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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-970930-11
Poon, Kar Lai
Email: klpoon@imcb.a-star.edu.sg
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Address: Institute of Molecular and Cell Biology 61 Biopolis Drive Proteos Singapore 138673
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BIOGRAPHY AND RESEARCH INTERESTS
Kar Lai Poon received her B.Sc (Hons) in Biochemistry from the National University of Singapore in 2004. Under the supervision of A/P Vladimir Korzh at the Institute of Molecular and Cell Biology in Singapore, she obtained her PhD in 2010 in which she works on the characterization of zebrafish transgenic enhancer trap (ET) lines. These ET lines GFP-tagged different anatomical components of the embryonic and adult zebrafish heart, including the epicardium and the cardiac conduction system, which enable them to be used as tools for heart development and disease studies. In addition, her work on the role of an uncharacterized RNA-binding protein rbm24a uncovered its role in sarcomere assembly and heart contractility. Her research interest lies in the understanding of the molecular development and functioning of the cardiac conduction system (CCS), which governs the rhythmic pumping of the heart.


PUBLICATIONS
Poon, K.L., Wang, X., Lee, S.G., Ng, A.S., Goh, W.H., Zhao, Z., Al-Haddawi, M., Wang, H., Mathavan, S., Ingham, P.W., Mcginnis, C., Carney, T.J. (2017) Transgenic Zebrafish Reporter Lines as Alternative in vivo Organ Toxicity Models. Toxicological sciences : an official journal of the Society of Toxicology. 156(1):133-148
Pu, Y., Hou, Z., Khin, M.M., Zamudio-Vázquez, R., Poon, K.L., Duan, H., Chan-Park, M.B. (2017) Synthesis and Antibacterial Study of Sulfobetaine/Quaternary Ammonium-Modified Star-Shaped Poly[2-(dimethylamino)ethyl methacrylate]-Based Copolymers with an Inorganic Core. Biomacromolecules. 18(1):44-55
Poon, K.L., Liebling, M., Kondrychyn, I., Brand, T., Korzh, V. (2016) Development of the cardiac conduction system in zebrafish. Gene expression patterns : GEP. 21(2):89-96
Schindler, R.F., Scotton, C., Zhang, J., Passarelli, C., Ortiz-Bonnin, B., Simrick, S., Schwerte, T., Poon, K.L., Fang, M., Rinné, S., Froese, A., Nikolaev, V.O., Grunert, C., Müller, T., Tasca, G., Sarathchandra, P., Drago, F., Dallapiccola, B., Rapezzi, C., Arbustini, E., Di Raimo, F.R., Neri, M., Selvatici, R., Gualandi, F., Fattori, F., Pietrangelo, A., Li, W., Jiang, H., Xu, X., Bertini, E., Decher, N., Wang, J., Brand, T., Ferlini, A. (2016) POPDC1S201F causes muscular dystrophy and arrhythmia by affecting protein trafficking. The Journal of Clinical Investigation. 126(1):239-53
Brand, T., Simrick, S.L., Poon, K.L., Schindler, R.F. (2014) The cAMP-binding Popdc proteins have a redundant function in the heart. Biochemical Society transactions. 42:295-301
Poon, K.L., and Brand, T. (2013) The zebrafish model system in cardiovascular research: A tiny fish with mighty prospects. Global Cardiology Science and Practice. 2013(1):9-28
Schindler, R.F., Poon, K.L., Simrick, S., and Brand, T. (2012) The Popeye domain containing genes: essential elements in heart rate control. Cardiovascular Diagnosis and Therapy. 2(4):308-319
Poon, K.L., Tan, K.T., Wei, Y.Y., Ng, C.P., Colman, A., Korzh, V., and Xu, X.Q. (2012) RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility. Cardiovascular research. 94(3):418-427
Kirchmaier, B.C., Poon, K.L., Schwerte, T., Huisken, J., Winkler, C., Jungblut, B., Stainier, D.Y., and Brand, T. (2012) The Popeye domain containing 2 (popdc2) gene in zebrafish is required for heart and skeletal muscle development. Developmental Biology. 363(2):438-450
Choudhury, D., van Noort, D., Iliescu, C., Zheng, B., Poon, K.L., Korzh, S., Korzh, V., and Yu, H. (2012) Fish and Chips: a microfluidic perfusion platform for monitoring zebrafish development. Lab on a Chip. 12(5):892-900
Teh, C., Chudakov, D.M., Poon, K.L., Mamedov, I.Z., Sek, J.Y., Shidlovsky, K., Lukyanov, S., and Korzh, V. (2010) Optogenetic in vivo cell manipulation in KillerRed-expressing zebrafish transgenics. BMC Developmental Biology. 10:110
Poon, K.L., Liebling, M., Kondrychyn, I., Garcia-Lecea, M., and Korzh, V. (2010) Zebrafish cardiac enhancer trap lines: New tools for in vivo studies of cardiovascular development and disease. Developmental dynamics : an official publication of the American Association of Anatomists. 239(3):914-926
Vasilyev, A., Liu, Y., Mudumana, S., Mangos, S., Lam, P.Y., Majumdar, A., Zhao, J., Poon, K.L., Kondrychyn, I., Korzh, V., and Drummond, I.A. (2009) Collective Cell Migration Drives Morphogenesis of the Kidney Nephron. PLoS Biology. 7(1):e9
Poon, K.L., Richardson, M., and Korzh, V. (2008) Expression of zebrafish nos2b surrounds oral cavity. Developmental dynamics : an official publication of the American Association of Anatomists. 237(6):1662-1667
Poon, K.L., Richardson, M., Lam, C.S., Khoo, H.E., and Korzh, V. (2003) Expression pattern of neuronal nitric oxide synthase in embryonic zebrafish. Gene expression patterns : GEP. 3(4):463-466

NON-ZEBRAFISH PUBLICATIONS