ZFIN ID: ZDB-LAB-151014-1
Mugen Liu Lab
PI/Director: Liu, Mugen
Contact Person: Liu, Mugen
Email: lium@hust.edu.cn
Address: Key Laboratory of Molecular Biophysics of Ministry of Education, Department of Genetics and Developmental Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China
Country: China
Phone: 86 27-87794549
Line Designation: hzu

Show all 21 genomic features

The main interests of the lab are to identify novel mutations and disease-causing genes of inherited ocular diseases (such as retinal degeneration, cataract), to study the functions of these causative genes in cultured cell lines, zebrafish or mouse models, and finally to reveal the pathogenesis of these diseases and develop potential therapies.

Li, Chang Post-Doc Liu, Fei Post-Doc Yu, Shanshan Post-Doc
Gao, Meng Graduate Student Han, Shanshan Graduate Student Hu, Xuebin Graduate Student
Huang, Yuwen Graduate Student Li, Jingzhen Graduate Student Liu, Xiliang Graduate Student
Lu, Zhaojing Graduate Student Ly, Yuexiang Graduate Student Qin, Yayun Graduate Student
Qu, Zhen Graduate Student Yang, Lifang Graduate Student

Lv, Y., Li, J., Yu, S., Zhang, Y., Hu, H., Sun, K., Jia, D., Han, Y., Tu, J., Huang, Y., Liu, X., Zhang, X., Gao, P., Chen, X., Shaw Williams, M.T., Tang, Z., Shu, X., Liu, M., Ren, X. (2024) The splicing factor Prpf31 is required for hematopoietic stem and progenitor cell expansion during zebrafish embryogenesis. The Journal of biological chemistry. 300(3):105772
Han, S., Hu, Y., Jia, D., Lv, Y., Liu, M., Wang, D., Chao, J., Xia, X., Wang, Q., Liu, P., Cai, Y., Ren, X. (2024) IFT27 regulates the long-term maintenance of photoreceptor outer segments in zebrafish. Gene. 905:148237
Jing, Y., Luo, Y., Li, L., Liu, M., Liu, J.X. (2024) Deficiency of copper responsive gene stmn4 induces retinal developmental defects. Cell biology and toxicology. 40:22
Sun, K., Han, Y., Li, J., Yu, S., Huang, Y., Zhang, Y., Reilly, J., Tu, J., Gao, P., Jia, D., Chen, X., Hu, H., Ren, M., Li, P., Luo, J., Ren, X., Zhang, X., Shu, X., Liu, F., Liu, M., Tang, Z. (2023) The splicing factor DHX38 enables retinal development through safeguarding genome integrity. iScience. 26:108103108103
Liu, X., Han, S., Liu, F., Yu, S., Qin, Y., Li, J., Jia, D., Gao, P., Chen, X., Tang, Z., Liu, M., Huang, Y. (2023) Retinal degeneration in rpgra mutant zebrafish. Frontiers in cell and developmental biology. 11:11699411169941
Jia, D., Gao, P., Lv, Y., Huang, Y., Reilly, J., Sun, K., Han, Y., Hu, H., Chen, X., Zhang, Z., Li, P., Luo, J., Shu, X., Tang, Z., Liu, F., Liu, M., Ren, X. (2022) Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish. Cell Death & Disease. 13:962
Tu, J., Yu, S., Li, J., Ren, M., Zhang, Y., Luo, J., Sun, K., Lv, Y., Han, Y., Huang, Y., Ren, X., Jiang, T., Tang, Z., Williams, M.T.S., Lu, Q., Liu, M. (2022) Dhx38 regulates the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Development (Cambridge, England). 149(17)
Zhao, G., Hu, J., Gao, M., Zhu, Y., Hong, Y. (2022) Excessive selenium affects neural development and locomotor behavior of zebrafish embryos. Ecotoxicology and environmental safety. 238:113611
Gao, P., Jia, D., Li, P., Huang, Y., Hu, H., Sun, K., Lv, Y., Chen, X., Han, Y., Zhang, Z., Ren, X., Wang, Q., Liu, F., Tang, Z., Liu, M. (2022) Accumulation of Lipid Droplets in a Novel Bietti Crystalline Dystrophy Zebrafish Model With Impaired PPARα Pathway. Investigative ophthalmology & visual science. 63:32
Gao, M., Hu, J., Zhu, Y., Wang, X., Zeng, S., Hong, Y., Zhao, G. (2022) Ferroptosis and Apoptosis Are Involved in the Formation of L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos. International Journal of Molecular Sciences. 23(9)
Liu, F., Qin, Y., Huang, Y., Gao, P., Li, J., Yu, S., Jia, D., Chen, X., Lv, Y., Tu, J., Sun, K., Han, Y., Reilly, J., Shu, X., Lu, Q., Tang, Z., Xu, C., Luo, D., Liu, M. (2022) Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration. PLoS Genetics. 18:e1009841
Chen, X., Huang, Y., Gao, P., Lv, Y., Jia, D., Sun, K., Han, Y., Hu, H., Tang, Z., Ren, X., Liu, M. (2021) Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells. Biomedicines. 9(11):
Li, J., Liu, F., Lv, Y., Sun, K., Zhao, Y., Reilly, J., Zhang, Y., Tu, J., Yu, S., Liu, X., Qin, Y., Huang, Y., Gao, P., Jia, D., Chen, X., Han, Y., Shu, X., Luo, D., Tang, Z., Liu, M. (2021) Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing. Nucleic acids research. 49(4):2027-2043
Tu, J., Liu, X., Jia, H., Reilly, J., Yu, S., Cai, C., Liu, F., Lv, Y., Huang, Y., Lu, Z., Han, S., Jiang, T., Shu, X., Wu, X., Tang, Z., Lu, Q., Liu, M. (2020) The chromatin remodeler Brg1 is required for formation and maintenance of hematopoietic stem cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(9):11997-12008
Zhang, J., Cui, W.W., Du, C., Huang, Y., Pi, X., Guo, W., Wang, J., Huang, W., Chen, D., Li, J., Li, H., Zhang, J., Ma, Y., Mu, H., Zhang, S., Liu, M., Cui, X., Hu, Y. (2020) Knockout of DNase1l1l abrogates lens denucleation process and causes cataract in zebrafish. Biochimica et biophysica acta. Molecular basis of disease. 1866:165724
Ping, J., Zhao, F., Nie, J., Yu, T., Zhu, D., Liu, M., Fei, P. (2019) Propagating-path uniformly scanned light sheet excitation microscopy for isotropic volumetric imaging of large specimens. Journal of Biomedical Optics. 24:1-5
Lu, Z., Hu, X., Reilly, J., Jia, D., Liu, F., Yu, S., Liu, X., Xie, S., Qu, Z., Qin, Y., Huang, Y., Lv, Y., Li, J., Gao, P., Wong, F., Shu, X., Tang, Z., Liu, M. (2019) Deletion of the transmembrane protein Prom1b in zebrafish disrupts outer-segment morphogenesis and causes photoreceptor degeneration. The Journal of biological chemistry. 294(38):13953-13963
Qu, Z., Yimer, T.A., Xie, S., Wong, F., Yu, S., Liu, X., Han, S., Ma, J., Lu, Z., Hu, X., Qin, Y., Huang, Y., Lv, Y., Li, J., Tang, Z., Liu, F., Liu, M. (2019) Knocking out lca5 in zebrafish causes cone-rod dystrophy due to impaired outer segment protein trafficking. Biochimica et biophysica acta. Molecular basis of disease. 1865(10):2694-2705
Xie, S., Han, S., Qu, Z., Liu, F., Li, J., Yu, S., Reilly, J., Tu, J., Liu, X., Lu, Z., Hu, X., Yimer, T.A., Qin, Y., Huang, Y., Lv, Y., Jiang, T., Shu, X., Tang, Z., Jia, H., Wong, F., Liu, M. (2019) Knockout of Nr2e3 prevents rod photoreceptor differentiation and leads to selective L-/M-cone photoreceptor degeneration in zebrafish. Biochimica et biophysica acta. Molecular basis of disease. 1865(6):1273-1283
Yu, S., Jiang, T., Jia, D., Han, Y., Liu, F., Huang, Y., Qu, Z., Zhao, Y., Tu, J., Lv, Y., Li, J., Hu, X., Lu, Z., Han, S., Qin, Y., Liu, X., Xie, S., Wang, Q.K., Tang, Z., Luo, D., Liu, M. (2018) BCAS2 is essential for hematopoietic stem and progenitor cell maintenance during zebrafish embryogenesis. Blood. 133(8):805-815
Han, S., Liu, X., Xie, S., Gao, M., Liu, F., Yu, S., Sun, P., Wang, C., Archacki, S., Lu, Z., Hu, X., Qin, Y., Qu, Z., Huang, Y., Lv, Y., Tu, J., Li, J., Yimer, T.A., Jiang, T., Tang, Z., Luo, D., Chen, F., Liu, M. (2018) Knockout of ush2a gene in zebrafish causes hearing impairment and late onset rod-cone dystrophy. Human genetics. 137(10):779-794
Raghupathy, R.K., Zhang, X., Liu, F., Alhasani, R.H., Biswas, L., Akhtar, S., Pan, L., Moens, C.B., Li, W., Liu, M., Kennedy, B.N., Shu, X. (2017) Rpgrip1 is required for rod outer segment development and ciliary protein trafficking in zebrafish. Scientific Reports. 7:16881
Gao, M., Huang, Y., Wang, L., Huang, M., Liu, F., Liao, S., Yu, S., Lu, Z., Han, S., Hu, X., Qu, Z., Liu, X., Assefa Yimer, T., Yang, L., Tang, Z., Li, D.W., Liu, M. (2017) HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators. Cell Death & Disease. 8:e3082
Yu, S., Li, C., Biswas, L., Hu, X., Liu, F., Reilly, J., Liu, X., Liu, Y., Huang, Y., Lu, Z., Han, S., Wang, L., Liu, J.Y., Jiang, T., Shu, X., Wong, F., Tang, Z., Liu, M. (2017) CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish. Human molecular genetics. 26(12):2335-2345
Liu, F., Qin, Y., Yu, S., Soares, D.C., Yang, L., Weng, J., Li, C., Gao, M., Lu, Z., Hu, X., Liu, X., Jiang, T., Liu, J.Y., Shu, X., Tang, Z., Liu, M. (2017) Pathogenic Mutations in Retinitis Pigmentosa 2 Predominantly Result in Loss of RP2 Protein Stability in Human and Zebrafish. The Journal of biological chemistry. 292(15):6225-6239
Lu, Z., Hu, X., Liu, F., Soares, D.C., Liu, X., Yu, S., Gao, M., Han, S., Qin, Y., Li, C., Jiang, T., Luo, D., Guo, A.Y., Tang, Z., Liu, M. (2017) Ablation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophy. Scientific Reports. 7:46098
Zhang, B., Zheng, H., Huang, B., Li, W., Xiang, Y., Peng, X., Ming, J., Wu, X., Zhang, Y., Xu, Q., Liu, W., Kou, X., Zhao, Y., He, W., Li, C., Chen, B., Li, Y., Wang, Q., Ma, J., Yin, Q., Kee, K., Meng, A., Gao, S., Xu, F., Na, J., Xie, W. (2016) Allelic reprogramming of the histone modification H3K4me3 in early mammalian development. Nature. 537:553-557
Raghupathy, R.K., Zhang, X., Alhasani, R.H., Zhou, X., Mullin, M., Reilly, J., Li, W., Liu, M., Shu, X. (2016) Abnormal photoreceptor outer segment development and early retinal degeneration in kif3a mutant zebrafish. Cell biochemistry and function. 34(6):429-40
Gao, M., Zhang, S., Liu, C., Qin, Y., Archacki, S., Jin, L., Wang, Y., Liu, F., Chen, J., Liu, Y., Wang, J., Huang, M., Liao, S., Tang, Z., Guo, A.Y., Jiang, F., Liu, M. (2016) Whole exome sequencing identifies a novel NRL mutation in a Chinese family with autosomal dominant retinitis pigmentosa. Molecular Vision. 22:234-42
Liu, F., Chen, J., Yu, S., Raghupathy, R.K., Liu, X., Qin, Y., Li, C., Huang, M., Liao, S., Wang, J., Zou, J., Shu, X., Tang, Z., Liu, M. (2015) Knockout of RP2 decreases GRK1 and rod transducin subunits and leads to photoreceptor degeneration in zebrafish. Human molecular genetics. 24(16):4648-59
Dai, Z., Wang, H., Jin, X., Wang, H., He, J., Liu, M., Yin, Z., Sun, Y., Lou, Q. (2015) Depletion of suppressor of cytokine signaling-1a causes hepatic steatosis and insulin resistance in zebrafish. American journal of physiology. Endocrinology and metabolism. 308(10):E849-59
Li, C., Wang, L., Zhang, J., Huang, M., Wong, F., Liu, X., Liu, F., Cui, X., Yang, G., Chen, J., Liu, Y., Wang, J., Liao, S., Gao, M., Hu, X., Shu, X., Wang, Q., Yin, Z., Tang, Z., Liu, M. (2014) CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis. Biochimica et biophysica acta. Molecular basis of disease. 1842(7):1121-9
Zhang, J., Cui, X., Wang, L., Liu, F., Jiang, T., Li, C., Li, D., Huang, M., Liao, S., Wang, J., Chen, J., Jia, H., He, J., Tang, Z., Yin, Z., Liu, M. (2014) The Mitochondrial Thioredoxin is Required for Liver Development in Zebrafish. Current Molecular Medicine. 14(6):772-82
Cui, X., Wang, L., Zhang, J., Du, R., Liao, S., Li, D., Li, C., Ke, T., Li, D.W., Huang, H., Yin, Z., Tang, Z., and Liu, M. (2013) HSF4 regulates DLAD expression and promotes lens de-nucleation. Biochimica et biophysica acta. Molecular basis of disease. 1832(8):1167-72
Cui, X., Zhang, J., Du, R., Wang, L., Archacki, S., Zhang, Y., Yuan, M., Ke, T., Li, H., Li, D., Li, C., Li, D.W., Tang, Z., Yin, Z., and Liu, M. (2012) HSF4 is involved in DNA damage repair through regulation of Rad51. Biochimica et biophysica acta. Molecular basis of disease. 1822(8):1308-1315