ZFIN ID: ZDB-LAB-180207-3
Qing Deng Lab
PI/Director: Deng, Qing
Contact Person: Deng, Qing
Email: qingdeng@purdue.edu
URL: http://https://www.bio.purdue.edu/lab/deng/
Address: Department of Biological Sciences Purdue University LILY G201 915 W. State Street West Lafayette, IN 47907
Country: United States
Phone: 765-496-3237
Fax: 765-494-0876
Line Designation: pu

Show all 13 genomic features

Our lab is interested in the mechanisms that regulate neutrophil migration and activation, more specifically their response to tissue injury and infection. The neutrophil is a hallmark of inflammation and neutrophilic inflammation is the driving force behind a spectrum of human inflammatory diseases. Restraining neutrophilic inflammation will help alleviate diseases such as arthritis, cancer and auto-inflammation. We are also interested in understanding pathogen-host interactions using the zebrafish model and the strength relies on the combination of the genetics in pathogens and the host. We are creating a lab where happy scientists do solid science.

One of our current projects is to characterize the role of miRNAs in regulating neutrophil functions. Using next generation sequencing, we have identified miRNAs that are enriched in neutrophils. The focus to characterize the contribution of each individual miRNA in regulating neutrophil motility and response to tissue injury or infection using a combination of genetics and imaging tools.

Gurol, Theodore Graduate Student Hsu, Alan Graduate Student Jeffries, Jacob Graduate Student
Wang, Tianqi Graduate Student Zhou, Wenqing Graduate Student

Weaver, C.J., Terzi, A., Roeder, H., Gurol, T., Deng, Q., Fai Leung, Y., Suter, D.M. (2018) nox2/cybb deficiency affects zebrafish retinotectal connectivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(26):5854-5871
Hsu, A.Y., Gurol, T., Sobreira, T.J.P., Zhang, S., Moore, N., Cai, C., Zhang, Z.Y., Deng, Q. (2018) Development and Characterization of an Endotoxemia Model in Zebra Fish. Frontiers in immunology. 9:607
Zhou, W., Cao, L., Jeffries, J., Zhu, X., Staiger, C.J., Deng, Q. (2018) Neutrophil-specific knockout demonstrates a role for mitochondria in regulating neutrophil motility in zebrafish. Disease models & mechanisms. 11(3)
Zhou, W., Pal, A.S., Hsu, A.Y., Gurol, T., Zhu, X., Wirbisky-Hershberger, S.E., Freeman, J.L., Kasinski, A.L., Deng, Q. (2018) MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation. Cell Reports. 22:1810-1823
Hsu, A.Y., Wang, D., Gurol, T., Zhou, W., Zhu, X., Lu, H.Y., Deng, Q. (2017) Overexpression of microRNA-722 fine-tunes neutrophilic inflammation by inhibiting Rac2 in zebrafish.. Disease models & mechanisms. 10(11):1323-1332
Powell, D., Tauzin, S., Hind, L.E., Deng, Q., Beebe, D.J., Huttenlocher, A. (2017) Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues. Cell Reports. 19:1572-1585