ZFIN ID: ZDB-PERS-960805-332
Lewis, Katharine E.
Email: kelewi02@syr.edu
URL:
Affiliation: Lewis Lab - Syracuse
Address: Department of Biology Syracuse University 107 College Place Syracuse NY 13244, USA
Country: United Kingdom
Phone: 315 443 5902
Fax:
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS
Specification and patterning of motoneurons and interneurons; dorsal-ventral neural tube patterning; Evolution of vertebrate spinal cord patterning and function; Hedgehog signalling.


PUBLICATIONS
Juárez-Morales, J.L., Martinez-De Luna, R.I., Zuber, M.E., Roberts, A., Lewis, K.E. (2017) Zebrafish transgenic constructs label specific neurons in Xenopus laevis spinal cord and identify frog V0v spinal neurons. Developmental Neurobiology. 77(8):1007-1020
Hilinski, W.C., Bostrom, J.R., England, S.J., Juárez-Morales, J.L., de Jager, S., Armant, O., Legradi, J., Strähle, U., Link, B.A., Lewis, K.E. (2016) Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons. Neural Development. 11:16
England, S., Hilinski, W., de Jager, S., Andrzejczuk, L., Campbell, P., Chowdhury, T., Demby, C., Fancher, W., Gong, Y., Lin, C., Machikas, A., Rodriguez-Larrain, G., Roman Rivera, V., and Lewis, K.E. (2014) Identifying Transcription Factors Expressed by Ventral Spinal Cord Interneurons. ZFIN Direct Data Submission.
England, S., Batista, M.F., Mich, J.K., Chen, J.K., and Lewis, K.E. (2011) Roles of Hedgehog pathway components and retinoic acid signalling in specifying zebrafish ventral spinal cord neurons. Development (Cambridge, England). 138(23):5121-5134
Goode, D.K., Callaway, H.A., Cerda, G.A., Lewis, K.E., and Elgar, G. (2011) Minor change, major difference: divergent functions of highly conserved cis-regulatory elements subsequent to whole genome duplication events. Development (Cambridge, England). 138(5):879-884
Schulte, C.J., Allen, C., England, S.J., Juárez-Morales, J.L., and Lewis, K.E. (2011) Evx1 is required for joint formation in zebrafish fin dermoskeleton. Developmental dynamics : an official publication of the American Association of Anatomists. 240(5):1240-1248
Wotton, K.R., Weierud, F.K., Juárez-Morales, J.L., Alvares, L.E., Dietrich, S., and Lewis, K.E. (2009) Conservation of gene linkage in dispersed vertebrate NK homeobox clusters. Development genes and evolution. 219(9-10):481-496
Cerda, G.A., Hargrave, M., and Lewis, K.E. (2009) RNA profiling of FAC-sorted neurons from the developing zebrafish spinal cord. Developmental dynamics : an official publication of the American Association of Anatomists. 238(1):150-161
Batista, M.F., and Lewis, K.E. (2008) Pax2/8 act redundantly to specify glycinergic and GABAergic fates of multiple spinal interneurons. Developmental Biology. 323(1):88-97
Batista, M.F., Jacobstein, J., and Lewis, K.E. (2008) Zebrafish V2 cells develop into excitatory CiD and Notch signalling dependent inhibitory VeLD interneurons. Developmental Biology. 322(2):263-275
Wotton, K.R., Weierud, F.K., Dietrich, S., and Lewis, K.E. (2008) Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates. BMC Evolutionary Biology. 8:171
Lupo, G., Harris, W.A., and Lewis, K.E. (2006) Mechanisms of ventral patterning in the vertebrate nervous system. Nature Reviews Neuroscience. 7(2):103-114
Lewis, K.E. (2006) How do genes regulate simple behaviours? Understanding how different neurons in the vertebrate spinal cord are genetically specified. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 361(1465):45-66
Lewis, K.E., Bates, J., and Eisen, J.S. (2005) Regulation of iro3 expression in the zebrafish spinal cord. Developmental dynamics : an official publication of the American Association of Anatomists. 232(1):140-148
Wolff, C., Roy, S., Lewis, K.E., Schauerte, H., Joerg-Rauch, G., Kirn, A., Weiler, C., Geisler, R., Haffter, P., Ingham, P.W. (2004) iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo. Genes and Development. 18(13):1565-1576
Lewis, K.E., and Eisen, J.S. (2004) Paraxial mesoderm specifies zebrafish primary motoneuron subtype identity. Development (Cambridge, England). 131(4):891-902
Lewis, K.E. and Eisen, J.S. (2003) From cells to circuits: development of the zebrafish spinal cord. Prog. Neurobiol.. 69(6):419-449
Varga, Z.M., Amores, A., Lewis, K.E., Yan, Y.-L., Postlethwait, J.H., Eisen, J.S., and Westerfield, M. (2001) Zebrafish smoothened functions in ventral neural tube specification and axon tract formation. Development (Cambridge, England). 128(18):3497-3509
Lewis, K.E. and Eisen, J.S. (2001) Hedgehog signaling is required for primary motoneuron induction in zebrafish. Development (Cambridge, England). 128(18):3485-3495
Lewis, K.E., Currie, P.D., Roy, S., Schauerte, H., Haffter, P., and Ingham, P.W. (1999) Control of muscle cell-type specification in the zebrafish embryo by hedgehog signalling. Developmental Biology. 216(2):469-480
Lewis, K.E., Concordet, J.P., and Ingham, P.W. (1999) Characterisation of a second patched gene in the zebrafish Danio rerio and the differential response of patched genes to hedgehog signalling. Developmental Biology. 208:14-29
Concordet, J.P., Lewis, K.E., Moore, J.W., Goodrich, L.V., Johnson, R.L., Scott, M.P., and Ingham, P.W. (1996) Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning. Development (Cambridge, England). 122(9):2835-2846

NON-ZEBRAFISH PUBLICATIONS
G. Cooke, K. Lewis and R. Keynes (2008) Segmentation: Spinal cord segmentation - A-P somite patterning, The New Encyclopedia of Neuroscience, edited by Larry Squire et al. Elsevier.

Drossopoulou, G., Lewis, K. E., Sanz-Ezquerro, J. J., Nikbakht, N., McMahon, A. P., Hofmann, C. and Tickle, C.(2000) A model for antero-posterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling. Development 127(7): 1337-1348 http://www.biologists.com/Development/127/07/dev2527.html

K. E. Lewis, G. Drossopoulou, I. R. Paton, D. R. Morrice, K. E. Robertson, D. W. Burt, P. W. Ingham and C. Tickle (1999) 'Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh Pathway.' Development 126: 2297-2407

Morrison, Concoran & Lewis (1992) 'The determination of particle size distributions in small-angle scattering usingthe maximum-entropy method' J. Appl. Cryst 25: 504 - 513