ZFIN ID: ZDB-LAB-970512-1
University of Notre Dame Center for Zebrafish Research
PI/Director: Hyde, David R.
Co-PI / Senior
Vihtelic, Thomas
Contact Person: Vihtelic, Thomas
Address: Department of Biological Sciences University of Notre Dame 107 Galvin Life Science Center Notre Dame, IN 46556 USA
Country: United States
Phone: (574) 631-8641
Fax: (574) 631-7413
Line Designation: nt

Show all 25 genomic features

Zebrafish retina and lens molecular genetics.

Bailey, Travis Post-Doc Kassen, Sean Post-Doc Conner, Clay Graduate Student
Gorsuch, Ryne Graduate Student Harding, Rachel Graduate Student Montgomery, Jacob Graduate Student
Murphy, Taylor Graduate Student Nelson, Craig Graduate Student Raycroft, Fran Graduate Student
Bang, Debbie Fish Facility Staff Heed, Karen Fish Facility Staff Raje, Stacey Fish Facility Staff
Guzicki, Suzyanne Technical Staff

Silva, N.J., Nagashima, M., Li, J., Kakuk-Atkins, L., Ashrafzadeh, M., Hyde, D.R., Hitchcock, P.F. (2020) Inflammation and matrix metalloproteinase 9 (Mmp-9) regulate photoreceptor regeneration in adult zebrafish. Glia. 68(7):1445-1465
Iribarne, M., Hyde, D.R., Masai, I. (2019) TNFα Induces Müller Glia to Transition From Non-proliferative Gliosis to a Regenerative Response in Mutant Zebrafish Presenting Chronic Photoreceptor Degeneration. Frontiers in cell and developmental biology. 7:296
Wahlstrom-Helgren, S., Montgomery, J.E., Vanpelt, K.T., Biltz, S.L., Peck, J.H., Masino, M.A. (2019) Glutamate receptor subtypes differentially contribute to optogenetically-activated swimming in spinally-transected zebrafish larvae. Journal of neurophysiology. 122(6):2414-2426
Nelson, C.M., Lennon, V.A., Lee, H., Krug, R.G., Kamalova, A., Madigan, N.N., Clark, K.J., Windebank, A.J., Henley, J.R. (2019) Glucocorticoids Target Ependymal Glia and Inhibit Repair of the Injured Spinal Cord. Frontiers in cell and developmental biology. 7:56
Lahne, M., Piekos, S.M., O'Neill, J., Ackerman, K.M., Hyde, D.R. (2018) Photo-regulation of rod precursor cell proliferation. Experimental Eye Research. 178:148-159
Montgomery, J.E., Wahlstrom-Helgren, S., Wiggin, T.D., Corwin, B.M., Lillesaar, C., Masino, M.A. (2018) Intraspinal serotonergic signaling suppresses locomotor activity in larval zebrafish. Developmental Neurobiology.
Tye, M.T., Montgomery, J.E., Hobbs, M.R., Vanpelt, K.T., Masino, M.A. (2018) An Adult Zebrafish Diet Contaminated with Chromium Reduces the Viability of Progeny. Zebrafish. 15(2):179-187
Campbell, L.J., Hyde, D.R. (2017) Opportunities for CRISPR/Cas9 Gene Editing in Retinal Regeneration Research. Frontiers in cell and developmental biology. 5:99
Gorsuch, R.A., Lahne, M., Yarka, C.E., Petravick, M.E., Li, J., Hyde, D.R. (2017) Sox2 regulates Müller glia reprogramming and proliferation in the regenerating zebrafish retina via Lin28 and Ascl1a. Experimental Eye Research. 161:174-192
Lahne, M., Hyde, D.R. (2017) Live-cell imaging: new avenues to investigate retinal regeneration. Neural regeneration research. 12:1210-1219
Lahne, M., Gorsuch, R.A., Nelson, C.M., Hyde, D.R. (2017) Culture of Adult Transgenic Zebrafish Retinal Explants for Live-cell Imaging by Multiphoton Microscopy. Journal of visualized experiments : JoVE. (120)
Montgomery, J.E., Wiggin, T.D., Rivera-Perez, L.M., Lillesaar, C., Masino, M.A. (2016) Intraspinal serotonergic neurons consist of two, temporally distinct populations in developing zebrafish. Developmental Neurobiology. 76(6):673-87
Houbrechts, A.M., Vergauwen, L., Bagci, E., Van Houcke, J., Heijlen, M., Kulemeka, B., Hyde, D.R., Knapen, D., Darras, V.M. (2016) Deiodinase knockdown affects zebrafish eye development at the level of gene expression, morphology and function. Molecular and Cellular Endocrinology. 424:81-93
Lahne, M., Hyde, D.R. (2016) Interkinetic Nuclear Migration in the Regenerating Retina. Advances in experimental medicine and biology. 854:587-93
