ZFIN ID: ZDB-LAB-971216-15
Prince Lab
PI/Director: Prince, Victoria E.
Contact Person: Prince, Victoria E.
Email: vprince@uchicago.edu
URL: http://princelab-sites.uchicago.edu/
Address: Department of Organismal Biology and Anatomy Division of Biological Sciences University of Chicago 1027 East 57th Street Chicago, IL 60637 USA
Country: United States
Phone: (773) 834-2100
Fax: (773) 702-0037
Line Designation: ch

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Our research focuses on how the developing vertebrate body is patterned along the primary (anteroposterior; AP) body axis. We make use of a combination of molecular, cellular and embryological techniques to address how specific regions of the body are patterned. Our hindbrain work has led us to an ongoing investigation of the molecular and cellular mechanisms that control tangential migration of the facial branchiomotor neurons. We are also investigating neural crest migration and regionalization.

Beiriger, Anastasia Graduate Student Kushkowski, Elaine Graduate Student Rocha, Manuel

Alhashem, Z., Feldner-Busztin, D., Revell, C., Alvarez-Garcillan Portillo, M., Camargo-Sosa, K., Richardson, J., Rocha, M., Gauert, A., Corbeaux, T., Milanetto, M., Argenton, F., Tiso, N., Kelsh, R., Prince, V.E., Bentley, K., Linker, C. (2022) Notch controls the cell cycle to define leader versus follower identities during collective cell migration. eLIFE. 11:
Rocha, M., Kushkowski, E., Schnirman, R., Booth, C., Singh, N., Beadell, A., Prince, V.E. (2021) Zebrafish Cdx4 regulates neural crest cell specification and migratory behaviors in the posterior body. Developmental Biology. 480:25-38
Dalgin, G., Prince, V.E. (2020) Midline morphogenesis of zebrafish foregut endoderm is dependent on Hoxb5b. Developmental Biology. 471:1-9
Guo, M., Li, Y., Su, Y., Lambert, T., Nogare, D.D., Moyle, M.W., Duncan, L.H., Ikegami, R., Santella, A., Rey-Suarez, I., Green, D., Beiriger, A., Chen, J., Vishwasrao, H., Ganesan, S., Prince, V., Waters, J.C., Annunziata, C.M., Hafner, M., Mohler, W.A., Chitnis, A.B., Upadhyaya, A., Usdin, T.B., Bao, Z., Colón-Ramos, D., La Riviere, P., Liu, H., Wu, Y., Shroff, H. (2020) Rapid image deconvolution and multiview fusion for optical microscopy. Nature Biotechnology. 38:1337-1346
Beiriger, A., Narayan, S., Singh, N., Prince, V. (2020) Development and migration of the zebrafish rhombencephalic octavolateral efferent neurons. The Journal of comparative neurology. 529(7):1293-1307
Rocha, M., Singh, N., Ahsan, K., Beiriger, A., Prince, V.E. (2019) Neural crest development: Insights from the zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 249(1):88-111
Ahsan, K., Singh, N., Rocha, M., Huang, C., Prince, V.E. (2019) Prickle1 is required for EMT and migration of zebrafish cranial neural crest. Developmental Biology. 448(1):16-35
Prince, V.E., Anderson, R.M., Dalgin, G. (2017) Zebrafish Pancreas Development and Regeneration: Fishing for Diabetes Therapies. Current topics in developmental biology. 124:235-276
Dalgin, G., Prince, V.E. (2015) Differential levels of Neurod establish zebrafish endocrine pancreas cell fates. Developmental Biology. 402(1):81-97
Love, C.E., Prince, V.E. (2015) Rest represses maturation within migrating facial branchiomotor neurons. Developmental Biology. 401(2):220-35
Wanner, S.J., Saeger, I., Guthrie, S., and Prince, V.E. (2013) Facial motor neuron migration advances. Current opinion in neurobiology. 23(6):943-50
Eames, S.C., Kinkel, M.D., Rajan, S., Prince, V.E., Philipson, L.H. (2013) Transgenic zebrafish model of the C43G human insulin gene mutation. Journal of diabetes investigation. 4:157-67
Wanner, S.J., and Prince, V.E. (2013) Axon tracts guide zebrafish facial branchiomotor neuron migration through the hindbrain. Development (Cambridge, England). 140(4):906-915
Kok, F.O., Taibi, A., Wanner, S.J., Xie, X., Moravec, C.E., Love, C.E., Prince, V.E., Mumm, J.S., and Sirotkin, H.I. (2012) Zebrafish rest regulates developmental gene expression but not neurogenesis. Development (Cambridge, England). 139(20):3838-3848
Love, C.E., and Prince, V.E. (2012) Expression and retinoic acid regulation of the zebrafish nr2f orphan nuclear receptor genes. Developmental dynamics : an official publication of the American Association of Anatomists. 241(10):1603-1615
