ZFIN ID: ZDB-PERS-090709-1
Ono, Fumihito
Email: fumihito.ono@ompu.ac.jp
URL: https://www.ompu.ac.jp/department/physiology/Physiology-index.html
Affiliation: Department of Physiology, Osaka Medical and Pharmaceutical University
Address: Professor and Chair, Department of Physiology, Osaka Medical and Pharmaceutical University 2-7 Diagaku-machi Takatsuki Osaka Japan 569-8686
Country: Japan
Phone: 81-72-684-6421
Fax: 072-684-6521
ORCID ID: 0000-0001-7532-5262


BIOGRAPHY AND RESEARCH INTERESTS
1991 M.D., Faculty of Medicine, University of Tokyo
1991 Resident, Internal Medicine, National Medical Center Hospital, Tokyo, Japan
1996 Ph.D., Faculty of Medicine, University of Tokyo
1996 Postdoctoral Fellow, the Japan Society for the Promotion of Science, Tsukuba, Japan
1998 Postdoctoral Fellow, SUNY at Stony Brook
2000 Research Assistant Professor, SUNY at Stony Brook
2003 Assistant Professor, the Whitney Laboratory for Marine Bioscience & Department of Neuroscience, University of Florida
2007 Chief, Section on Model Synaptic Systems, Laboratory of Molecular Physiology, NIAAA/NIH
2014 Professor&Chair, Department of Physiology, Osaka Medical College


