ZFIN ID: ZDB-PERS-001113-4
Seiler, Christoph
Email: cseiler@mail.med.upenn.edu
Affiliation: Pack Lab
Address: Department of Medicine University of Pennsylvania School of Medicine 1230 Biomedical Research Building II/III 421 Curie Boulevard Philadelphia, PA 19104 USA
Country: United States
Phone: (215) 573-7562


Sheppard, S.E., March, M.E., Seiler, C., Matsuoka, L.S., Kim, S.E., Kao, C., Rubin, A.I., Battig, M.R., Khalek, N., Schindewolf, E., O'Connor, N., Pinto, E., Priestley, J.R., Sanders, V.R., Niazi, R., Ganguly, A., Hou, C., Slater, D., Frieden, I.J., Huynh, T., Shieh, J.T., Krantz, I.D., Guerrero, J.C., Surrey, L.F., Biko, D.M., Laje, P., Castelo-Soccio, L., Nakano, T.A., Snyder, K., Smith, C.L., Li, D., Dori, Y., Hakonarson, H. (2023) Lymphatic disorders caused by mosaic, activating KRAS variants respond to MEK inhibition. JCI insight. 8(9):
Haroon, S., Yoon, H., Seiler, C., Osei-Frimpong, B., He, J., Nair, R.M., Mathew, N.D., Burg, L., Kose, M., Venkata, C., Anderson, V.E., Nakamaru-Ogiso, E., Falk, M.J. (2023) N-Acetylcysteine and cysteamine bitartrate prevent azide-induced neuromuscular decompensation by restoring glutathione balance in two novel surf1-/- zebrafish deletion models of Leigh syndrome. Human molecular genetics. 32(12):1988-2004
Lavorato, M., Nakamaru-Ogiso, E., Mathew, N.D., Herman, E., Shah, N.K., Haroon, S., Xiao, R., Seiler, C., Falk, M.J. (2022) Dichloroacetate improves mitochondrial function, physiology, and morphology in FBXL4 disease models. JCI insight. 7(16)
Guha, S., Mathew, N.D., Konkwo, C., Ostrovsky, J., Kwon, Y.J., Polyak, E., Seiler, C., Bennett, M., Xiao, R., Zhang, Z., Nakamaru-Ogiso, E., Falk, M.J. (2021) Combinatorial glucose, nicotinic acid, and N-acetylcysteine therapy has synergistic effect in preclinical C. elegans and zebrafish models of mitochondrial complex I disease. Human molecular genetics. 30(7):536-551
Li, D., March, M.E., Gutierrez-Uzquiza, A., Kao, C., Seiler, C., Pinto, E., Matsuoka, L.S., Battig, M.R., Bhoj, E.J., Wenger, T.L., Tian, L., Robinson, N., Wang, T., Liu, Y., Weinstein, B.M., Swift, M., Jung, H.M., Kaminski, C.N., Chiavacci, R., Perkins, J.A., Levine, M.A., Sleiman, P.M.A., Hicks, P.J., Strausbaugh, J.T., Belasco, J.B., Dori, Y., Hakonarson, H. (2019) ARAF recurrent mutation causes central conducting lymphatic anomaly treatable with a MEK inhibitor. Nature medicine. 25(7):1116-1122
Guha, S., Konkwo, C., Lavorato, M., Mathew, N.D., Peng, M., Ostrovsky, J., Kwon, Y.J., Polyak, E., Lightfoot, R., Seiler, C., Xiao, R., Bennett, M., Zhang, Z., Nakamaru-Ogiso, E., Falk, M.J. (2019) Pre-clinical evaluation of cysteamine bitartrate as a therapeutic agent for mitochondrial respiratory chain disease. Human molecular genetics. 28(11):1837-1852
Li, D., Wenger, T.L., Seiler, C., March, M.E., Gutierrez-Uzquiza, A., Kao, C., Bhoj, E., Tian, L., Rosenbach, M., Liu, Y., Robinson, N., Behr, M., Chiavacci, R., Hou, C., Wang, T., Bakay, M., Pellegrino da Silva, R., Perkins, J.A., Sleiman, P., Levine, M.A., Hicks, P.J., Itkin, M., Dori, Y., Hakonarson, H. (2018) Pathogenic variant in EPHB4 results in central conducting lymphatic anomaly. Human molecular genetics. 27(18):3233-3245
Polyak, E., Ostrovsky, J., Peng, M., Dingley, S.D., Tsukikawa, M., Kwon, Y.J., McCormack, S.E., Bennett, M., Xiao, R., Seiler, C., Zhang, Z., Falk, M.J. (2018) N-acetylcysteine and vitamin E rescue animal longevity and cellular oxidative stress in pre-clinical models of mitochondrial complex I disease. Molecular genetics and metabolism. 123(4):449-462
Byrnes, J., Ganetzky, R., Lightfoot, R., Tzeng, M., Nakamaru-Ogiso, E., Seiler, C., Falk, M.J. (2017) Pharmacologic modeling of primary mitochondrial respiratory chain dysfunction in zebrafish. Neurochemistry international. 117:23-34
Abrams, J., Einhorn, Z., Seiler, C., Zong, A.B., Sweeney, H.L., Pack, M. (2016) Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility, and vascular function in zebrafish. Disease models & mechanisms. 9(5):529-40