Lahne, M., Li, J., Marton, R.M., Hyde, D.R. (2015) Actin-Cytoskeleton- and Rock-Mediated INM Are Required for Photoreceptor Regeneration in the Adult Zebrafish Retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:15612-34
Rajaram, K., Harding, R.L., Bailey, T., Patton, J.G., Hyde, D.R. (2014) Dynamic miRNA Expression Patterns During Retina Regeneration in Zebrafish: Reduced Dicer or miRNA Expression Suppresses Proliferation of Müller Glia-Derived Neuronal Progenitor Cells. Developmental dynamics : an official publication of the American Association of Anatomists. 243(12):1591-605
Conner, C., Ackerman, K.M., Lahne, M., Hobgood, J.S., Hyde, D.R. (2014) Repressing Notch Signaling and Expressing TNFα Are Sufficient to Mimic Retinal Regeneration by Inducing Müller Glial Proliferation to Generate Committed Progenitor Cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(43):14403-19
Rajaram, K., Harding, R., Hyde, D.R., Patton, J.G. (2014) miR-203 regulates progenitor cell proliferation during adult zebrafish retina regeneration. Developmental Biology. 392(2):393-403
Gorsuch, R.A., and Hyde, D.R. (2014) Regulation of Müller glial dependent neuronal regeneration in the damaged adult zebrafish retina. Experimental Eye Research. 123:131-40
Hyde, D.R., Reh, T.A. (2014) The past, present, and future of retinal regeneration. Experimental Eye Research. 123:105-6
Sun, L., Li, P., Carr, A.L., Gorsuch, R., Yarka, C., Li, J., Bartlett, M., Pfister, D., Hyde, D.R., and Li, L. (2014) Transcription of the SCL/TAL1 interrupting locus (Stil) is required for cell proliferation in adult zebrafish retinas. The Journal of biological chemistry. 289(10):6934-40
Bailey, T.J., Hyde, D.R. (2014) The Phenotype of the Good Effort Mutant Zebrafish is Retinal Degeneration by Cell Death and is Linked to the Chromosome Assembly Factor 1b Gene. Advances in experimental medicine and biology. 801:535-41
Gemberling, M., Bailey, T.J., Hyde, D.R., and Poss, K.D. (2013) The zebrafish as a model for complex tissue regeneration. Trends in genetics : TIG. 29(11):611-20
Nelson, C.M., Ackerman, K.M., O'Hayer, P., Bailey, T.J., Gorsuch, R.A., and Hyde, D.R. (2013) Tumor Necrosis Factor-Alpha Is Produced by Dying Retinal Neurons and Is Required for Muller Glia Proliferation during Zebrafish Retinal Regeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(15):6524-6539
Nelson, C.M., Gorsuch, R.A., Bailey, T.J., Ackerman, K.M., Kassen, S.C., and Hyde, D.R. (2012) Stat3 defines three populations of Müller glia and is required for initiating maximal Müller glia proliferation in the regenerating zebrafish retina. The Journal of comparative neurology. 520(18):4294-4311
Bailey, T.J., Davis, D.H., Vance, J.E., and Hyde, D.R. (2012) Spectral-Domain Optical Coherence Tomography as a Noninvasive Method to Assess Damaged and Regenerating Adult Zebrafish Retinas. Investigative ophthalmology & visual science. 53(6):3126-3138
Thomas, J.L., Nelson, C.M., Luo, X., Hyde, D.R., and Thummel, R. (2012) Characterization of multiple light damage paradigms reveals regional differences in photoreceptor loss. Experimental Eye Research. 97(1):105-116
Hyde, D.R., Godwin, A.R., and Thummel, R. (2012) In vivo Electroporation of Morpholinos into the Regenerating Adult Zebrafish Tail Fin. Journal of visualized experiments : JoVE. (61)
Li, X., Montgomery, J., Cheng, W., Noh, J.H., Hyde, D.R., and Li, L. (2012) Pineal photoreceptor cells are required for maintaining the circadian rhythms of behavioral visual sensitivity in zebrafish. PLoS One. 7(7):e40508
Nelson, C.M., and Hyde, D.R. (2012) Müller glia as a source of neuronal progenitor cells to regenerate the damaged zebrafish retina. Advances in experimental medicine and biology. 723:425-430
Yin, J., Shine, L., Raycroft, F., Deeti, S., Reynolds, A., Ackerman, K.M., Glaviano, A., O'Farrell, S., O'Leary, O., Kilty, C., Kennedy, C., McLoughlin, S., Rice, M., Russell, E., Higgins, D.G., Hyde, D.R., and Kennedy, B.N. (2012) Inhibition of the pim1 oncogene results in diminished visual function. PLoS One. 7(12):e52177
Thummel, R., Bailey, T.J., and Hyde, D.R. (2011) In vivo Electroporation of Morpholinos into the Adult Zebrafish Retina. Journal of visualized experiments : JoVE. (58):e3603
Qin, Z., Kidd, A.R., Thomas, J.L., Poss, K.D., Hyde, D.R., Raymond, P.A., and Thummel, R. (2011) FGF signaling regulates rod photoreceptor cell maintenance and regeneration in zebrafish. Experimental Eye Research. 93(5):726-34
Murphy, T.R., Vihtelic, T.S., Ile, K.E., Watson, C.T., Willer, G.B., Gregg, R.G., Bankaitis, V.A., and Hyde, D.R. (2011) Phosphatidylinositol synthase is required for lens structural integrity and photoreceptor cell survival in the zebrafish eye. Experimental Eye Research. 93(4):460-74
Thomas, J.L., Vihtelic, T.S., Dendekker, A.D., Willer, G., Luo, X., Murphy, T.R., Gregg, R.G., Hyde, D.R., and Thummel, R. (2011) The loss of vacuolar protein sorting 11 (vps11) causes retinal pathogenesis in a vertebrate model of syndromic albinism. Investigative ophthalmology & visual science. 52(6):3119-28
Bailey, T.J., Fossum, S.L., Fimbel, S.M., Montgomery, J.E., and Hyde, D.R. (2010) The inhibitor of phagocytosis, O-phospho-L-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina. Experimental Eye Research. 91(5):601-612
Ile, K.E., Kassen, S., Cao, C., Vihtehlic, T., Shah, S.D., Mousley, C.J., Alb, J.G. Jr, Huijbregts, R.P., Stearns, G.W., Brockerhoff, S.E., Hyde, D.R., and Bankaitis, V.A. (2010) Zebrafish Class 1 Phosphatidylinositol Transfer Proteins: PITPbeta and Double Cone Cell Outer Segment Integrity in Retina. Traffic (Copenhagen, Denmark). 11(9):1151-1167
Thummel, R., Enright, J.M., Kassen, S.C., Montgomery, J.E., Bailey, T.J., and Hyde, D.R. (2010) Pax6a and Pax6b are required at different points in neuronal progenitor cell proliferation during zebrafish photoreceptor regeneration. Experimental Eye Research. 90(5):572-582
Montgomery, J.E., Parsons, M.J., and Hyde, D.R. (2010) A novel model of retinal ablation demonstrates that the extent of rod cell death regulates the origin of the regenerated zebrafish rod photoreceptors. The Journal of comparative neurology. 518(6):800-814
Yang, X., Zou, J., Hyde, D.R., Davidson, L.A., and Wei, X. (2009) Stepwise maturation of apicobasal polarity of the neuroepithelium is essential for vertebrate neurulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(37):11426-11440
Kassen, S.C., Thummel, R., Campochiaro, L.A., Harding, M.J., Bennett, N.A., and Hyde, D.R. (2009) CNTF induces photoreceptor neuroprotection and Müller glial cell proliferation through two different signaling pathways in the adult zebrafish retina. Experimental Eye Research. 88(6):1051-1064
Calinescu, A.A., Vihtelic, T.S., Hyde, D.R., and Hitchcock, P.F. (2009) Cellular expression of Midkine-a and Midkine-b during retinal development and photoreceptor regeneration in zebrafish. The Journal of comparative neurology. 514(1):1-10
Thummel, R., Kassen, S.C., Enright, J.M., Nelson, C.M., Montgomery, J.E., and Hyde, D.R. (2008) Characterization of Müller glia and neuronal progenitors during adult zebrafish retinal regeneration. Experimental Eye Research. 87(5):433-444
Stenkamp, D.L., Satterfield, R., Muhunthan, K., Sherpa, T., Vihtelic, T.S., and Cameron, D. (2008) Age-Related Cone Abnormalities in Zebrafish with Genetic Lesions in Sonic Hedgehog. Investigative ophthalmology & visual science. 49(10):4631-4640
Barresi, M.J., Farber, S.A., Hutson, L.D., Hyde, D.R., Liang, J.O., and Morris, J.K. (2008) Zebrafish in the Classroom. Zebrafish. 5(3):205-208
Kassen, S.C., Thummel, R., Burket, C.T., Campochiaro, L.A., Harding, M.J., and Hyde, D.R. (2008) The Tg(ccnb1:EGFP) transgenic zebrafish line labels proliferating cells during retinal development and regeneration. Molecular Vision. 14:951-963
Hoptak-Solga, A.D., Nielsen, S., Jain, I., Thummel, R., Hyde, D.R., and Iovine, M.K. (2008) Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration. Developmental Biology. 317(2):541-548
Harding, R.L., Howley, S., Baker, L.J., Murphy, T.R., Archer, W.E., Wistow, G., Hyde, D.R., and Vihtelic, T.S. (2008) Lengsin expression and function during zebrafish lens formation. Experimental Eye Research. 86(5):807-818
Burket, C.T., Montgomery, J.E., Thummel, R., Kassen, S.C., Lafave, M.C., Langenau, D.M., Zon, L.I., and Hyde, D.R. (2008) Generation and characterization of transgenic zebrafish lines using different ubiquitous promoters. Transgenic Research. 17(2):265-279
Yin, V.P., Thomson, J.M., Thummel, R., Hyde, D.R., Hammond, S.M., and Poss, K.D. (2008) Fgf-dependent depletion of microRNA-133 promotes appendage regeneration in zebrafish. Genes & Development. 22(6):728-733
Thummel, R., Kassen, S.C., Montgomery, J.E., Enright, J.M., and Hyde, D.R. (2008) Inhibition of Müller glial cell division blocks regeneration of the light-damaged zebrafish retina. Developmental Neurobiology. 68(3):392-408
Sherpa, T., Fimbel, S.M., Mallory, D.E., Maaswinkel, H., Spritzer, S.D., Sand, J.A., Li, L., Hyde, D.R., and Stenkamp, D.L. (2008) Ganglion cell regeneration following whole-retina destruction in zebrafish. Developmental Neurobiology. 68(2):166-181
Kassen, S. (2008) Characterization of light-induced zebrafish retinal regeneration and the role of Stat3, CNTF, and Olig2 during light-induced zebrafish retinal regeneration. Ph.D. Thesis. :222p
Vihtelic, T.S. (2008) Chapter 6 teleost lens development and degeneration. International review of cell and molecular biology. 269:341-373
Alvarez, Y., Cederlund, M.L., Cottell, D.C., Bill, B.R., Ekker, S.C., Torres-Vazquez, J., Weinstein, B.M., Hyde, D.R., Vihtelic, T.S., and Kennedy, B.N. (2007) Genetic determinants of hyaloid and retinal vasculature in zebrafish. BMC Developmental Biology. 7(1):114
Kassen, S.C., Ramanan, V., Montgomery, J.E., Burket, C.T., Liu, C.G., Vihtelic, T.S., and Hyde, D.R. (2007) Time course analysis of gene expression during light-induced photoreceptor cell death and regeneration in albino zebrafish. Developmental Neurobiology. 67(8):1009-1031
Tawk, M., Araya, C., Lyons, D.A., Reugels, A.M., Girdler, G.C., Bayley, P.R., Hyde, D.R., Tada, M., and Clarke, J.D. (2007) A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis. Nature. 446(7137):797-800
Yu, C.J., Gao, Y., Willis, C.L., Li, P., Tiano, J.P., Nakamura, P.A., Hyde, D.R., and Li, L. (2007) Mitogen-associated protein kinase- and protein kinase A-dependent regulation of rhodopsin promoter expression in zebrafish rod photoreceptor cells. Journal of neuroscience research. 85(3):488-496
Fimbel, S.M., Montgomery, J.E., Burket, C.T., and Hyde, D.R. (2007) Regeneration of inner retinal neurons after intravitreal injection of ouabain in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(7):1712-1724
Thummel, R., Burket, C.T., and Hyde, D.R. (2006) Two different transgenes to study gene silencing and re-expression during zebrafish caudal fin and retinal regeneration. TheScientificWorldJournal. 6(1):65-81
Semina, E.V., Bosenko, D.V., Zinkevich, N.C., Soules, K.A., Hyde, D.R., Vihtelic, T.S., Willer, G.B., Gregg, R.G., and Link, B.A. (2006) Mutations in laminin alpha 1 result in complex, lens-independent ocular phenotypes in zebrafish. Developmental Biology. 299(1):63-77
Shi, X., Luo, Y., Howley, S., Dzialo, A., Foley, S., Hyde, D.R., and Vihtelic, T.S. (2006) Zebrafish foxe3: Roles in ocular lens morphogenesis through interaction with pitx3. Mechanisms of Development. 123(10):761-782
Vihtelic, T.S., Soverly, J.E., Kassen, S.C., and Hyde, D.R. (2006) Retinal regional differences in photoreceptor cell death and regeneration in light-lesioned albino zebrafish. Experimental Eye Research. 82(4):558-575
Smith, A.A., Wyatt, K., Vacha, J., Vihtelic, T.S., Samuel Zigler, J. Jr, Wistow, G.J., and Posner, M. (2006) Gene duplication and separation of functions in alphaB-crystallin from zebrafish (Danio rerio). The FEBS journal. 273(3):481-490
Thummel, R., Bai, S., Sarras, M.P. Jr, Song, P., McDermott, J., Brewer, J., Perry, M., Zhang, X., Hyde, D.R., and Godwin, A.R. (2006) Inhibition of zebrafish fin regeneration using in vivo electroporation of morpholinos against fgfr1 and msxb. Developmental dynamics : an official publication of the American Association of Anatomists. 235(2):336-346
Wei, X., Luo, Y., and Hyde, D.R. (2006) Molecular cloning of three zebrafish lin7 genes and their expression patterns in the retina. Experimental Eye Research. 82(1):122-131
Vihtelic, T.S., Fadool, J.M., Gao, J., Thornton, K.A., Hyde, D.R., and Wistow, G. (2005) Expressed sequence tag analysis of zebrafish eye tissues for NEIBank. Molecular Vision. 11:1083-1100
Vihtelic, T.S., Yamamoto, Y., Springer, S.S., Jeffery, W.R., and Hyde, D.R. (2005) Lens opacity and photoreceptor degeneration in the zebrafish lens opaque mutant. Developmental dynamics : an official publication of the American Association of Anatomists. 233(1):52-65
Wistow, G., Wyatt, K., David, L., Gao, C., Bateman, O., Bernstein, S., Tomarev, S., Segovia, L., Slingsby, C., and Vihtelic, T. (2005) gammaN-crystallin and the evolution of the betagamma-crystallin superfamily in vertebrates. The FEBS journal. 272(9):2276-2291
Shi, X., Bosenko, D.V., Zinkevich, N.S., Foley, S., Hyde, D.R., Semina, E.V., and Vihtelic, T.S. (2005) Zebrafish pitx3 is necessary for normal lens and retinal development. Mechanisms of Development. 122(4):513-527
Wei, X., Cheng, Y., Luo, Y., Shi, X., Nelson, S., and Hyde, D.R. (2004) The zebrafish Pard3 ortholog is required for separation of the eye fields and retinal lamination. Developmental Biology. 269(1):286-301
Vihtelic, T.S. and Hyde, D.R. (2002) Zebrafish mutagenesis yields eye morphological mutants with retinal and lens defects. Vision Research. 42(4):535-540
Vihtelic, T.S., Yamamoto, Y., Sweeney, M.T., Jeffery, W.R., and Hyde, D.R. (2001) Arrested differentiation and epithelial cell degeneration in zebrafish lens mutants. Developmental dynamics : an official publication of the American Association of Anatomists. 222(4):625-636
Kennedy, B.N., Vihtelic, T.S., Checkley, L., Vaughan, K.T., and Hyde, D.R. (2001) Isolation of a zebrafish rod opsin promoter to generate a transgenic zebrafish line expressing EGFP in rod photoreceptors. The Journal of biological chemistry. 276(17):14037-14043
Vihtelic, T.S., Huijbregts, R.P., Watkins, W.A., Bankaitis, V.A., and Hyde, D.R. (2001) Identification and characterization of the zebrafish PITP beta: a protein expressed at high levels in the double cone cell synapse. Investigative ophthalmology & visual science. 42(4):1036
Vihtelic, T.S. and Hyde, D.R. (2000) Light-induced rod and cone cell death and regeneration in the adult albino zebrafish (Danio rerio) retina. Journal of neurobiology. 44(3):289-307
Elagin, V.A., Elagina, R.B., Doro, C.J., Vihtelic, T.S., and Hyde, D.R. (2000) Cloning and tissue localization of a novel zebrafish RdgB homolog that lacks a phospholipid transfer domain. Visual neuroscience. 17(2):303-311
Vihtelic, T.S., Doro, C.J., and Hyde, D.R. (1999) Cloning and characterization of six zebrafish photoreceptor opsin cDNAs and immunolocalization of their corresponding proteins. Visual neuroscience. 16:571-585
Nelson, C.E. and Tabin, C. (1995) Footnote on limb evolution. Nature 375:630-631. Comment on Nature. 375:678-681