ZFIN ID: ZDB-PERS-050506-2
Leung, Yuk Fai
Email: yfleung@purdue.edu
URL: https://www.bio.purdue.edu/People/faculty_dm/directory.php?refID=596
Affiliation: Leung Lab
Address: Department of Biological Sciences Purdue University LILY 2-136, 915 W. State Street West Lafayette, IN 47907 USA
Country: United States
Phone: 765-496-3153
Fax: 765-494-0876

Please see our lab research interests

Ganzen, L., Ko, M.J., Zhang, M., Xie, R., Chen, Y., Zhang, L., James, R., Mumm, J., van Rijn, R.M., Zhong, W., Pang, C.P., Zhang, M., Tsujikawa, M., Leung, Y.F. (2021) Drug screening with zebrafish visual behavior identifies carvedilol as a potential treatment for an autosomal dominant form of retinitis pigmentosa. Scientific Reports. 11:11432
Ko, M.J., Ganzen, L.C., Coskun, E., Mukadam, A.A., Leung, Y.F., van Rijn, R.M. (2019) A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery. Scientific Reports. 9:2430
Xie, R., Zhang, M., Venkatraman, P., Zhang, X., Zhang, G., Carmer, R., Kantola, S.A., Pang, C.P., Ma, P., Zhang, M., Zhong, W., Leung, Y.F. (2019) Normalization of large-scale behavioural data collected from zebrafish. PLoS One. 14:e0212234
Weaver, C.J., Terzi, A., Roeder, H., Gurol, T., Deng, Q., Fai Leung, Y., Suter, D.M. (2018) nox2/cybb deficiency affects zebrafish retinotectal connectivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(26):5854-5871
Huang, X.F., Xiang, L., Cheng, W., Cheng, F.F., He, K.W., Zhang, B.W., Zheng, S.S., Han, R.Y., Zheng, Y.H., Xu, X.T., Yu, H.Y., Zhuang, W., Leung, Y.F., Jin, Z.B. (2018) Mutation of IPO13 causes recessive ocular coloboma, microphthalmia, and cataract. Experimental & molecular medicine. 50:53
Liu, Y., Ma, P., Cassidy, P.A., Carmer, R., Zhang, G., Venkatraman, P., Brown, S.A., Pang, C.P., Zhong, W., Zhang, M., Leung, Y.F. (2017) Statistical Analysis of Zebrafish Locomotor Behaviour by Generalized Linear Mixed Models. Scientific Reports. 7:2937
Ganzen, L., Venkatraman, P., Pang, C.P., Leung, Y.F., Zhang, M. (2017) Utilizing Zebrafish Visual Behaviors in Drug Screening for Retinal Degeneration. International Journal of Molecular Sciences. 18(6):1185
Hensley, M.R., Chua, R.F., Leung, Y.F., Yang, J.Y., Zhang, G. (2016) Molecular Evolution of MDM1, a "Duplication-Resistant" Gene in Vertebrates. PLoS One. 11:e0163229
Hensley, M.R., Cui, Z., Chua, R.F., Simpson, S., Shammas, N.L., Yang, J.Y., Leung, Y.F., Zhang, G. (2016) Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development. Scientific Reports. 6:27816
Zhang, L., Xiang, L., Liu, Y., Venkatraman, P., Chong, L., Cho, J., Bonilla, S., Jin, Z.B., Pang, C.P., Ko, K.M., Ma, P., Zhang, M., Leung, Y.F. (2016) A Naturally-Derived Compound Schisandrin B Enhanced Light Sensation in the pde6c Zebrafish Model of Retinal Degeneration. PLoS One. 11:e0149663
Gao, Y., Zhang, G., Jelfs, B., Carmer, R., Venkatraman, P., Ghadami, M., Brown, S.A., Pang, C.P., Leung, Y.F., Chan, R.H., Zhang, M. (2016) Computational classification of different wild-type zebrafish strains based on their variation in light-induced locomotor response. Computers in Biology and Medicine. 69:1-9
Liu, Y., Carmer, R., Zhang, G., Venkatraman, P., Brown, S.A., Pang, C.P., Zhang, M., Ma, P., Leung, Y.F. (2015) Statistical Analysis of Zebrafish Locomotor Response. PLoS One. 10:e0139521
Bishop, B., Ho, K.K., Tyler, K., Smith, A., Bonilla, S., Leung, Y.F., Ogas, J. (2015) The chromatin remodeler chd5 is necessary for proper head development during embryogenesis of Danio rerio. Biochimica et biophysica acta. Gene regulatory mechanisms. 1849(8):1040-50
Gao, Y., Chan, R.H., Chow, T.W., Zhang, L., Bonilla, S., Pang, C.P., Zhang, M., Leung, Y.F. (2014) A High-Throughput Zebrafish Screening Method for Visual Mutants by Light-Induced Locomotor Response. IEEE/ACM transactions on computational biology and bioinformatics. 11(4):693-701
Zhang, L., Bonilla, S., Zhang, Y., and Leung, Y.F. (2014) p35 promotes the differentiation of amacrine cell subtype in the zebrafish retina under the regulation of egr1. Developmental Dynamics : an official publication of the American Association of Anatomists. 243(2):315-23
Zhang, L., Ma, P., Collery, R., Trowbridge, S., Zhang, M., Zhong, W., and Leung, Y.F. (2014) Expression profiling of the RPE in zebrafish smarca4 mutant revealed altered signals that potentially affect RPE and retinal differentiation. Molecular Vision. 20:56-72
Zhang, Y., Bonilla, S., Chong, L., and Leung, Y.F. (2013) Irx7, a Smarca4-regulated gene for retinal differentiation, regulates other genes controlled by Smarca4 in zebrafish retinas. Gene expression patterns : GEP. 13(5-6):177-82
Li, Z., Zhang, L., and Leung, Y.F. (2013) Use of the zebrafish model to study refractive error. Expert Review of Ophthalmology. 8(1):1-3
Zhang, L., Cho, J., Ptak, D., and Leung, Y.F. (2013) The Role of egr1 in Early Zebrafish Retinogenesis. PLoS One. 8(2):e56108
Zhang, L., Chong, L., Cho, J., Liao, P.C., Shen, F., and Leung, Y.F. (2012) Drug Screening to Treat Early-Onset Eye Diseases: Can Zebrafish Expedite the Discovery?. Asia-Pacific Journal of Ophthalmology. 1(6):374-383
Zhang, Y., Yang, Y., Trujillo, C., Zhong, W., and Leung, Y.F. (2012) The Expression of irx7 in the Inner Nuclear Layer of Zebrafish Retina Is Essential for a Proper Retinal Development and Lamination. PLoS One. 7(4):e36145
Li, Z., Ptak, D., Zhang, L., Walls, E.K., Zhong, W., and Leung, Y.F. (2012) Phenylthiourea specifically reduces zebrafish eye size. PLoS One. 7(6):e40132
Hensley, M.R., Emran, F., Bonilla, S., Zhang, L., Zhong, W., Grosu, P., Dowling, J.E., and Leung, Y.F. (2011) Cellular Expression of Smarca4 (Brg1)-regulated Genes in Zebrafish Retinas. BMC Developmental Biology. 11(1):45
Zhang, L., and Leung, Y.F. (2010) Microdissection of zebrafish embryonic eye tissues. Journal of visualized experiments : JoVE. (40)
Hensley, M.R., and Leung, Y.F. (2010) A Convenient Dry Feed for Raising Zebrafish Larvae. Zebrafish. 7(2):219-231
Leung, Y.F., Ma, P., Link, B.A., and Dowling, J.E. (2008) Factorial microarray analysis of zebrafish retinal development. Proceedings of the National Academy of Sciences of the United States of America. 105(35):12909-12914
Leung, Y.F., Ma, P., and Dowling, J.E. (2007) Gene expression profiling of zebrafish embryonic retinal pigment epithelium in vivo. Investigative ophthalmology & visual science. 48(2):881-890
Leung, Y.F., and Dowling, J.E. (2005) Gene Expression Profiling of Zebrafish Embryonic Retina. Zebrafish. 2(4):269-283

