ZFIN ID: ZDB-PERS-960805-455
Rebagliati, Michael
Email: mrebagliati89@gmail.com
URL:
Affiliation:
Address: Through 3/2014: Institute of Genetics and Molecular and Cellular Biology (IGBMC) Pourquie Team 1 rue Laurent Fries Illkirch, France 67400
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BIOGRAPHY AND RESEARCH INTERESTS
Education/training

1977-1981, B.S. Chemistry, Stanford University
1981-1987, Ph.D. Biochemistry, Harvard Univ., Lab.of Dr.Douglas Melton
1987-1990, Damon Runyon Walter Winchell Fellow, University of Texas at Austin, Lab. of Dr. Klaus Kalthoff
1990-1993, NRC Fellow, LMG-NICHD, NIH, Lab. of Dr. Igor Dawid,
1993-1998, IRTA Fellow, LMG-NICHD, NIH, Lab. of Dr. Igor Dawid,
1999-2007, Assistant Professor, Department of Anatomy and Cell Biology, University of Iowa.
2007-2009, Research Scientist, Pourquie Lab, Stowers Institute for Medical Research.
2009-3/2014, Research Scientist, Pourquie Team, Institute of Genetics and Molecular and Cellular Biology (IGBMC)

Research Interests: Have cloned cyclops, ndr1/squint and other zebrafish nodal-related genes to look at roles of nodal-class growth factors in embryogenesis. Somites, LR patterning


PUBLICATIONS
Scott, C.A., Marsden, A.N., Rebagliati, M.R., Zhang, Q., Chamling, X., Searby, C.C., Baye, L.M., Sheffield, V.C., Slusarski, D.C. (2017) Nuclear/cytoplasmic transport defects in BBS6 underlie congenital heart disease through perturbation of a chromatin remodeling protein. PLoS Genetics. 13:e1006936
Schneider, I., Houston, D.W., Rebagliati, M.R., and Slusarski, D.C. (2008) Calcium fluxes in dorsal forerunner cells antagonize {beta}-catenin and alter left-right patterning. Development (Cambridge, England). 135(1):75-84
Gourronc, F., Ahmad, N., Nedza, N., Eggleston, T., and Rebagliati, M. (2007) Nodal activity around Kupffer's vesicle depends on the T-box transcription factors notail and spadetail and on notch signaling. Developmental dynamics : an official publication of the American Association of Anatomists. 236(8):2131-2146
Miller, V.M., Nelson, R.F., Gouvion, C.M., Williams, A., Rodriguez-Lebron, E., Harper, S.Q., Davidson, B.L., Rebagliati, M.R., and Paulson, H.L. (2005) CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(40):9152-9161
Hashimoto, H., Rebagliati, M., Ahmad, N., Muraoka, O., Kurokawa, T., Hibi, M., and Suzuki, T. (2004) The Cerberus/Dan-family protein Charon is a negative regulator of Nodal signaling during left-right patterning in zebrafish. Development (Cambridge, England). 131(8):1741-1753
Ahmad, N., Long, S., and Rebagliati, M. (2004) A Southpaw Joins the Roster: The Role of the Zebrafish nodal-related Gene Southpaw in Cardiac LR Asymmetry. Trends in cardiovascular medicine. 14(2):43-49
Horne-Badovinac, S., Rebagliati, M., and Stainier, D.Y. (2003) A cellular framework for gut-looping morphogenesis in zebrafish. Science (New York, N.Y.). 302(5645):662-665
Long, S., Ahmad, N., and Rebagliati, M. (2003) The zebrafish nodal-related gene southpaw is required for visceral and diencephalic left-right asymmetry. Development (Cambridge, England). 130(11):2303-2316
Long, S. and Rebagliati, M.R. (2002) Sensitive two-color whole-mount in situ hybridizations using digoxygenin- and dinitrophenol-labeled RNA probes. Biotechniques. 32(3):494
Aoki, T.O., Mathieu, J., Saint-Etienne, L., Rebagliati, M.R., PeyriƩras, N., and Rosa, F.M. (2002) Regulation of nodal signalling and mesendoderm formation by TARAM-A, a TGFbeta-related type I receptor. Developmental Biology. 241(2):273-288
Long, S., Ahmad, N., and Rebagliati, M. (2002) Zebrafish hearts and minds: nodal signaling in cardiac and neural left-right asymmetry. Cold Spring Harbor symposia on quantitative biology. 67:27-36
Karlen, S. and Rebagliati, M. (2001) A morpholino phenocopy of the cyclops mutation. Genesis (New York, N.Y. : 2000). 30(3):126-128
Rebagliati, M.R., Toyama, R., Haffter, P., Dawid, I.B. (1998) cyclops encodes a nodal-related factor involved in midline signaling. Proceedings of the National Academy of Sciences of the United States of America. 95:9932-9937
Rebagliati, M.R., Toyama, R., Fricke, C., Haffter, P., and Dawid, I.B. (1998) Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry. Developmental Biology. 199:261-272

