ZFIN ID: ZDB-PERS-180207-6
Deng, Qing
Email: deng67@purdue.edu
URL: https://www.bio.purdue.edu/People/faculty_dm/directory.php?refID=1000000169
Affiliation: Qing Deng Lab
Address: Department of Biological Sciences Purdue University LILY G201 915 W. State Street West Lafayette, IN 47907
Country: United States
Phone: 765-494-0423
Fax: 765-494-0876
ORCID ID: 0000-0002-9254-9951

We use the zebrafish model to discover novel regulators of neutrophil migration, inflammation and pathogen-host interaction. We also use human cell and mouse models to study related molecular mechanisms. Our goal is to discover novel biological regulations that can be used to control neutrophilic inflammation and many related diseases.

Chang, Y., Syahirah, R., Oprescu, S.N., Wang, X., Jung, J., Cooper, S.H., Torregrosa-Allen, S., Elzey, B.D., Hsu, A.Y., Randolph, L.N., Sun, Y., Kuang, S., Broxmeyer, H.E., Deng, Q., Lian, X., Bao, X. (2022) Chemically-defined generation of human hemogenic endothelium and definitive hematopoietic progenitor cells. Biomaterials. 285:121569
Hsu, A.Y., Wang, T., Syahirah, R., Liu, S., Li, K., Zhang, W., Wang, J., Cao, Z., Tian, S., Matosevic, S., Staiger, C.J., Wan, J., Deng, Q. (2022) Rora Regulates Neutrophil Migration and Activation in Zebrafish. Frontiers in immunology. 13:756034
Wang, Y., Hsu, A.Y., Walton, E.M., Park, S.J., Syahirah, R., Wang, T., Zhou, W., Ding, C., Lemke, A.P., Zhang, G., Tobin, D.M., Deng, Q. (2021) A robust and flexible CRISPR/Cas9 based system for neutrophil-specific gene inactivation in zebrafish. Journal of Cell Science. 134(8):
Zhou, W., Hsu, A.Y., Wang, Y., Syahirah, R., Wang, T., Jeffries, J., Wang, X., Mohammad, H., Seleem, M.N., Umulis, D., Deng, Q. (2020) Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton. Journal of Cell Science. 133(17):
Cash, J.N., Chandan, N.R., Hsu, A.Y., Sharma, P.V., Deng, Q., Smrcka, A.V., Tesmer, J.J.G. (2020) Discovery of small molecules that target the P-Rex1 PIP3-binding site and inhibit P-Rex1-dependent functions in neutrophils. Molecular pharmacology. 97(3):226-236
Hsu, A.Y., Wang, D., Liu, S., Lu, J., Syahirah, R., Bennin, D.A., Huttenlocher, A., Umulis, D.M., Wan, J., Deng, Q. (2019) Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration. Proceedings of the National Academy of Sciences of the United States of America. 116(37):18561-18570
Hsu, A.Y., Liu, S., Syahirah, R., Brasseale, K.A., Wan, J., Deng, Q. (2019) Inducible overexpression of zebrafish microRNA-722 suppresses chemotaxis of human neutrophil like cells. Molecular immunology. 112:206-214
Weaver, C.J., Terzi, A., Roeder, H., Gurol, T., Deng, Q., Fai Leung, Y., Suter, D.M. (2018) nox2/cybb deficiency affects zebrafish retinotectal connectivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(26):5854-5871
Hsu, A.Y., Gurol, T., Sobreira, T.J.P., Zhang, S., Moore, N., Cai, C., Zhang, Z.Y., Deng, Q. (2018) Development and Characterization of an Endotoxemia Model in Zebra Fish. Frontiers in immunology. 9:607
Zhou, W., Cao, L., Jeffries, J., Zhu, X., Staiger, C.J., Deng, Q. (2018) Neutrophil-specific knockout demonstrates a role for mitochondria in regulating neutrophil motility in zebrafish. Disease models & mechanisms. 11(3)
Zhou, W., Pal, A.S., Hsu, A.Y., Gurol, T., Zhu, X., Wirbisky-Hershberger, S.E., Freeman, J.L., Kasinski, A.L., Deng, Q. (2018) MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation. Cell Reports. 22:1810-1823
Hsu, A.Y., Wang, D., Gurol, T., Zhou, W., Zhu, X., Lu, H.Y., Deng, Q. (2017) Overexpression of microRNA-722 fine-tunes neutrophilic inflammation by inhibiting Rac2 in zebrafish.. Disease models & mechanisms. 10(11):1323-1332
Powell, D., Tauzin, S., Hind, L.E., Deng, Q., Beebe, D.J., Huttenlocher, A. (2017) Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues. Cell Reports. 19:1572-1585

Jeffries J, Zhou W, Hsu AY and Deng Q. microRNA-223 at the crossroads of inflammation and cancer. Cancer Lett. 2019 June; 451(1):136-141. Review
Gurol T, Zhou W, Deng Q. MicroRNAs in neutrophils: potential next generation therapeutics for inflammatory ailments. Immunol Rev. 2016 Sep;273(1):29-47. PMID: 27558326. Review