PUBLICATIONS
Egashira, Y., Kumade, A., Ojida, A., Ono, F. (2022) Spontaneously recycling synaptic vesicles constitute readily releasable vesicles in intact neuromuscular synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. 42(17):3523-3536
Zempo, B., Tanaka, N., Daikoku, E., Ono, F. (2021) High-speed camera recordings uncover previously unidentified elements of zebrafish mating behaviors integral to successful fertilization. Scientific Reports. 11:20228
Zempo, B., Yamamoto, Y., Williams, T., Ono, F. (2020) Synaptic silencing of fast muscle is compensated by rewired innervation of slow muscle. Science advances. 6:eaax8382
Fujii, K., Nakajo, K., Egashira, Y., Yamamoto, Y., Kitada, K., Taniguchi, K., Kawai, M., Tomiyama, H., Kawakami, K., Uchiyama, K., Ono, F. (2020) Gastrointestinal Neurons Expressing HCN4 Regulate Retrograde Peristalsis. Cell Reports. 30:2879-2888.e3
Li, L., Jiao, X., D'Atri, I., Ono, F., Nelson, R., Chan, C.C., Nakaya, N., Ma, Z., Ma, Y., Cai, X., Zhang, L., Lin, S., Hameed, A., Chioza, B.A., Hardy, H., Arno, G., Hull, S., Khan, M.I., Fasham, J., Harlalka, G.V., Michaelides, M., Moore, A.T., Coban Akdemir, Z.H., Jhangiani, S., Lupski, J.R., Cremers, F.P.M., Qamar, R., Salman, A., Chilton, J., Self, J., Ayyagari, R., Kabir, F., Naeem, M.A., Ali, M., Akram, J., Sieving, P.A., Riazuddin, S., Baple, E.L., Riazuddin, S.A., Crosby, A.H., Hejtmancik, J.F. (2018) Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa. PLoS Genetics. 14:e1007504
Mott, M., Luna, V.M., Park, J.Y., Downes, G.B., Epley, K., Ono, F. (2017) Expressing acetylcholine receptors after innervation suppresses spontaneous vesicle release and causes muscle fatigue. Scientific Reports. 7:1674
Torvund, M.M., Ma, T.S., Connaughton, V.P., Ono, F., Nelson, R.F. (2017) Cone signals in monostratified and bistratified amacrine cells of adult zebrafish retina. The Journal of comparative neurology. 525(7):1532-1557
Luna, V.M., Daikoku, E., Ono, F. (2015) "Slow" skeletal muscles across vertebrate species. Cell & Bioscience. 5:62
Park, J.Y., Mott, M., Williams, T., Ikeda, H., Wen, H., Linhoff, M., Ono, F. (2014) A Single Mutation in the Acetylcholine Receptor δ-Subunit Causes Distinct Effects in Two Types of Neuromuscular Synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34:10211-10218
Puhl, H.L., Lu, V.B., Won, Y.J., Sasson, Y., Hirsch, J.A., Ono, F., Ikeda, S.R. (2014) Ancient Origins of RGK Protein Function: Modulation of Voltage-Gated Calcium Channels Preceded the Protostome and Deuterostome Split. PLoS One. 9:e100694
Fero, K., Bergeron, S.A., Horstick, E.J., Codore, H., Li, G.H., Ono, F., Dowling, J.J., and Burgess, H.A. (2014) Impaired embryonic motility in dusp27 mutants reveals a developmental defect in myofibril structure. Disease models & mechanisms. 7(2):289-98
Ikeda, H., Delargy, A.H., Yokogawa, T., Urban, J.M., Burgess, H.A., and Ono, F. (2013) Intrinsic properties of larval zebrafish neurons in ethanol. PLoS One. 8(5):e63318
Walogorsky, M., Mongeon, R., Wen, H., Nelson, N.R., Urban, J.M., Ono, F., Mandel, G., and Brehm, P. (2012) Zebrafish model for congenital myasthenic syndrome reveals mechanisms causal to developmental recovery. Proceedings of the National Academy of Sciences of the United States of America. 109(43):17711-17716
Papke, R.L., Ono, F., Stokes, C., Urban, J., and Boyd, R.T. (2012) The nicotinic acetylcholine receptors of zebrafish and an evaluation of pharmacological tools used for their study. Biochemical pharmacology. 84(3):352-365
Park, J.Y., Ikeda, H., Ikenaga, T., and Ono, F. (2012) Acetylcholine receptors enable the transport of rapsyn from the Golgi complex to the plasma membrane. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(21):7356-7363
Nakayama, S., Ikenaga, T., Kawakami, K., Ono, F., and Hatta, K. (2012) Transgenic line with gal4 insertion useful to study morphogenesis of craniofacial perichondrium, vascular endothelium-associated cells, floor plate, and dorsal midline radial glia during zebrafish development. Development, growth & differentiation. 54(2):202-215
Won, Y.J., Ono, F., and Ikeda, S.R. (2012) Characterization of na(+) and ca(2+) channels in zebrafish dorsal root ganglion neurons. PLoS One. 7(8):e42602
Mongeon, R., Walogorsky, M., Urban, J., Mandel, G., Ono, F., and Brehm, P. (2011) An acetylcholine receptor lacking both γ and ε subunits mediates transmission in zebrafish slow muscle synapses. The Journal of general physiology. 138(3):353-66
Ikenaga, T., Urban, J.M., Gebhart, N., Hatta, K., Kawakami, K., and Ono, F. (2011) Formation of the spinal network in zebrafish determined by domain-specific pax genes. The Journal of comparative neurology. 519(8):1562-1579
Diep, C.Q., Ma, D., Deo, R.C., Holm, T.M., Naylor, R.W., Arora, N., Wingert, R.A., Bollig, F., Djordjevic, G., Lichman, B., Zhu, H., Ikenaga, T., Ono, F., Englert, C., Cowan, C.A., Hukriede, N.A., Handin, R.I., and Davidson, A.J. (2011) Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature. 470(7332):95-100
Won, Y.J., Ono, F., and Ikeda, S.R. (2011) Identification and Modulation of Voltage-gated Ca2+ currents in Zebrafish Rohon-Beard Neurons. Journal of neurophysiology. 105(1):442-453
Epley, K.E., Urban, J.M., Ikenaga, T., and Ono, F. (2008) A modified acetylcholine receptor delta-subunit enables a null mutant to survive beyond sexual maturation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(49):13223-13231
Luna, V.M., Wang, M., Ono, F., Gleason, M.R., Dallman, J.E., Mandel, G., and Brehm, P. (2004) Persistent electrical coupling and locomotory dysfunction in the zebrafish mutant shocked. Journal of neurophysiology. 92(4):2003-2009
Ibanez-Tallon, I., Wen, H., Miwa, J.M., Xing, J., Tekinay, A.B., Ono, F., Brehm, P., and Heintz, N. (2004) Tethering naturally occurring Peptide toxins for cell-autonomous modulation of ion channels and receptors in vivo. Neuron. 43(3):305-311
Ono, F., Mandel, G., and Brehm, P. (2004) Acetylcholine receptors direct rapsyn clusters to the neuromuscular synapse in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(24):5475-5481

NON-ZEBRAFISH PUBLICATIONS
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