Dalgin, G., and Prince, V.E. (2012) Mnx1: A gatekeeper of beta cell fate. Islets. 4(4):320-322
Dalgin, G., Ward, A.B., Hao le, T., Beattie, C.E., Nechiporuk, A., and Prince, V.E. (2011) Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreas. Development (Cambridge, England). 138(21):4597-4608
Mapp, O.M., Walsh, G.S., Moens, C.B., Tada, M., and Prince, V.E. (2011) Zebrafish Prickle1b mediates facial branchiomotor neuron migration via a farnesylation-dependent nuclear activity. Development (Cambridge, England). 138(10):2121-2132
Kinkel, M.D., Eames, S.C., Philipson, L.H., and Prince, V.E. (2010) Intraperitoneal injection into adult zebrafish. Journal of visualized experiments : JoVE. (42)
Eames, S.C., Philipson, L.H., Prince, V.E., and Kinkel, M.D. (2010) Blood sugar measurement in zebrafish reveals dynamics of glucose homeostasis. Zebrafish. 7(2):205-213
Bingham, S.M., Sittaramane, V., Mapp, O., Patil, S., Prince, V.E., and Chandrasekhar, A. (2010) Multiple mechanisms mediate motor neuron migration in the zebrafish hindbrain. Developmental Neurobiology. 70(2):87-99
Elsen, G.E., Choi, L.Y., Prince, V.E., and Ho, R.K. (2009) The autism susceptibility gene met regulates zebrafish cerebellar development and facial motor neuron migration. Developmental Biology. 335(1):78-92
Kinkel, M.D., Sefton, E.M., Kikuchi, Y., Mizoguchi, T., Ward, A.B., and Prince, V.E. (2009) Cyp26 enzymes function in endoderm to regulate pancreatic field size. Proceedings of the National Academy of Sciences of the United States of America. 106(19):7864-7869
Kinkel, M.D., and Prince, V.E. (2009) On the diabetic menu: Zebrafish as a model for pancreas development and function. BioEssays : news and reviews in molecular, cellular and developmental biology. 31(2):139-152
Skromne, I., and Prince, V.E. (2008) Current perspectives in zebrafish reverse genetics: Moving forward. Developmental dynamics : an official publication of the American Association of Anatomists. 237(4):861-862
Kinkel, M.D., Eames, S.C., Alonzo, M.R., and Prince, V.E. (2008) Cdx4 is required in the endoderm to localize the pancreas and limit {beta}-cell number. Development (Cambridge, England). 135(5):919-929
Elsen, G.E., Choi, L.Y., Millen, K.J., Grinblat, Y., and Prince, V.E. (2008) Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesis. Developmental Biology. 314(2):376-392
Hurley, I.A., Scemama, J.L., and Prince, V.E. (2007) Consequences of Hoxb1 duplication in teleost fish. Evolution & development. 9(6):540-554
Rohrschneider, M.R., Elsen, G.E., and Prince, V.E. (2007) Zebrafish Hoxb1a regulates multiple downstream genes including prickle1b. Developmental Biology. 309(2):358-372
Skromne, I., Thorsen, D., Hale, M., Prince, V.E., and Ho, R.K. (2007) Repression of the hindbrain developmental program by Cdx factors is required for the specification of the vertebrate spinal cord. Development (Cambridge, England). 134(11):2147-2158
Ward, A.B., Warga, R.M., and Prince, V.E. (2007) Origin of the zebrafish endocrine and exocrine pancreas. Developmental dynamics : an official publication of the American Association of Anatomists. 236(6):1558-1569
Hadrys, T., Punnamoottil, B., Pieper, M., Kikuta, H., Pezeron, G., Becker, T.S., Prince, V., Baker, R., and Rinkwitz, S. (2006) Conserved co-regulation and promoter sharing of hoxb3a and hoxb4a in zebrafish. Developmental Biology. 297(1):26-43
Stafford, D., White, R.J., Kinkel, M.D., Linville, A., Schilling, T.F., and Prince, V.E. (2006) Retinoids signal directly to zebrafish endoderm to specify insulin-expressing {beta}-cells. Development (Cambridge, England). 133(5):949-956
Hogan, B.M., Hunter, M.P., Oates, A.C., Crowhurst, M.O., Hall, N.E., Heath, J.K., Prince, V.E., and Lieschke, G.J. (2004) Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm. Developmental Biology. 276(2):508-522
Hale, M.E., Kheirbek, M.A., Schriefer, J.E., and Prince, V.E. (2004) Hox gene misexpression and cell-specific lesions reveal functionality of homeotically transformed neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(12):3070-3076
Hadrys, T., Prince, V., Hunter, M., Baker, R., and Rinkwitz, S. (2004) Comparative genomic analysis of vertebrate Hox3 and Hox4 genes. The Journal of experimental zoology. 302(2):147-164
