BIOGRAPHY AND RESEARCH INTERESTS
ZFIN ID: ZDB-PERS-980303-20
We are interested in the development of the thyroid in the vertebrate embryo. The thyroid is an endocrine gland present in vertebrates from fish to human, secreting one hormone, thyroxin. Thyroxin is required during development (neuronal specification, metamorphosis etc.), and as a major regulator of metabolism in the adult organism.
We use zebrafish as a model organism in order to identify genes involved in thyroid development. We are currently rescreening available mutants for thyroid defects. Preliminary data reveal new factors involved in induction and differentiation processes of the thyroid tissue.
Short CV of Klaus Rohr:
Since 2001: Junior group leader/Emmy-Noether fellow (thyroid group) at the Institute of Developmental Biology in Cologne, Germany.
1998-2001: Postdoctoral fellowship at the Deptartment of Anatomy and Developmental Biology, University College London, United Kingdom (Steve Wilson/Nigel Holder groups).
1996-1998: Ph.D. thesis at the Zoological Institut of the LMU, Munich, Germany: Expression and regulation of an odd-paired- like gene in zebrafish (supervisor: Professor Diethard Tautz).
1995: 'Diploma' (comparable to masters) in Biology.
1995: Diploma thesis: Analysis of segmentation gene expression in the primitive midge Clogmia albipunctata (supervisor: Professor Klaus Sander, University of Freiburg).
1992-1995: Continuing study of Biology at the University of Freiburg, Germany.
1991-1992: Study of Biology at the University of Mainz, Germany.
Wendl, T., Adzic, D., Schoenebeck, J.J., Scholpp, S., Brand, M., Yelon, D., and Rohr, K.B. (2007) Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals. Development (Cambridge, England). 134(15):2871-2879
To, T.T., Hahner, S., Nica, G., Rohr, K.B., Hammerschmidt, M., Winkler, C., and Allolio, B. (2007) Pituitary-interrenal interaction in zebrafish interrenal organ development. Molecular endocrinology (Baltimore, Md.). 21(2):472-485
Alt, B., Elsalini, O.A., Schrumpf, P., Haufs, N., Lawson, N.D., Schwabe, G.C., Mundlos, S., Gruters, A., Krude, H., and Rohr, K.B. (2006) Arteries define the position of the thyroid gland during its developmental relocalisation. Development (Cambridge, England). 133(19):3797-3804
Alt, B., Reibe, S., Feitosa, N.M., Elsalini, O.A., Wendl, T., and Rohr, K.B. (2006) Analysis of origin and growth of the thyroid gland in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 235(7):1872-1883
Gajewski, M., Sieger, D., Alt, B., Leve, C., Hans, S., Wolff, C., Rohr, K.B., and Tautz, D. (2003) Anterior and posterior waves of cyclic her1 gene expression are differentially regulated in the presomitic mesoderm of zebrafish. Development (Cambridge, England). 130(18):4269-4278
Wendl, T., Lun, K., Mione, M., Favor, J., Brand, M., Wilson, S.W., and Rohr, K.B. (2002) pax2.1 is required for the development of thyroid follicles in zebrafish. Development (Cambridge, England). 129(15):3751-3760
Barth, K.A., Kishimoto, Y., Rohr, K.B., Seydler, C., Schulte-Merker, S., and Wilson, S.W. (1999) Bmp activity establishes a gradient of positional information throughout the entire neural plate. Development (Cambridge, England). 126(22):4977-4987
Kluge, B.; Renault, N.; Rohr, K.B. (2005): Anatomical and molecular reinvestigation of lamprey endostyle development provides new insight into thyroid gland evolution. Dev Genes Evol 215(1): 32-40
Klaus B. Rohr, Diethard Tautz and Klaus Sander (1999): Segmentation gene expression in the mothmidge Clogmia albipunctata (Diptera, Psychodidae) and other primitive dipterans. Dev Gene Evol 209(3): 145-154