PUBLICATION
The EGF-CFC gene family in vertebrate development
- Authors
- Shen, M.M. and Schier, A.F.
- ID
- ZDB-PUB-000622-4
- Date
- 2000
- Source
- Trends in genetics : TIG 16(7): 303-309 (Review)
- Registered Authors
- Schier, Alexander
- Keywords
- none
- MeSH Terms
-
- Intercellular Signaling Peptides and Proteins*
- Animals
- Vertebrates/embryology*
- Molecular Sequence Data
- Multigene Family*
- Sequence Homology, Amino Acid
- Growth Substances/chemistry
- Growth Substances/genetics*
- Growth Substances/metabolism
- Amino Acid Sequence
- Humans
- Gene Expression Regulation, Developmental*
- PubMed
- 10858660 Full text @ Trends Genet.
Citation
Shen, M.M. and Schier, A.F. (2000) The EGF-CFC gene family in vertebrate development. Trends in genetics : TIG. 16(7):303-309.
Abstract
EGF-CFC genes encode extracellular proteins that play key roles in intercellular signaling pathways during vertebrate embryogenesis. Mutations in zebrafish and mouse EGF-CFC genes lead to defects in germ-layer formation, anterior-posterior axis orientation and left-right axis specification. In addition, members of the EGF-CFC family have been implicated in carcinogenesis. Although formerly regarded as signaling molecules that are distant relatives of epidermal growth factor (EGF), recent findings indicate that EGF-CFC proteins act as essential cofactors for Nodal, a member of the transforming growth factor beta (TGF-beta) family. Here, we review molecular genetic evidence from mouse and zebrafish on biological and biochemical roles of the EGF-CFC family, and discuss differing models for EGF-CFC protein function.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping