ZFIN ID: ZDB-LAB-150413-1
The Wang Laboratory
PI/Director: Wang, Han
Co-PI / Senior
Liu, Chao
Sun, Yi
Zhong, Yingbin
Contact Person: Hu, Yingying
Email: huyingying860817@163.com
Address: Center for Circadian Clocks Soochow University 199 Renai Road Suzhou, Jiangsu, 215123 China
Country: China
Phone: 86 512 65881257
Fax: 86 512 65882115
Line Designation: sus

Show all 15 genomic features

Most organisms display daily changes at molecular, cellular, physiological, and behavioral levels, which are known as circadian rhythms. The circadian clock controls fundamental life processes such as the human sleep-wake cycle. Many human sleep disorders and dysrhythmias are thought to result from circadian defects. A full molecular genetic understanding of circadian rhythmicity is critical for diagnosis, prevention and treatment of human dysrhythmias. We study molecular genetic mechanisms underlying zebrafish circadian rhythmicity. Using TALEN and CRISPR-Cas9 techniques, we have generated a number of mutants for zebrafish circadian clock genes. The roles of these circadian clock genes in the circadian system and life processes are investigated.

We also used zebrafish to study a group of human diseases called porphyria, derived from defective enzymes in heme biosynthesis. We have established several zebrafish models for human porphyria. We are interested in studying novel aspects of porphyria pathogenesis.

Liu, Taole Post-Doc Wang, Mingyong Post-Doc Deng, Bo Graduate Student
He, Wei Graduate Student Huang, Guodong Graduate Student Liu, Huazhen Graduate Student
Niu, Pengfei Graduate Student Niu, Zhijie Graduate Student Wang, Jingjing Graduate Student
Wang, Tuoyi Graduate Student Xu, Shuhao Graduate Student Yang, Fan Graduate Student
Ye, Qiang Graduate Student Yuan, Shiyu Graduate Student Zhang, Fanmiao Graduate Student
Zhang, Jiguang Graduate Student Zhang, Shuqing Graduate Student Zhang, Wei Graduate Student
Hu, Jia Technical Staff Zhong, Zhaomin Technical Staff Hu, Yingying Administrative Staff
Huang, Jian Ji, Cheng

