ZFIN ID: ZDB-LAB-120509-1
Lowe Lab
PI/Director: Lowe, Martin
Contact Person: Lowe, Martin
Email: martin.lowe@manchester.ac.uk
URL: http://www.ls.manchester.ac.uk/research/researchgroups/cellorganisationanddynamics/people/?alias=lowem
Address: Faculty of Life Sciences University of Manchester Michael Smith Building Oxford Road Manchester M13 9PT UK
Country: United Kingdom
Phone: 0044 161 275 5387
Fax: 0044 161 275 5082
Line Designation: umc

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The Lowe Lab studies membrane traffic in the secretory and endocytic pathways. A major interest is the structure and function of the Golgi apparatus. We also study the lipid phosphatase OCRL1, which is mutated in Lowe syndrome and Dent-2 disease, and which plays an important role in endocytic trafficking. We use a combination of mammalian cell culture and zebrafish as experimental systems to carry out this work.

Sato, Keisuke Post-Doc Mehta, Zenobia Graduate Student Oltrabella, Francesca Graduate Student
Pietka, Grzegorz Graduate Student Yan, Guahua Technical Staff

De Leo, E., Elmonem, M.A., Berlingerio, S.P., Berquez, M., Festa, B.P., Raso, R., Bellomo, F., Starborg, T., Janssen, M.J., Abbaszadeh, Z., Cairoli, S., Goffredo, B.M., Masereeuw, R., Devuyst, O., Lowe, M., Levtchenko, E., Luciani, A., Emma, F., Rega, L.R. (2020) Cell-Based Phenotypic Drug Screening Identifies Luteolin as Candidate Therapeutic for Nephropathic Cystinosis. Journal of the American Society of Nephrology : JASN. 31(7):1522-1537
Preston, R., Naylor, R.W., Stewart, G., Bierzynska, A., Saleem, M.A., Lowe, M., Lennon, R. (2019) A role for OCRL in glomerular function and disease. Pediatric nephrology (Berlin, Germany). 35(4):641-648
Vaz, F.M., McDermott, J.H., Alders, M., Wortmann, S.B., Kölker, S., Pras-Raves, M.L., Vervaart, M.A.T., van Lenthe, H., Luyf, A.C.M., Elfrink, H.L., Metcalfe, K., Cuvertino, S., Clayton, P.E., Yarwood, R., Lowe, M.P., Lovell, S., Rogers, R.C., Deciphering Developmental Disorders Study, van Kampen, A.H.C., Ruiter, J.P.N., Wanders, R.J.A., Ferdinandusse, S., van Weeghel, M., Engelen, M., Banka, S. (2019) Mutations in PCYT2 disrupt etherlipid biosynthesis and cause a complex hereditary spastic paraplegia. Brain : a journal of neurology. 142(11):3382-3397
Mondin, V.E., Ben El Kadhi, K., Cauvin, C., Jackson-Crawford, A., Bélanger, E., Decelle, B., Salomon, R., Lowe, M., Echard, A., Carréno, S. (2019) PTEN reduces endosomal PtdIns(4,5)P2 in a phosphatase-independent manner via a PLC pathway. The Journal of cell biology. 218(7):2198-2214
Bruning, J.M., Wang, Y., Oltrabella, F., Tian, B., Kholodar, S.A., Liu, H., Bhattacharya, P., Guo, S., Holton, J.M., Fletterick, R.J., Jacobson, M.P., England, P.M. (2019) Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite. Cell chemical biology. 26(5):674-685.e6
Elmonem, M.A., Berlingerio, S.P., van den Heuvel, L.P., de Witte, P.A., Lowe, M., Levtchenko, E.N. (2018) Genetic Renal Diseases: The Emerging Role of Zebrafish Models. Cells. 7(9)
Oltrabella, F., Melgoza, A., Nguyen, B., Guo, S. (2017) Role of the endocannabinoid system in vertebrates: Emphasis on the zebrafish model. Development, growth & differentiation. 59(4):194-210
Elmonem, M.A., Khalil, R., Khodaparast, L., Khodaparast, L., Arcolino, F.O., Morgan, J., Pastore, A., Tylzanowski, P., Ny, A., Lowe, M., de Witte, P.A., Baelde, H.J., van den Heuvel, L.P., Levtchenko, E. (2017) Cystinosis (ctns) zebrafish mutant shows pronephric glomerular and tubular dysfunction. Scientific Reports. 7:42583
De Leo, M.G., Staiano, L., Vicinanza, M., Luciani, A., Carissimo, A., Mutarelli, M., Di Campli, A., Polishchuk, E., Di Tullio, G., Morra, V., Levtchenko, E., Oltrabella, F., Starborg, T., Santoro, M., di Bernardo, D., Devuyst, O., Lowe, M., Medina, D.L., Ballabio, A., De Matteis, M.A. (2016) Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL. Nature cell biology. 18:839-50
Oltrabella, F., Pietka, G., Ramirez, I.B., Mironov, A., Starborg, T., Drummond, I.A., Hinchliffe, K.A., Lowe, M. (2015) The Lowe Syndrome Protein OCRL1 Is Required for Endocytosis in the Zebrafish Pronephric Tubule. PLoS Genetics. 11:e1005058
Mehta, Z.B., Pietka, G., and Lowe, M. (2014) The Cellular and Physiological Functions of the Lowe Syndrome Protein OCRL1. Traffic (Copenhagen, Denmark). 15(5):471-487
Jones, D.R., Ramirez, I.B., Lowe, M., and Divecha, N. (2013) Measurement of phosphoinositides in the zebrafish Danio rerio. Nature Protocols. 8(6):1058-1072
Coon, B.G., Hernandez, V., Madhivanan, K., Mukherjee, D., Hanna, C.B., Ramirez, I.B., Lowe, M., Beales, P.L., and Aguilar, R.C. (2012) The Lowe Syndrome Protein OCRL1 is Involved in Primary Cilia Assembly. Human molecular genetics. 21(8):1835-1847
Ramirez, I.B., Pietka, G., Jones, D.R., Divecha, N., Aliam, A., Baraban, S.C., Hurlstone, A.F., and Lowe, M. (2012) Impaired Neural Development in a Zebrafish Model for Lowe Syndrome. Human molecular genetics. 21(8):1744-1759