ZFIN ID: ZDB-PERS-230327-3
Yuan, Shiaulou
Email: shiaulou.yuan@mgh.harvard.edu
URL: https://yuan.mgh.harvard.edu
Affiliation: Yuan Lab
Address: Massachusetts General Hospital 149 13th St., CVRC 4215 Boston, MA 02129
Phone: 617-643-6343
ORCID ID: 0000-0002-5061-6132

Dr. Shiaulou Yuan is an Assistant Professor of Medicine at Massachusetts General Hospital and Harvard Medical School. Dr. Yuan received his undergraduate degree in molecular cell biology from University of California, Berkeley in 2004 under Dr. Athanasios Theologis. He completed his Ph.D. in genetics from Yale University in 2011 with Dr. Zhaoxia Sun. Dr. Yuan performed his postdoctoral training in cardiovascular biology and developmental biology with Dr. Martina Brueckner at Yale School of Medicine. He received additional postdoctoral training in light sheet microscopy, laser nanosurgery techniques, and biophysical approaches with Dr. Joe Howard at Yale University and Dr. Scott Fraser at University of Southern California. In 2018, he started his own independent laboratory in the Cardiovascular Research Center at Massachusetts General Hospital and Harvard Medical School. Dr. Yuan’s research focuses on elucidating the cellular and molecular mechanisms that shape the developing heart, and in particular, the function of cilia in this process.

Djenoune, L., Mahamdeh, M., Truong, T.V., Nguyen, C.T., Fraser, S.E., Brueckner, M., Howard, J., Yuan, S. (2023) Cilia function as calcium-mediated mechanosensors that instruct left-right asymmetry. Science (New York, N.Y.). 379:717871-78
Akerberg, A.A., Trembley, M., Butty, V., Schwertner, A., Zhao, L., Beerens, M., Liu, X., Mahamdeh, M., Yuan, S., Boyer, L., MacRae, C., Nguyen, C., Pu, W.T., Burns, C.E., Burns, C.G. (2022) RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function. Circulation research. 131(12):980-1000
Li, Y., Zhao, L., Yuan, S., Zhang, J., Sun, Z. (2017) Axonemal dynein assembly requires the R2TP complex component Pontin. Development (Cambridge, England). 144(24):4684-4693
Xu, W., Jin, M., Hu, R., Wang, H., Zhang, F., Yuan, S., Cao, Y. (2017) The Joubert Syndrome Protein Inpp5e Controls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane. Journal of the American Society of Nephrology : JASN. 28(1):118-129
Yuan, S., Brueckner, M. (2016) Visualization and Manipulation of Cilia and Intraciliary Calcium in the Zebrafish Left-Right Organizer. Methods in molecular biology (Clifton, N.J.). 1454:123-47
Yuan, S., Zhao, L., Brueckner, M., Sun, Z. (2015) Intraciliary Calcium Oscillations Initiate Vertebrate Left-Right Asymmetry. Current biology : CB. 25(5):556-67
Zhao, L., Yuan, S., Cao, Y., Kallakuri, S., Li, Y., Kishimoto, N., Dibella, L., and Sun, Z. (2013) Reptin/Ruvbl2 is a Lrrc6/Seahorse interactor essential for cilia motility. Proceedings of the National Academy of Sciences of the United States of America. 110(31):12697-702
Paavola, J., Schliffke, S., Rossetti, S., Kuo, I.Y., Yuan, S., Sun, Z., Harris, P.C., Torres, V.E., and Ehrlich, B.E. (2013) Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy. Journal of Molecular and Cellular Cardiology. 58:199-208
Yuan, S., Zhao, L., and Sun, Z. (2013) Dissecting the Functional Interplay Between the TOR Pathway and the Cilium in Zebrafish. Methods in enzymology. 525:159-189
Yuan, S., Li, J., Diener, D.R., Choma, M.A., Rosenbaum, J.L., and Sun, Z. (2012) Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation. Proceedings of the National Academy of Sciences of the United States of America. 109(6):2021-2026
Malicki, J., Avanesov, A., Li, J., Yuan, S., and Sun, Z. (2011) Analysis of cilia structure and function in zebrafish. Methods (San Diego, Calif.). 101:39-74
Yuan, S., and Sun, Z. (2009) Microinjection of mRNA and morpholino antisense oligonucleotides in zebrafish embryos. Journal of visualized experiments : JoVE. (27)