Huang, Y., Jiang, B., Xia, Y., Wang, J., Ji, C., Tong, J., Chen, T., Jiang, Y. (2020) Downregulation of miR-133a contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish. Chemosphere. 251:126610
Yang, F., Qi, J. (2020) miR-430a regulates the development of left-right asymmetry by targeting sqt in the teleost. Gene. 745:144628
Ren, F., Huang, Y., Tao, Y., Ji, C., Aniagu, S., Jiang, Y., Chen, T. (2020) Resveratrol protects against PM2.5-induced heart defects in zebrafish embryos as an antioxidant rather than as an AHR antagonist. Toxicology and applied pharmacology. 398:115029
Tian, J., Hu, J., He, W., Zhou, L., Huang, Y. (2020) Parental exposure to cadmium chloride causes developmental toxicity and thyroid endocrine disruption in zebrafish offspring. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 234:108782
Hu, J., Chen, L., Yin, J., Yin, H., Huang, Y., Tian, J. (2020) Hyperactivity, Memory Defects, and Craniofacial Abnormalities in Zebrafish fmr1 Mutant Larvae. Behavior Genetics. 50(3):152-160
Chen, Z., Song, Z., Yang, J., Huang, J., Jiang, H. (2019) Sp7/osterix positively regulates dlx2b and bglap to affect tooth development and bone mineralization in zebrafish larvae. Journal of biosciences. 44(6):
Jin, H., Ji, C., Ren, F., Aniagu, S., Tong, J., Jiang, Y., Chen, T. (2019) AHR-mediated oxidative stress contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish embryos. Journal of hazardous materials. 385:121521
Huang, W., Liu, Z., Yang, F., Zhou, H., Yong, X., Yang, X., Zhou, Y., Xue, L., Zhang, Y., Liu, D., Meng, W., Zhang, W., Zhang, X., Shen, X., Sun, Q., Li, L., Ma, C., Wei, Y., Billadeau, D.D., Mo, X., Jia, D. (2019) Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH. Proceedings of the National Academy of Sciences of the United States of America. 116(45):22598-22608
Jiang, Y., Li, J., Ren, F., Ji, C., Aniagu, S., Chen, T. (2019) PM2.5-induced extensive DNA methylation changes in the heart of zebrafish embryos and the protective effect of folic acid. Environmental pollution (Barking, Essex : 1987). 255:113331
Hu, J., Tian, J., Zhang, F., Wang, H., Yin, J. (2019) Pxr- and Nrf2- mediated induction of ABC transporters by heavy metal ions in zebrafish embryos. Environmental pollution (Barking, Essex : 1987). 255:113329
Fei, F., Wang, L., Sun, S., Lv, K., Yao, Y., Wang, J., Yu, M., Wang, X. (2019) Transgenic Strategies to Generate Heterogeneous Hepatic Cancer Models in Zebrafish. Journal of molecular cell biology. 11(11):1021-1023
Shang, G., Peng, X., Ji, C., Zhai, G., Ruan, Y., Lou, Q., Jin, X., He, J., Wang, H., Yin, Z. (2019) Star and LH are required for normal ovarian steroidogenesis and oocyte maturation in zebrafish. Biology of reproduction. 101(4):760-770
Zhou, J., Zhao, H., Zhang, L., Liu, C., Feng, S., Ma, J., Li, Q., Ke, H., Wang, X., Liu, L., Liu, C., Su, X., Liu, Y., Yang, S. (2019) Integrated analysis of RNA-seq and microRNA-seq depicts miRNA-mRNA networks involved in stripe patterns of Botia superciliaris skin. Functional & integrative genomics. 19(5):827-838
Tian, J., Hu, J., Liu, G., Yin, H., Chen, M., Miao, P., Bai, P., Yin, J. (2019) Corrigendum to "Altered gene expression of ABC transporters, nuclear receptors and oxidative stress signaling in zebrafish embryos exposed to CdTe quantum dots"[Environ. Pollut. 244 (2019) 588-599]. Environmental pollution (Barking, Essex : 1987). 245:1136
Zheng, Y., Liu, C., Li, Y., Jiang, H., Yang, P., Tang, J., Xu, Y., Wang, H., He, Y. (2018) Loss-of-function mutations with circadian rhythm regulator Per1/Per2 lead to premature ovarian insufficiency. Biology of reproduction. 100(4):1066-1072
Tian, J., Hu, J., Liu, G., Yin, H., Chen, M., Miao, P., Bai, P., Yin, J. (2018) Altered Gene expression of ABC transporters, nuclear receptors and oxidative stress signaling in zebrafish embryos exposed to CdTe quantum dots. Environmental pollution (Barking, Essex : 1987). 244:588-599
Wang, T., Liu, Y., Liu, H., Li, C., Wang, Y. (2018) Auriculasin from Flemingia philippinensis roots shows good therapeutic indexes on hyperactive behavior in zebrafish. Biochemical and Biophysical Research Communications. 503(3):1254-1259
Jia, R., Song, P., Wang, J., Mai, H., Li, S., Cheng, Y., Wu, S. (2018) Self-Assembled Fluorescent Nanoprobe Based on Forster Resonance Energy Transfer for Carbon Monoxide in Living Cells and Animals via Ligand Exchange. Analytical chemistry. 90(12):7117-7121
He, H., Wang, C., Tang, Q., Yang, F., Xu, Y. (2018) Possible mechanisms of prednisolone-induced osteoporosis in zebrafish larva. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 101:981-987
Huang, D.F., Wang, M.Y., Yin, W., Ma, Y.Q., Wang, H., Xue, T., Ren, D.L., Hu, B. (2018) Zebrafish Lacking Circadian Gene per2 Exhibit Visual Function Deficiency.. Frontiers in behavioral neuroscience. 12:53
He, H., Wang, C., Tang, Q., Yang, F., Xu, Y. (2018) Elucidation of possible molecular mechanisms underlying the estrogen-induced disruption of cartilage development in zebrafish larvae. Toxicology letters. 289:22-27
Zhong, Y., Ye, Q., Chen, C., Wang, M., Wang, H. (2018) Ezh2 promotes clock function and hematopoiesis independent of histone methyltransferase activity in zebrafish. Nucleic acids research. 46(7):3382-3399
Liu, C., Kim, Y.S., Kim, J., Pattison, J., Kamaid, A., Miller, Y.I. (2017) Modeling hypercholesterolemia and vascular lipid accumulation in LDL receptor mutant zebrafish. Journal of Lipid Research. 59(2):391-399
Nie, K., Wang, K., Huang, D.F., Huang, Y.B., Yin, W., Ren, D.L., Wang, H., Hu, B. (2017) Effects of circadian clock protein Per1b on zebrafish visual functions. Chronobiology International. 35(2):160-168
Han, J., Ji, C., Guo, Y., Yan, R., Hong, T., Dou, Y., An, Y., Tao, S., Qin, F., Nie, J., Ji, C., Wang, H., Tong, J., Xiao, W., Zhang, J. (2017) Mechanisms underlying melatonin-mediated prevention of fenvalerate-induced behavioral and oxidative toxicity in zebrafish. Journal of toxicology and environmental health. Part A. 80(23-24):1331-1341
Yue, C., Ji, C., Zhang, H., Zhang, L.W., Tong, J., Jiang, Y., Chen, T. (2017) Protective effects of folic acid on PM2.5-induced cardiac developmental toxicity in zebrafish embryos by targeting AhR and Wnt/β-catenin signal pathways. Environmental toxicology. 32(10):2316-2322
Yao, Y., Sun, S., Fei, F., Wang, J., Wang, Y., Zhang, R., Wu, J., Liu, L., Liu, X., Cui, Z., Li, Q., Yu, M., Dang, Y., Wang, X. (2017) Screening in larval zebrafish reveals tissue-specific distributions of fifteen fluorescent compounds. Disease models & mechanisms. 10(9):1155-1164
Ren, D.L., Ji, C., Wang, X.B., Wang, H., Hu, B. (2017) Endogenous melatonin promotes rhythmic recruitment of neutrophils toward an injury in zebrafish. Scientific Reports. 7:4696
Xiao, B., Cui, L.Q., Ding, C., Wang, H. (2017) Effects of Lithium and 2,4-Dichlorophenol on Zebrafish: Circadian Rhythm Disorder and Molecular Effects. Zebrafish. 14(3):209-215
Tian, J., Hu, J., Chen, M., Yin, H., Miao, P., Bai, P., Yin, J. (2017) The use of mrp1-deficient (Danio rerio) zebrafish embryos to investigate the role of Mrp1 in the toxicity of cadmium chloride and benzo[a]pyrene. Aquatic toxicology (Amsterdam, Netherlands). 186:123-133
Hua, Y., Wang, C., Huang, J., Wang, K. (2017) A simple and efficient method for CRISPR/Cas9-induced mutant screening. Journal of genetics and genomics = Yi chuan xue bao. 44(4):207-213
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Liu, C., Gaudet, D., Miller, Y.I. (2017) Deficient Cholesterol Esterification in Plasma of apoc2 Knockout Zebrafish and Familial Chylomicronemia Patients. PLoS One. 12:e0169939
Zhong, Y., Duan, C. (2017) Lamprey IGF-Binding Protein-3 Has IGF-Dependent and -Independent Actions. Frontiers in endocrinology. 7:174
Yang, J., Pei, H., Luo, H., Fu, A., Yang, H., Hu, J., Zhao, C., Chai, L., Chen, X., Shao, X., Wang, C., Wu, W., Wan, L., Ye, H., Qiu, Q., Peng, A., Wei, Y., Yang, L., Chen, L. (2017) Non-toxic dose of liposomal honokiol suppresses metastasis of hepatocellular carcinoma through destabilizing EGFR and inhibiting the downstream pathways. Oncotarget. 8(1):915-932
Wang, Y., Liu, W., Yang, J., Wang, F., Yizhen, S., Zhong, Z.M., Wang, H., Hu, L.F., Liu, C.F. (2017) Parkinson's disease-like motor and non-motor symptoms in rotenone-treated zebrafish. Neurotoxicology. 58:103-109
Xiao, B., Chen, T.M., Zhong, Y. (2016) Possible molecular mechanism underlying cadmium-induced circadian rhythms disruption in zebrafish. Biochemical and Biophysical Research Communications. 481(3-4):201-205
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Huang, G., Zhang, F., Ye, Q., Wang, H. (2016) The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erbα and indirectly via Cebpb/(C/ebpβ) in zebrafish. Autophagy. 12(8):1292-309
Bo, L., Liu, Z., Zhong, Y., Huang, J., Chen, B., Wang, H., Xu, Y. (2016) Iron deficiency anemia's affect on bone formation in zebrafish mutant. Biochemical and Biophysical Research Communications. 475(3):271-6
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Dana, H., Mohar, B., Sun, Y., Narayan, S., Gordus, A., Hasseman, J.P., Tsegaye, G., Holt, G.T., Hu, A., Walpita, D., Patel, R., Macklin, J.J., Bargmann, C.I., Ahrens, M.B., Schreiter, E.R., Jayaraman, V., Looger, L.L., Svoboda, K., Kim, D.S. (2016) Sensitive red protein calcium indicators for imaging neural activity. eLIFE. 5
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