Seiler, C., Gebhart, N., Zhang, Y., Shinton, S.A., Li, Y.S., Ross, N.L., Liu, X., Li, Q., Bilbee, A.N., Varshney, G.K., LaFave, M.C., Burgess, S.M., Balciuniene, J., Balciunas, D., Hardy, R.R., Kappes, D.J., Wiest, D.L., Rhodes, J. (2015) Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish. PLoS One. 10:e0131908
Abrams, J., Davuluri, G., Seiler, C., and Pack, M. (2012) Smooth muscle caldesmon modulates peristalsis in the wild type and non-innervated zebrafish intestine. Neurogastroenterology and motility. 24(3):288-299
Seiler, C., Davuluri, G., Abrams, J., Byfield, F.J., Janmey, P.A., and Pack, M. (2012) Smooth muscle tension induces invasive remodeling of the zebrafish intestine. PLoS Biology. 10(9):e1001386
Seiler, C., and Pack, M. (2011) Transgenic labeling of the zebrafish pronephric duct and tubules using a promoter from the enpep gene. Gene expression patterns : GEP. 11(1-2):118-121
Seiler, C., Abrams, J., and Pack, M. (2010) Characterization of zebrafish intestinal smooth muscle development using a novel sm22{alpha}-b promoter. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(11):2806-2812
Davuluri, G., Seiler, C., Abrams, J., Soriano, A.J., and Pack, M. (2010) Differential effects of thin and thick filament disruption on zebrafish smooth muscle regulatory proteins. Neurogastroenterology and motility. 22(10):1100-e285
Zheng, X., Xu, C., Di Lorenzo, A., Kleaveland, B., Zou, Z., Seiler, C., Chen, M., Cheng, L., Xiao, J., He, J., Pack, M.A., Sessa, W.C., and Kahn, M.L. (2010) CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations. J. Clin. Invest.. 120(8):2795-2804
Lucitt, M.B., Price, T.S., Pizarro, A., Wu, W., Yocum, A.K., Seiler, C., Pack, M.A., Blair, I.A., Fitzgerald, G.A., and Grosser, T. (2008) Analysis of the zebrafish proteome during embryonic development. Molecular & cellular proteomics : MCP. 7(5):981-994
Obholzer, N., Wolfson, S., Trapani, J.G., Mo, W., Nechiporuk, A., Busch-Nentwich, E., Seiler, C., Sidi, S., Söllner, C., Duncan, R.N., Boehland, A., and Nicolson, T. (2008) Vesicular glutamate transporter 3 is required for synaptic transmission in zebrafish hair cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(9):2110-2118
Geisler, R., Rauch, G.J., Geiger-Rudolph, S., Albrecht, A., van Bebber, F., Berger, A., Busch-Nentwich, E., Dahm, R., Dekens, M.P., Dooley, C., Elli, A.F.,Gehring, I., Geiger, H., Geisler, M., Glaser, S., Holley, S., Huber, M., Kerr, A., Kirn, A., Knirsch, M., Konantz, M., Kuchler, A.M., Maderspacher, F., Neuhauss, S.C., Nicolson, T., Ober, E.A., Praeg, E., Ray, R., Rentzsch, B., Rick, J.M., Rief, E., Schauerte, H.E., Schepp, C.P., Schonberger, U., Schonthaler, H.B., Seiler, C., Sidi, S., Söllner, C., Wehner, A., Weiler, C., Nüsslein-Volhard, C. (2007) Large-scale mapping of mutations affecting zebrafish development. BMC Genomics. 8(1):11
Wallace, K.N., Dolan, A.C., Seiler, C., Smith, E.M., Yusuff, S., Chaille-Arnold, L., Judson, B., Sierk, R., Yengo, C., Sweeney, H.L., and Pack, M. (2005) Mutation of smooth muscle Myosin causes epithelial invasion and cystic expansion of the zebrafish intestine. Developmental Cell. 8(5):717-726
Seiler, C., Finger-Baier, K.C., Rinner, O., Makhankov, Y.V., Schwarz, H., Neuhauss, S.C., and Nicolson, T. (2005) Duplicated genes with split functions: independent roles of protocadherin15 orthologues in zebrafish hearing and vision. Development (Cambridge, England). 132(3):615-623
Seiler, C., Ben-David, O., Sidi, S., Hendrich, O., Rusch, A., Burnside, B., Avraham, K.B., and Nicolson, T. (2004) Myosin VI is required for structural integrity of the apical surface of sensory hair cells in zebrafish. Developmental Biology. 272(2):328-338
Nicolson, T., Ernest, S., Rauch, J., Petit, C., Söllner, C., Seiler, C., and Busch, E. (2000) Isolation of the genes responsible for hearing disorders in zebrafish. The European journal of neuroscience. 12:316