Selected Publications
  1. Leung YF, Cavalieri D. Fundamentals of cDNA microarray analysis. Trends Genet. 2003; 19:649-659. [PubMed]

  2. Leung YF, Tam PO, Lee WS,Lam DS, Yam HF, Fan BJ, Tham CC, Chua JK, Pang CP. The dual role of dexamethasone on anti-inflammation and outflow resistance demonstrated in cultured human trabecular meshwork cells. Mol Vis. 2003;9:425-39. [PubMed]

  3. Leung YF, Fan BJ, Lam DSC, Lee WS, Tam POS, Chua JKH, Tham CCY, Lai JSM, Fan DSP, Pang CP. Different Optineurin Mutation Pattern in Chinese Primary Open Angle Glaucoma Patients. Invest Ophthalmol Vis Sci. 2003;44(9):3880-4. [PubMed]

  4. Pang CP, Leung YF, Fan BJ, Baum L, Tong WC, Lee WS, Chua JKH, Fan DSP, Liu Y, Lam DSC. TIGR/MYOC Gene Sequence Alterations in Individuals with and without Primary Open Angle Glaucoma. Invest Ophthalmol Vis Sci. 2002; 43:3231-3235. [PubMed]

  5. Leung YF, Pang CP, Lam DSC. Microarray software review. In: A practical approach to microarray data analysis. D.P. Berrar, W. Dubitzky and M. Granzow, (Eds.), Kluwer academic, 2002.

  6. Leung YF, Pang CP. Eye on bioinformatics - dissecting complex disease trait in silico. Applied Bioinformatics. 2002; 1:69-80. [PubMed]

  7. Leung YF, Tam POS, Tong WC, Choy KW, Lam DSC, Pang CP. High throughput conformation sensitive gel electrophoresis (HTCSGE) for rapid detection of novel single nucleotide polymorphisms (SNPs). Biotechniques. 2001; 30:334-340. [PubMed]

  8. Leung YF, Pang CP, Browne K. Guide to microarray hardware - a researcher perspective. Lab-on-a-chip.com 2001. (http://lab-on-a-chip.com/suppliers/comptab.asp)

  9. Leung YF, Baum L, Lam DSC, Fan DSP, Chua JKH, Pang CP. Absence of trabecular meshwork inducible stretch response (TISR)/oculomedin gene and proximal promoter mutation in primary open angle glaucoma patients. Hum Genet. 2000;
    107:404-5. [PubMed]

  10. Leung YF, Tam POS, Baum L, Chan WM, Lam DSC, Pang CP. Cost Savings Using Automated DNA Sequencing. Biotechniques. 2000; 29:544. [PubMed]

  11. Lam DSC, Leung YF, Chua JKH, Baum L, Fan DS, Choy KW, Pang CP. Truncations in the TIGR gene in individuals with and without primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2000; 41:1386-91. [PubMed]