001) Zebrafish myelopoiesis and blood cell development. Current opinion in hematology. 8(4):245-251.
The zebrafish (Danio rerio) animal model offers a unique opportunity to discover novel genes required for the control of normal vertebrate myeloid cell development. It is well suited for both developmental and genetic analyses: eg, genome-wide chemical mutagenesis screens have led to the identification of specific new genes affecting vertebrate erythropoiesis. Mutants defective in one or more hematopoietic functions will be useful as models of human disease and will assist in the elucidation of lineage-specific developmental programs. By using a combination of forward genetic mutagenesis screens and emerging strategies based on transgenic and antisense knockdown approaches, it should be possible to dissect the genetic programs that lead to myeloproliferative/myelodysplastic syndromes and to acute myeloid leukemia.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes