The long-term goal of Dr. Zoidl’s research program is to understand the fundamental principles of electrical and metabolic coupling of nerve cells mediated by connexins and pannexins in health and disease. In order to accomplish this goal, the group exploits an interdisciplinary approach using a combination of state-of-the-art techniques including molecular and cell biology methodology, functional genomics and proteomics, various life cell imaging techniques (confocal, TIRF, FRAP, FRET), and electrophysiology (in vivo patch clamp) to characterize the molecular underpinnings of disease in vitro and in vivo. Our animal model of choice are transgenic and knock-out zebrafish, which we create in-house.