NON-ZEBRAFISH PUBLICATIONS
Melton, D. A., Krieg, P. A., Rebagliati, M. R., Maniatis, T., Zinn, Kai and Green, M. R. (1984) Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Research
12, 7035-7056.

Rebagliati, M. R., Weeks, D. L., Harvey, R. P., and Melton, D. A. (1985) Identification and cloning of localized maternal RNAs from Xenopus eggs. Cell 42, 769-777.

Krieg, P. A., Rebagliati, M. R., Green, M. R., and Melton, D. A. (1985) Synthesis of hybridization probes and RNA substrates with SP6 polymerase. In Genetic Engineering, Plenum Press, New York, vol. 7: 165-184.

Weeks, D. L., Rebagliati, M. R., Harvey, R. P., and Melton, D. A. (1985) Localized maternal mRNAs in Xenopus laevis eggs. Cold Spring Harbor Symposia on QuantitativeBiology 50, 21-30.

Krieg, P. A., Rebagliati, M.R., Weeks, D.L., and Melton, D.A. (1986) Gene activation during Xenopus embryogenesis. In Gametogenesis and the Early Embryo. Proc. of the 44th Symposium of the Society for Developmental Biology. Alan R. Liss, Inc. New York, pp.357-369.

Melton, D. A. and Rebagliati, M. R. (1986) Antisense RNA injections as a test for the function of localized RNAs. In Determinative Mechanisms in Early Embryos: Symposium Meeting of the British Society for Developmental Biology, Journal of Embryology and Experimental Morphology (Supplement) 97, 211-221.

Rebagliati, M. R. and Melton, D. A. (1987) Antisense RNA injections in fertilized frog eggs reveal an RNA duplex unwinding activity. Cell 48, 599-605.

Rebagliati, M. R. (1989) An RNA Recognition Motif in the bicoid protein [letter]. Cell 58, 231-232.

Kalthoff, K. and Rebagliati, M. R. (1990) Cytoplasmic localization in insect eggs. In Cytoplasmic Organization Systems: A Primer in Developmental Biology., G. M. Malacinski (ed.), McGraw-Hill Publishing Co., New York, vol. IV, pp. 295-327.

Woolf, T. M., Jennings, C., Rebagliati, M.R., and Melton, D.A. (1990) The stability, toxicity and effectiveness of unmodified and phosphorothioate antisense oligodeoxynucleotides in Xenopus oocytes and embryos. Nucleic Acids Research 18, 1763-1769.

Dawid, I. B., Taira, M., Good, P.J. and Rebagliati, M.R. (1992) The role of growth factors in embryonic induction in Xenopus laevis. Mol. Reprod. Dev. 32: 136-144.

Dawid, I. B., Rebagliati, M. R. and Taira, M. (1993) Mesoderm induction and pattern formation in the amphibian embryo. In Cell-Cell Signalling in Vertebrate Development, E.J. Robertson, F.R. Maxfield and H.J. Vogel (eds.), Academic Press, Inc., New York, pp. 33-48.

Rebagliati, M. R. and Dawid, I.B. (1993) Expression of activin transcripts in follicle cells and oocytes of
Xenopus laevis. Dev. Biol. 159, 574-580.