McClintock, J.M., Jozefowicz, C., Assimacopoulos, S., Grove, E.A., Louvi, A., and Prince, V.E. (2003) Conserved expression of Hoxa1 in neurons at the ventral forebrain/midbrain boundary of vertebrates. Development genes and evolution. 213(8):399-406
Jozefowicz, C., McClintock, J., and Prince, V. (2003) The fates of zebrafish Hox gene duplicates. Journal of structural and functional genomics. 3(1-4):185-194
Prince, V.E., and Pickett, F.B. (2002) Splitting pairs: the diverging fates of duplicated genes. Nature reviews. Genetics. 3(11):827-837
Scemama, J.L., Hunter, M., McCallum, J., Prince, V., and Stellwag, E. (2002) Evolutionary divergence of vertebrate Hoxb2 expression patterns and transcriptional regulatory loci. The Journal of experimental zoology. 294(3):285-299
Prince, V. (2002) The hox paradox: more complex(es) than imagined. Developmental Biology. 249(1):1-15
Stafford, D. and Prince, V.E. (2002) Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development. Current biology : CB. 12(14):1215-1220
Hunter, M. and Prince, V. (2002) Functions of zebrafish Hox paralog group 2 and 3 genes in hindbrain and pharyngeal arch development. Developmental Biology. 247(2):495
Hunter, M.P. and Prince, V.E. (2002) Zebrafish Hox paralogue group 2 genes function redundantly as selector genes to pattern the second pharyngeal arch. Developmental Biology. 247(2):367-389
McClintock, J.M., Kheirbek, M.A., and Prince, V.E. (2002) Knockdown of duplicated zebrafish hoxb1 genes reveals distinct roles in hindbrain patterning and a novel mechanism of duplicate gene retention. Development (Cambridge, England). 129(10):2339-2354
Moens, C.B. and Prince, V.E. (2002) Constructing the hindbrain: Insights from the zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 224(1):1-17
Hauptmann, G., Belting, H.-G., Wolke, U., Lunde, K., Söll, I., Abdelilah-Seyfried, S., Prince, V., and Driever, W. (2002) spiel ohne grenzen/pou2 is required for zebrafish hindbrain segmentation. Development (Cambridge, England). 129(7):1645-1655
McClintock, J.M., Carlson, R., Mann, D.M., and Prince, V.E. (2001) Consequences of Hox gene duplication in the vertebrates: an investigation of the zebrafish Hox paralogue group 1 genes. Development (Cambridge, England). 128(13):2471-2484
Prince, V.E., Holley, S.A., Bally-Cuif, L., Prabhakaran, B., Oates, A.C., Ho, R.K., and Vogt, T.F. (2001) Zebrafish lunatic fringe demarcates segmental boundaries. Mechanisms of Development. 105(1-2):175-180
Bruce, A.E., Oates, A.C., Prince, V.E., and Ho, R.K. (2001) Additional hox clusters in the zebrafish: divergent expression patterns belie equivalent activities of duplicate hoxB5 genes. Evolution & development. 3(3):127-144
Zerucha, T. and Prince, V.E. (2001) Cloning and developmental expression of a zebrafish meis2 homeobox gene. Mechanisms of Development. 102(1-2):247-250
Schilling, T.F., Prince, V., and Ingham, P.W. (2001) Plasticity in zebrafish hox expression in the hindbrain and cranial neural crest. Developmental Biology. 229:201-216
Roy, M.N., Prince, V.E., and Ho, R.K. (1999) Heat shock produces periodic somitic disturbances in the zebrafish embryo. Mechanisms of Development. 85(1-2):27-34
Bruce, A.E.E., Prince, V.E., and Ho, R.K. (1999) Comparison of expression and function of two hoxb5 paralogues in the zebrafish. Developmental Biology. 210:188
Amores, A., Force, A., Yan, Y.-L. Joly, L., Amemiya, C., Fritz, A., Ho, R., Langeland, J., Prince, V., Wang, Y.-L., Westerfield, M., Ekker, M., and Postlethwait, J.H. (1998) Zebrafish hox clusters and vertebrate genome evolution. Science (New York, N.Y.). 282:1711-1714
Prince, V.E., Price, A.L., and Ho, R.K. (1998) Hox gene expression reveals regionalization along the anteroposterior axis of the zebrafish notochord. Development genes and evolution. 208:517-522
Prince, V.E., Joly, L., Ekker, M., and Ho, R.K. (1998) Zebrafish hox genes: genomic organization and modified colinear expression patterns in the trunk. Development (Cambridge, England). 125:407-420
Prince, V.E., Moens, C.B., Kimmel, C.B., and Ho, R.K. (1998) Zebrafish hox genes: expression in the hindbrain region of wild-type and mutants of the segmentation gene valentino. Development (Cambridge, England). 125:393-406